Publications

Chakraborty, A. ; Ko, C. ; Henning, C. ; Lucko, A. ; Harris, J.M. ; Chen, F. ; Zhuang, X. ; Wettengel, J.M. ; Roessler, S. ; Protzer, U. ; McKeating, J.A.

Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.

Cell. Microbiol., accepted (2020)

Wettengel, J.M. ; Burwitz, B.J.

Innovative HBV animal models based on the entry receptor NTCP.

Viruses 12:828 (2020)

Tian, X. ; Li, R. ; Jiang, Y. ; Zhao, F. ; Yu, Z. ; Wang, Y. ; Dong, Z. ; Liu, P. ; Li, X.

Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake.

J. Funct. Food. 72:104045 (2020)

Muenchhoff, M. ; Mairhofer, H. ; Nitschko, H. ; Grzimek-Koschewa, N. ; Hoffmann, D. ; Berger, A. ; Rabenau, H. ; Widera, M. ; Ackermann, N. ; Konrad, R. ; Zange, S. ; Graf, A. ; Krebs, S. ; Blum, H. ; Sing, A. ; Liebl, B. ; Wölfel, R. ; Ciesek, S. ; Drosten, C. ; Protzer, U. ; Boehm, S. ; Keppler, O.T.

Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020.

Euro Surveill. 25, 2-6 (2020)

Khan Mirzaei, M. ; Xue, J. ; Costa, R. ; Ru, J. ; Schulz, S. ; Taranu, Z.E. ; Deng, L.

Challenges of studying the human virome – relevant emerging technologies.

Trends Microbiol., accepted (2020)

Beyer, M. ; Abdullah, Z. ; Chemnitz, J.M. ; Maisel, D. ; Sander, J. ; Lehmann, C. ; Thabet, Y. ; Shinde, P.V. ; Schmidleithner, L. ; Köhne, M. ; Trebicka, J. ; Schierwagen, R. ; Hofmann, A. ; Popov, A. ; Lang, K.S. ; Oxenius, A. ; Buch, T. ; Kurts, C. ; Heikenwälder, M. ; Fätkenheuer, G. ; Lang, P.A. ; Hartmann, P. ; Knolle, P.A. ; Schultze, J.L.

Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infection (Nature Immunology, (2016), 17, 5, (593-603), 10.1038/ni.3399).

Nat. Immunol., accepted (2020)

Jung, S. ; Altstetter, S. ; Protzer, U.

Innate immune recognition and modulation in hepatitis D virus infection.

World J. Gastroenterol. 26, 2781-2791 (2020)

Körber, N. ; Behrends, U. ; Protzer, U. ; Bauer, T.

Evaluation of T-activated proteins as recall antigens to monitor Epstein-Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting.

J. Transl. Med. 18:242 (2020)

Schreiber, S. ; Honz, M. ; Schiemann, M. ; Sette, A. ; Zielinski, C. ; Protzer, U. ; Wisskirchen, K.

Characterization of MHC class II-restricted t-cell receptors for t-cell therapy of HBV infection.

Mol. Ther. 28, 520-520 (2020)

Lucifora, J. ; Michelet, M. ; Rivoire, M. ; Protzer, U. ; Durantel, D. ; Zoulim, F.

Two-dimensional-cultures of primary human hepatocytes allow efficient HBV infection: Old tricks still work!

J. Hepatol. 73, 449-451 (2020)

Wolf, G.K. ; Glueck, T. ; Huebner, J. ; Muenchhoff, M. ; Hoffmann, D. ; French, L.E. ; Keppler, O.T. ; Protzer, U.

Clinical and epidemiological features of a family cluster of symptomatic and asymptomatic severe acute respiratory syndrome Coronavirus 2 infection.

