Our Structures

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.

Pubmed

PDB-ID: 4BA8

 

Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.

Pubmed

PDB-ID: 2M09, 2M0G

 

Structural and functional analysis of the DEAF-1 and BS69 MYND domains.

Pubmed

PDB-ID:4A24

 

Structure of the EB1-like domain of microtubule-associated protein Bim1p

Pubmed

PDB-ID: 4E61

 

Structure and Functional Analysis of Ipse Alpha-1, an Il-4-Inducing Factor Secreted from Schistosoma Mansoni Eggs, Reveals an Ige-Binding Crystallin Fold

PDB-ID: 4AKA

 

Solution structure and molecular interactions of lamin B receptor Tudor domain.

Pubmed

PDB-ID: 2L8D

 

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.

Pubmed

SMN Tudor PDB-IDs: 4A4E, 4A4G

SPF30 Tudor PDB-IDs: 4A4F, 4A4H

 

The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization

Pubmed

PDB-ID: 2Y95

 

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.

Pubmed

PDB-ID: 2YH0 (Closed), 2YH1 (Open)

 

Structure and VP16 binding of the Mediator Med25 activator interaction domain.

Pubmed

PDB-ID: 2XNF

 

 NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Pubmed

PDB-ID: 2L1L

 

Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin

Pubmed

PDB-ID: 1XXO

 

Of bits and bugs - on the use of bioinformatics and a bacterial crystal structure to solve a eukaryotic repeat-protein structure

http://www.ncbi.nlm.nih.gov/pubmed/20976240  PubMed

PDB-ID 3N8B  /  PDB-ID 3NM7

 

Structure of an atypical Tudor domain in the Drosophila Polycomblike protein

PubMed

PDB-ID: 2XKO

 

Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 homodimerization domain is required for regulation of alternative splicing by Sam68.

Pubmed

PDB-ID: 2XA6

 

Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX

Pubmed

PDB-ID: 2XC7

The structure of the Myo4p globular tail

PubMed | PDF

PDB-ID: 3MMI

 

The X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-binding surface

 Pubmed

PDB-ID: 3K44

 

Structure and ligand binding of the extended Tudor domain of D. Melanogaster Tudor-SN

 Pubmed

PDB-ID: 2WAC

 

Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19

Pubmed

PDB-ID: 2W84/2W85

Dimerization and protein binding specificity of the U2AF homology motif (UHM) of the splicing factor Puf60

Pubmed

PDB-ID: 3DXB

 

Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.

Pubmed

PDB-ID: 2JXC

 

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45

Pubmed

PDB-ID: 2PE8/2PEH

Structure and CTD binding of the Set2 SRI domain that couples histone H3 K36 methylation to transcription

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition

 Pubmed

PDB-ID: 2B9Z

 

Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl

Pubmed

PDB-ID: 1ZZP

Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily.

Pubmed

PDB-ID: 1W4M

 

X-ray structure of the unusual RNA-binding protein She2p at 1.95 Å resolution.

Pubmed

PDB-ID: 1XLY

 

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain.

      PDB-IDs: 1T2R, 1T2S

     Pubmed

 

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain.

      PDB-ID: 1VYN

      Pubmed

 

Structural Basis for the Molecular Recognition between Human Splicing Factors U2AF(65) and SF1/mBBP.

      PDB-IDs: 1O0P, 1OPI

     Pubmed

 

Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain.

      PDB-ID: 1N5Z, 1JQQ

      Pubmed

 

Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression.

      PDB-ID: 1KKS

      Pubmed

 

Structural basis for recognition of the intron branch site RNA by splicing factor 1.

      PDB-ID: 1K1G

     Pubmed

 

The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

      PDB-ID: 1H5P

     Pubmed

 

SMN tudor domain structure and its interaction with the Sm proteins.

      PDB-ID: 1G5V

     Pubmed

 

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.

      PDB-ID: 1D8B

     Pubmed

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