Previous News and Highlights

2017

  • On the occasion of the AEGIS Mid Term Meeting, Nobel Laureate Robert Huber gave a lecture at Institute of Structural Biology on the history of Structural Biology research. He then discussed with the doctoral students of the AEGIS program the newest results of their research projects. A dinner with scientific talks finally formed the successful conclusion.
    press release
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  • Scientists around Sattler and Popowicz at HMGU found together with colleagues from the Technical University of Munich and the Ruhr University Bochum anew therapeutic strategy against trypanosomiases like Chagas and African sleeping sickness. The researchers could first determine the parasite's Achilles heel by using modern structural biology techniques and then develop an inhibitor with a perfect fit.
    press release
    Science article

2016

  • 1st Helmholtz Training Course was held, on the topic "Diffraction Data Collection Using Synchrotron Radiation"
    Nov 7-11, 2016, at Helmholtz Centre for Infection Research, Braunschweig
    Further details, please have a look here
  • Niessing lab publishes new enzyme inhibitors with potential uses against cancer and obesity
    Further details, please have a look here
  • Funding for even two MSC Innovative Training Networks have been  succesfully attracted by Institute of Structural Biology
  • Ekaterina Ratkova was awarded an Alexander von Humboldt-Research Fellowship. She will work on Advanced ligand docking in solution and join the group of Chemoinformatics (Igor Tetko)
  • The group of Michael Sattler could demonstrate that Silibinin, extracted from milk thistle seeds, may allow a novel, non-invasive treatment strategy for Cushing Disease.

2015

  • Funding for even two MSC Innovative Training Networks have been  succesfully attracted by Institute of Structural Biology
  • Ekaterina Ratkova was awarded an Alexander von Humboldt-Research Fellowship. She will work on Advanced ligand docking in solution and join the group of Chemoinformatics (Igor Tetko)
  • The group of Michael Sattler could demonstrate that Silibinin, extracted from milk thistle seeds, may allow a novel, non-invasive treatment strategy for Cushing Disease.

 

2014

  • Scientists around Dr. Janosch Hennig, Dr. Grzegorz Popowicz and Professor Dr. Michael Sattler from HMGU and TUM together with the group of Dr. Fátima Gebauer at the Centre for Genomic Regulation (Barcelona, Spain) have now unraveled a new paradigm for gene regulation. The scientists studied a specific complex formed between regulatory proteins with mRNA in the fruit fly model. This protein complex is essential to ensure that the expression of genes located on the two female (XX) X-chromosomes equals that of genes located on the single male (XY) X-chromosome. The results are published in the renowned scientific journal Nature. [Press Release]

  • Scientists from the Institute for Structural Biology at the Helmholtz Zentrum München, the LMU and the TU München have moved an important step closer to understanding molecular mechanisms of autoimmune diseases. They solved the three-dimensional structure of the Roquin protein when bound to messenger ribonucleic acid (mRNA) molecules. The results revealed that there is a much wider range of functionally important Roquin binding partners than previously assumed. The novel findings are published in the journal Nature Structural & Molecular Biology. [Press Release]

  • Dr. Ana Messias, Dr. Arie Geerlof and Dr. Arcangela Iuso from the Helmholtz Zentrum München have received a research grant from the Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders Association. The scientists plan to use the $45,000 research funding to analyze the 3D structure and function of the C19orf12 gene, a novel and one of the most common genetic factors in NBIA. [Press Release]

     

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  • Learning from sharks - optimization of human antibodies: Scientists from the Institute for Structural Biology at Helmholtz Zentrum München found together with colleagues of TU München and of St. Jude Children’s Research Hospital in Memphis (Tennessee, USA) a new approach for stabilizing human antibodies by adapting the chemical properties of the immunoglobulins to those of sharks. [Press Release]

  • New insights into the tau protein deposits in Alzheimer's disease: Madl Group unveils the molecular recognition of proteins responsible for Alzheimer’s by chaperones[Press Release]

  • Sattler Group discovers a novel protein-protein interaction important for biogenesis of peroxisomes implicated in the Zellweger Syndrome disease.

  • New BNMRZ Building & 1.2 GHz Spectrometer Approved!
    April 29, 2013: The German Federal Science Council (Wissenschaftsrat) has approved the 30 mio. € application of the BNMRZ for a new dedicated building, including a 1.2 GHz NMR spectrometer. The building is scheduled to be finished in 2016, delivery of the new NMR spectrometer is planned for 2018. [Press Release]

 

2013

  • The Science Council has decided the new building for the new Bavarian NMR Center on the campus of the Technical University of Munich (TUM) in Garching. The total cost of 33 million euros include - besides the building with initial setup - a 1.2 GHz spectrometer. This will be the only universitary equipment of that class on national level. The nuclear magnetic resonance spectroscopy (NMR) plays a prominent role in the chemical and biochemical analysis and is particularly used to study the spatial structure and dynamics of proteins. [Press Release]

  • In Fall 2013, the X-ray Crystallography Platform moved to its newly established lab in building 57. This platform offers scientists at the Helmholtz Zentrum München access to the most common technology for high-resolution structures of biomolecules. The crystallography platform is also suitable for the structure-based development of small-molecule inhibitors, thereby complementing other platforms of the Institute of Structural Biology as well as the Assay Development and Screening Platform. The crystallography platform is managed by our staff scientist Dr. Robert Janowski.

  • A new fragment-based drug discovery (FBDD) screening facility has commenced operation in May 2013. Integrated into the Institute of Structural Biology (STB), the facility uses specialized high-throughput NMR equipment to search for small molecules, called fragments that have biological and potentially therapeutic activity. [Press Release]

2012

  • Dr. Tobias Madl was accepted into Emmy-Noether-Programme of the Deutschen Forschungsgemeinschaft (DFG). His research project in the field of systemic analysis of multifactorial diseases is concerned with molecular mechanisms that affect cell aging and the development of diseases. [Press Release]

  • First diagnostic markers for pre-diabetes discovered. Scientists at the Helmholtz Zentrum München found three biomarkers which can be used for detection of type 2 diabetes in early stages and possibly used for prevention.[ Press Release]

2011

  • New mechanism in the regulation of human genes. Scientists at the Helmholtz Zentrum München and the Technische Universität München have now discovered how the U2AF protein enables this process. [Press Release]

  • Intracellular  logistics – Scientists of Helmholtz Zentrum München and the Ludwig-Maximilians Universität München dissect transport mechanism. [ Press Release][ Weekly Editor's pick]

2010

  • X-ray structure reveals a potential role of myosin tails in membrane anchoring 
    Valuable Insights – Scientists of Helmholtz Zentrum München and the Technische Universität München Elucidate the Structural Details of a Key Protein for Cellular Signal Transduction [ Press Release]
  • Structure determination of biomolecules in their natural environment by NMR spectroscopy- an efficient basis for drug development [Press Release]

2009

  • X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface [Scientific Highlight including Press Release "Trembling hands and a molecular handshake - a novel protein structure involved in hereditary neurodegeneration" [ Press Release]

2008

  • Molecular insights into directional transport of mRNA and endoplasmic reticulum [Scientific Highlight]

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