J. Pediatr. Infect. Dis. Soc. 9, 362-365 (2020)

Namineni, S. ; O'Connor, T. ; Faure-Dupuy, S. ; Johansen, P. ; Riedl, T. ; Liu, K. ; Xu, H. ; Singh, I. ; Shinde, P. ; Li, F. ; Pandyra, A. ; Sharma, P. ; Ringelhan, M. ; Muschaweckh, A. ; Borst, K. ; Blank, P. ; Lampl, S. ; Neuhaus, K. ; Durantel, D. ; Farhat, R. ; Weber, A. ; Lenggenhager, D. ; Kündig, T.M. ; Staeheli, P. ; Protzer, U. ; Wohlleber, D. ; Holzmann, B. ; Binder, M. ; Breuhahn, K. ; Assmus, L.M. ; Nattermann, J. ; Abdullah, Z. ; Rolland, M. ; Dejardin, E. ; Lang, P.A. ; Lang, K.S. ; Karin, M. ; Lucifora, J. ; Kalinke, U. ; Knolle, P.A. ; Heikenwälder, M.

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

J. Hepatol. 72, 960-975 (2020)

Baumann, T. ; Dunkel, A. ; Schmid, C. ; Schmitt, S. ; Hiltensperger, M. ; Lohr, K. ; Laketa, V. ; Donakonda, S. ; Ahting, U. ; Lorenz-Depiereux, B. ; Heil, J.E. ; Schredelseker, J. ; Simeoni, L. ; Fecher, C. ; Körber, N. ; Bauer, T. ; Hüser, N. ; Hartmann, D. ; Laschinger, M. ; Eyerich, K. ; Eyerich, S. ; Anton, M. ; Streeter, M. ; Wang, T. ; Schraven, B. ; Spiegel, D. ; Assaad, F. ; Misgeld, T. ; Zischka, H. ; Murray, P.J. ; Heine, A. ; Heikenwälder, M. ; Korn, T. ; Dawid, C. ; Hofmann, T. ; Knolle, P.A. ; Höchst, B.

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.

Nat. Immunol. 21, 555-566 (2020)

Stubbe, M. ; Mai, J. ; Paulus, C. ; Stubbe, H.C. ; Berscheminski, J. ; Karimi, M. ; Hofmann, S. ; Weber, E. ; Hadian, K. ; Hay, R. ; Groitl, P. ; Nevels, M. ; Dobner, T. ; Schreiner, S.

Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers.

mBio 11:00049-20 (2020)

Mirzaei, M.K. ; Khan, M.A.A. ; Ghosh, P. ; Taranu, Z.E. ; Taguer, M. ; Ru, J. ; Chowdhury, R. ; Kabir, M.M. ; Deng, L. ; Mondal, D. ; Maurice, C.F.

Bacteriophages isolated from stunted children can regulate gut bacterial communities in an age-specific manner.

Cell Host Microbe 27, 199-212 (2020)

Chen, W. ; Zhang, K. ; Dong, P. ; Fanning, G. ; Tao, C. ; Zhang, H. ; Guo, S. ; Wang, Z. ; Hong, Y. ; Yang, X. ; Lai, S. ; Ding, H. ; Zhao, H. ; Zeng, C. ; Protzer, U. ; Zhang, D.

Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.

Hepatol. Int., accepted (2020)

Michler, T. ; Kosinska, A. ; Festag, J. ; Bunse, T. ; Su, J. ; Ringelhan, M. ; Imhof, H. ; Grimm, D. ; Steiger, K. ; Mogler, C. ; Heikenwalder, M. ; Michel, M.L. ; Guzman, C.A. ; Milstein, S. ; Sepp-Lorenzino, L. ; Knolle, P. ; Protzer, U.

Knockdown of virus antigen expression increases therapeutic vaccine efficacy in high-titer hepatitis B virus carrier mice.

Gastroenterology 158, 1762-1775 (2020)

Herrmann, A. ; Roesner, M. ; Werner, T. ; Hauck, S.M. ; Koch, A. ; Bauer A. ; Schneider, M. ; Brack-Werner, R.

Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin.

Sci. Rep. 10:1326 (2020)

Müller, C. ; Kremb, S. ; Gonsior, M. ; Brack-Werner, R. ; Voolstra, C.R. ; Schmitt-Kopplin, P.

Advanced identification of global bioactivity hotspots via screening of the metabolic fingerprint of entire ecosystems.

Sci. Rep. 10:1319 (2020)

Hofmann, S. ; Mai, J. ; Masser, S. ; Groitl, P. ; Herrmann, A. ; Sternsdorf, T. ; Brack-Werner, R. ; Schreiner, S.

ATO (Arsenic Trioxide) effects on promyelocytic leukemia nuclear bodies reveals antiviral intervention capacity.

Adv. Sci. 7:1902130 (2020)

Kurmayer, R. ; Entfellner, E. ; Weisse, T. ; Offterdinger, M. ; Rentmeister, A. ; Deng, L.

Chemically labeled toxins or bioactive peptides show a heterogeneous intracellular distribution and low spatial overlap with autofluorescence in bloom-forming cyanobacteria.

Sci. Rep. 10:2781 (2020)

Marschall, M. ; Strojan, H. ; Kiener, R. ; Wangen, C. ; Sonntag, E. ; Müller, R. ; Zeitträger, I. ; Wagner, S. ; Stamminger, T. ; Milbradt, J. ; Behrends, U. ; Körber, N. ; Bauer, T. ; Schrödel, S. ; Thirion, C. ; Wagner, R. ; Hutterer, C.

Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-Herpesviruses provides a signature o virus-specific signalling.

J. Gen. Virol. 101, 284-289 (2020)

Yan, X. ; Atorf, J. ; Ramos, D. ; Thiele, F. ; Weber, S. ; Dalke, C. ; Sun, M. ; Puk, O. ; Michel, D. ; Fuchs, H. ; Klaften, M. ; Przemeck, G.K.H. ; Sabrautzki, S. ; Favor, J. ; Ruberte, J. ; Kremers, J. ; Hrabě de Angelis, M. ; Graw, J. ; German Mouse Clinic Consortium

Mutation in Bmpr1b leads to Ooptic disc coloboma and ventral retinal gliosis in mice.

Invest. Ophthalmol. Vis. Sci. 61:44 (2020)

Tan, A.T. ; Schreiber, S.

Adoptive T-cell therapy for HBV-associated HCC and HBV infection.

Antiviral Res. 176:104748 (2020)

Jung, S. ; Altstetter, S. ; Wilsch, F. ; Shein, M. ; Schütz, A.K. ; Protzer, U.

Extracellular vesicles derived from Hepatitis-D Virus infected cells induce a proinflammatory cytokine response in human peripheral blood mononuclear cells and macrophages.

Matters, accepted (2020)

Liu, X. ; Huang, H. ; Jiang, Y. ; Wang, T. ; Xu, Y. ; Abbaszade, G. ; Schnelle-Kreis, J. ; Zimmermann, R.

Assessment of German population exposure levels to PM10 based on multiple spatial-temporal data.

Environ. Sci. Pollut. Res. 27, 6637-6648 (2020)

Loffredo-Verde, E. ; Bhattacharjee, S. ; Malo, A. ; Festag, J. ; Kosinska, A. ; Ringelhan, M. ; Rim Sarkar, S. ; Steiger, K. ; Heikenwälder, M. ; Protzer, U. ; Prazeres da Costa, C.U.

Dynamic, helminth-induced immune modulation influences the outcome of acute and chronic hepatitis B virus infection.

J. Infect. Dis. 221, 1448-1461 (2020)

Qian, Z. ; Bruhn, T. ; D'Agostino, P.M. ; Herrmann, A. ; Haslbeck, M. ; Antal, N. ; Fiedler, H.P. ; Brack-Werner, R. ; Gulder, T.A.M.

Discovery of the streptoketides by direct cloning and rapid heterologous expression of a cryptic PKS II gene cluster from streptomyces sp. Tü 6314.

J. Org. Chem. 85, 664-673 (2020)

Ma, T. ; Jiang, Y. ; Elbehery, A.H.A. ; Blank, S. ; Kurmayer, R. ; Deng, L.

Resilience of planktonic bacterial community structure in response to short-term weather deterioration during the growing season in an alpine lake.

Hydrobiologia 847, 535-548 (2020)

D'Arienzo, V. ; Magri, A. ; Harris, J.M. ; Wing, P.A.C. ; Ko, C. ; Rubio, C.O. ; Revill, P.A. ; Protzer, U. ; Balfe, P. ; McKeating, J.A.

A PCR assay to quantify patterns of HBV transcription.

J. Gen. Virol., accepted (2019)

Schreiber, S. ; Honz, M. ; Schiemann, M. ; Sette, A. ; Zielinski, C. ; Protzer, U. ; Wisskirchen, K.

Characterization of MHC class II-restricted t-cell receptors for t-cell therapy of HBV infection.

Hum. Gene Ther. 30, A10-A10 (2019)

Gassen, N.C. ; Niemeyer, D. ; Corman, V.M. ; Martinelli, S. ; Gassen, A. ; Hafner, K. ; Papies, J. ; Mösbauer, K. ; Zellner, A. ; Zannas, A.S. ; Herrmann, A. ; Holsboer, F. ; Brack-Werner, R. ; Boshart, M. ; Müller-Myhsok, B. ; Drosten, C. ; Müller, M.A. ; Rein, T.

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection.

Nat. Commun. 10:5770 (2019)

Sib, A. ; Milzarek, T.M. ; Herrmann, A. ; Oubraham, L. ; Müller, J.I. ; Pichlmair, A. ; Brack-Werner, R. ; Gulder, T.A.M.

Chemoenzymatic total synthesis of sorbicatechol structural analogues and evaluation of their antiviral potential.

ChemBioChem, accepted (2019)

Afridi, S.Q. ; Kalali, B. ; Wettengel, J.M. ; Quitt, O. ; Semper, R. ; Gerhard, M. ; Protzer, U. ; Hoffmann, D.

Quantitation of norovirus-specific IgG before and after infection in immunocompromised patients.

Braz. J. Microbio., accepted (2019)

Ko, C. ; Bester, R. ; Zhou, X. ; Xu, Z. ; Blossey, C. ; Sacherl, J. ; Vondran, F.W.R. ; Gao, L. ; Protzer, U.

A new role for capsid assembly modulators to target mature hepatitis B virus capsids and prevent virus infection.

Antimicrob. Agents Chemother. 64, accepted (2019)

Bianco, G. ; Montazeri, H. ; Quagliata, L. ; O'Connor, T. ; Ehmer, U. ; Oellinger, R. ; Matter, M. ; Gerhard, C.M. ; Ng, C.K.Y. ; Piscuoglio, S. ; Heikenwaelder, M. ; Terracciano, L.M.

HOXA13 drives hepatocytes proliferation and liver tumorigenesis in mice.

Cancer Res. 79 (2019)

Hu, J. ; Protzer, U. ; Siddiqui, A.

Revisiting hepatitis B virus: Challenges of curative therapies.

J. Virol. 93:e01032-19 (2019)

O'Connor, T. ; Zhou, X. ; Kosla, J. ; Adili, A. ; Garcia Beccaria, M. ; Kotsiliti, E. ; Pfister, D. ; Johlke, A.-L. ; Sinha, A. ; Sankowski, R. ; Schick, M. ; Lewis, R. ; Dokalis, N. ; Seubert, B. ; Höchst, B. ; Inverso, D. ; Heide, D. ; Zhang, W. ; Weihrich, P. ; Manske, K. ; Wohlleber, D. ; Anton, M. ; Hoellein, A. ; Seleznik, G.M. ; Bremer, J. ; Bleul, S. ; Augustin, H.G. ; Scherer, F. ; Koedel, U. ; Weber, A. ; Protzer, U. ; Förster, R. ; Wirth, T. ; Aguzzi, A. ; Meissner, F. ; Prinz, M. ; Baumann, B. ; Höpken, U.E. ; Knolle, P.A. ; von Baumgarten, L. ; Keller, U. ; Heikenwälder, M.

Cancer Cell 36, 250-267.e9 (2019)

Overacker, R. ; Banerjee, S. ; Neuhaus, G. ; Sephton, S. ; Herrmann, A. ; Strother, J. ; Brack-Werner, R. ; Blakemore, P. ; Loesgen, S.

Biological evaluation of molecules of the azaBINOL class as antiviral agents reveals specific inhibition of HIV-1 RNase H activity.

Abstr. Pap. Am. Chem. Soc. 257 (2019)

Li, K. ; Neumann, K. ; Duhan, V. ; Namineni, S. ; Hansen, A.L. ; Wartewig, T. ; Kurgyis, Z. ; Holm, C.K. ; Heikenwälder, M. ; Lang, K.S. ; Ruland, J.

The uric acid crystal receptor Clec12A potentiates type I interferon responses.

Proc. Natl. Acad. Sci. U.S.A. 116, 18544-18549 (2019)

Džunková, M. ; Low, S.J. ; Daly, J.N. ; Deng, L. ; Rinke, C. ; Hugenholtz, P.

Defining the human gut host-phage network through single-cell viral tagging.

Nat. Microbiol. 4, 2192-2203 (2019)

Kosinska, A. ; Moeed, A. ; Kallin, N. ; Festag, J. ; Su, J. ; Steiger, K. ; Michel, M.L. ; Protzer, U. ; Knolle, P.A.

Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Sci. Rep. 9:10808 (2019)

Koppe, C. ; Reisinger, F. ; Wehr, K. ; Vucur, M. ; Trautwein, C. ; Tacke, F. ; Heikenwalder, M. ; Luedde, T.

An NF-kappaB- and IKK-independent function of NEMO prevents hepatocarcinogenesis by suppressing compensatory liver regeneration.

Cancers 11:999 (2019)

Möhl, B.S. ; Chen, J. ; Longnecker, R.

Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells.

In:. 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa: Elsevier Academic Press Inc, 2019. 313-343 (Adv. Virus Res. ; 104)

Overacker, R.D. ; Banerjee, S. ; Neuhaus, G.F. ; Milicevic Sephton, S. ; Herrmann, A. ; Strother, J.A. ; Brack-Werner, R. ; Blakemore, P.R. ; Loesgen, S.

Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl) quinoline.

Bioorg. Med. Chem. 27, 3595-3604 (2019)

Jiang, Y. ; Huang, H. ; Ma, T. ; Ru, J. ; Blank, S. ; Kurmayer, R. ; Deng, L.

Temperature response of planktonic microbiota in remote alpine lakes.

Front. Microbiol. 10:1714 (2019)

Schreiber, S. ; Honz, M. ; Schiemann, M. ; Zielinski, C. ; Protzer, U. ; Wisskirchen, K.

Characterization of MHC class II-restricted t-cell receptors for t-cell therapy of HBV infection.

Cytotherapy 21, S10-S10 (2019)

Velkov, S. ; Protzer, U. ; Michler, T.

Approximation of the genotype distribution within global chronic hepatitis B virus infections.

J. Hepatol. 70, E711-E711 (2019)

Schreiber, S. ; Honz, M. ; Schiemann, M. ; Zielinski, C. ; Protzer, U. ; Wisskirchen, K.

Characterization of a library of CD4+T cells for T-cell therapy of HBV infection.

J. Hepatol. 70, E456-E456 (2019)

Su, J. ; Kosinska, A. ; Brunner, L. ; Sacherl, J. ; Frank, G. ; Singethan, K. ; Hasreiter, J. ; Thiele, F. ; Collin, N. ; Protzer, U.

Exploring TH1/TH2 adjuvants to improve the efficacy of the therapeutic vaccination against chronic hepatitis B.

J. Hepatol. 70, E485-E486 (2019)

Oberhardt, V. ; Karimzadeh, H. ; Kiraithe, M.M. ; Alizei, E.S. ; Bockmann, J. ; Zur Wiesch, J.S. ; Budeus, B. ; Hoffmann, D. ; Wedemeyer, H. ; Rodriguez-Frias, F. ; Casillas, R. ; Buti, M. ; Smedile, A. ; Alavian, S.M. ; Heinold, A. ; Emmerich, F. ; Panning, M. ; Gostick, E. ; Price, D.A. ; Timm, J. ; Hofmann, M. ; Raziorrouh, B. ; Thimme, R. ; Protzer, U. ; Roggendorf, M. ; Neumann-Haefelin, C.

Viral escape contributes to the failure of hepatitis D virus-specific CD8+T-cells and drives evolution of HDV.

J. Hepatol. 70, E21-E21 (2019)

Wisskirchen, K. ; Kah, J. ; Malo, A. ; Asen, T. ; Volz, T. ; Allweiss, L. ; Wettengel, J.M. ; Lütgehetmann, M. ; Urban, S. ; Bauer, T. ; Dandri, M. ; Protzer, U.

T cell receptor grafting allows virological control of hepatitis B virus infection.

J. Clin. Invest. 130, 2932-2945 (2019)

Tejera, B. ; López, R.E. ; Hidalgo, P. ; Cárdenas, R. ; Ballesteros, G. ; Rivillas, L. ; French, L. ; Amero, C. ; Pastor, N. ; Santiago, Á. ; Groitl, P. ; Dobner, T. ; Gonzalez, R.A.

The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism.

PLoS ONE 14:e0214882 (2019)

Abdelkareem, A.O. ; Khalil, M.I. ; Elaraby, M. ; Abbas, H. ; Elbehery, A.H.A.

VirNet: Deep attention model for viral reads identification.

Proceedings - 2018 13th International Conference on Computer Engineering and Systems, ICCES 2018, 623-626 (2019)

Malehmir, M. ; Pfister, D. ; Gallage, S. ; Szydlowska, M. ; Inverso, D. ; Kotsiliti, E. ; Leone, V. ; Peiseler, M. ; Surewaard, B.G.J. ; Rath, D. ; Ali, A. ; Wolf, M.J. ; Drescher, H. ; Healy, M.E. ; Dauch, D. ; Kroy, D. ; Krenkel, O. ; Kohlhepp, M. ; Engleitner, T. ; Olkus, A. ; Sijmonsma, T. ; Volz, J. ; Deppermann, C. ; Stegner, D. ; Helbling, P. ; Nombela-Arrieta, C. ; Rafiei, A. ; Hinterleitner, M. ; Rall, M. ; Baku, F. ; Borst, O. ; Wilson, C.L. ; Leslie, J. ; O'Connor, T. ; Weston, C.J. ; Adams, D.H. ; Sheriff, L. ; Teijeiro, A. ; Prinz, M. ; Bogeska, R. ; Anstee, N. ; Bongers, M.N. ; Notohamiprodjo, M. ; Geisler, T. ; Withers, D.J. ; Ware, J. ; Mann, D.A. ; Augustin, H.G. ; Vegiopoulos, A. ; Milsom, M.D. ; Rose, A.J. ; Lalor, P.F. ; Llovet, J.M. ; Pinyol, R. ; Tacke, F. ; Rad, R. ; Matter, M. ; Djouder, N. ; Kubes, P. ; Knolle, P.A. ; Unger, K. ; Zender, L. ; Nieswandt, B. ; Gawaz, M. ; Weber, A. ; Heikenwalder, M.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Nat. Med. 25, 641-655 (2019)

Wing, P.A. ; Davenne, T. ; Wettengel, J.M. ; Lai, A.G. ; Zhuang, X. ; Chakraborty, A. ; D'Arienzo, V. ; Kramer, C. ; Ko, C. ; Harris, J.M. ; Schreiner, S. ; Higgs, M. ; Roessler, S. ; Parish, J.L. ; Protzer, U. ; Balfe, P. ; Rehwinkel, J. ; McKeating, J.A.

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.

Life Sci. All. 2:e201900355 (2019)

Bockmann, J.H. ; Stadler, D. ; Xia, Y. ; Ko, C. ; Wettengel, J.M. ; Zur Wiesch, J.S. ; Dandri, M. ; Protzer, U.

Comparative analysis of the antiviral effects mediated by type I and III interferons in hepatitis B virus infected hepatocytes.

J. Infect. Dis. 220, 567-577 (2019)

Festag, M. ; Festag, J. ; Fräßle, S.P. ; Asen, T. ; Sacherl, J. ; Schreiber, S. ; Mück-Häusl, M.A. ; Busch, D.H. ; Wisskirchen, K. ; Protzer, U.

Evaluation of a fully human, hepatitis B virus-specific chimeric antigen receptor in an immunocompetent mouse model.

Mol. Ther. 27, 947-959 (2019)

Pabis, M. ; Corsini, L. ; Vincendeau, M. ; Tripsianes, K. ; Gibson, T.J. ; Brack-Werner, R. ; Sattler, M.

Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.

Nucleic Acids Res. 47, 4859-4871 (2019)

Roblek, M. ; Protsyuk, D. ; Becker, P.F. ; Stefanescu, C. ; Gorzelanny, C. ; Garzon, J.F.G. ; Knopfova, L. ; Heikenwälder, M. ; Luckow, B. ; Schneider, S.W. ; Borsig, L.

CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.

Mol. Cancer Res. 17, 783-793 (2019)

Karimzadeh, H. ; Kiraithe, M.M. ; Oberhardt, V. ; Alizei, E.S. ; Bockmann, J. ; Zur Wiesch, J.S. ; Budeus, B. ; Hoffmann, D. ; Wedemeyer, H. ; Cornberg, M. ; Krawczyk, A. ; Rashidi-Alavijeh, J. ; Rodríguez-Frías, F. ; Casillas, R. ; Buti, M. ; Smedile, A. ; Alavian, S.M. ; Heinold, A. ; Emmerich, F. ; Panning, M. ; Gostick, E. ; Price, D.A. ; Timm, J. ; Hofmann, M. ; Raziorrouh, B. ; Thimme, R. ; Protzer, U. ; Roggendorf, M. ; Neumann-Haefelin, C.

Mutations in hepatitis D virus allow it to escape detection by CD8⁺ T cells and evolve at the population level.

Gastroenterology 156, 1820-1833 (2019)

Nehls, J. ; Businger, R. ; Hoffmann, M. ; Brinkmann, C. ; Fehrenbacher, B. ; Schaller, M. ; Maurer, B. ; Schönfeld, C. ; Kramer, D. ; Hailfinger, S. ; Pöhlmann, S. ; Schindler, M.

Release of immunomodulatory Ebola virus glycoprotein-containingmicrovesicles is suppressed by tetherin in a species-specific manner.

Cell Rep. 26, 1841-1853.e6 (2019)

Yuan, D. ; Luo, S. ; Xu, L. ; Zeng, X. ; Wu, Z.

Regulatory effect of host miR-101b-3p on parasitism of nematode Angiostrongylus cantonensis via superoxide dismutase 3.

Biochim. Biophys. Acta-Gene Regul. Mech. 1862, 557-566 (2019)

Bartenschlager, R. ; Urban, S. ; Protzer, U.

Towards curative therapy of chronic viral hepatitis.

Z. Gastroenterol. 57, 61-73 (2019)

de Sousa-Pereira, P. ; Abrantes, J. ; Bauernfried, S. ; Pierini, V. ; Esteves, P.J. ; Keppler, O.T. ; Pizzato, M. ; Hornung, V. ; Fackler, O.T. ; Baldauf, H.-M.

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.

J. Gen. Virol. 100, 278-288 (2019)

Xia, Y. ; Schlapschy, M. ; Morath, V. ; Röder, N. ; Vogt, E.I. ; Stadler, D. ; Cheng, X. ; Dittmer, U. ; Sutter, K. ; Heikenwälder, M. ; Skerra, A. ; Protzer, U.

PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.

Antiviral Res. 161, 134-143 (2019)

Rosdahl, A. ; Herzog, C. ; Frösner, G. ; Norén, T. ; Rombo, L. ; Askling, H.H.

An extra priming dose of hepatitis A vaccine to adult patients with rheumatoid arthritis and drug induced immunosuppression - A prospective, open-label, multi-center study (vol 21, pg 43, 2018).

Travel Med. Infect. Dis. 27, 115-115 (2019)

Jiang, Y. ; Khan, A. ; Huang, H. ; Tian, Y. ; Yu, X. ; Xu, Q. ; Mou, L. ; Lv, J. ; Zhang, P. ; Liu, P. ; Deng, L. ; Li, X.

Using nano-attapulgite clay compounded hydrophilic urethane foams (AT/HUFs) as biofilm support enhances oil-refinery wastewater treatment in a biofilm membrane bioreactor.

Sci. Total Environ. 646, 606-617 (2019)

van de Klundert, M. ; Ringelhan, M. ; Protzer, U.

Statins suppress hepatitis B virus replication and reduce hepatoma cell viability by interfering with Rho-GTPases.

J. Hepatol. 68, S782-S782 (2018)

Zhang, D. ; Chen, W. ; Zhang, K. ; Dong, P. ; Protzer, U. ; Zeng, C.

Viral integration profiles in the plasma cell-free DNA from patients with HBV infection well represent tumor clone compositions during HCC development.

J. Hepatol. 68, S121-S122 (2018)

Wisskirchen, K. ; Kah, J. ; Malo, A. ; Allweiss, L. ; Metzger, K. ; Volz, T. ; Krackhardt, A. ; Dandri-Petersen, M. ; Protzer, U.

T cells grafted with HBV-specific T-cell receptors of high functional avidity achieve functional cure of HBV infection in humanized mice.

J. Hepatol. 68, S19-S19 (2018)

Michler, T. ; Kosinska, A. ; Bunse, T. ; Heikenwaelder, M. ; Grimm, D. ; Milstein, S. ; Sepp-Lorenzino, L. ; Protzer, U.

Combinatorial RNAi/vaccination therapy for chronic hepatitis B achieves long-term functional cure in preclinical mouse model.

J. Hepatol. 68, S16-S16 (2018)

Hoffmann, M. ; Nehlmeier, I. ; Brinkmann, C. ; Krähling, V. ; Behner, L. ; Moldenhauer, A.S. ; Krüger, N. ; Nehls, J. ; Schindler, M. ; Hoenen, T. ; Maisner, A. ; Becker, S. ; Pöhlmann, S.

Tetherin inhibits nipah Vvrus but not ebola virus replication in fruit bat cells.

J. Virol. 93:01821-18 (2018)

Festag, M. ; Wisskirchen, K. ; Hasreiter, J. ; Schreiber, S. ; Abken, H. ; Protzer, U.

Evaluation of a fully human car for the treatment of hepatitis B virus infection in an immunocompetent mouse model.

Hum. Gene Ther. 29, A4-A4 (2018)

Gehring, A. ; Protzer, U.

Targeting innate and adaptive immune responses to cure chronic HBV infection.

Gastroenterology 156, 325-337 (2018)

Velkov, S. ; Ott, J.J. ; Protzer, U. ; Michler, T.

The global hepatitis B virus genotype distribution approximated from available genotyping data.

Genes 9:495 (2018)

Manske, K. ; Kallin, N. ; König, V. ; Schneider, A. ; Kurz, S. ; Bosch, M. ; Welz, M. ; Cheng, R.L. ; Bengsch, B. ; Steiger, K. ; Protzer, U. ; Thimme, R. ; Knolle, P.A. ; Wohlleber, D.

Outcome of antiviral immunity in the liver is shaped by the level of antigen expressed in infected hepatocytes.

Hepatology, accepted (2018)

Burwitz, B.J. ; Wettengel, J.M. ; Mück-Häusl, M.A. ; Hammond, K.B. ; Ringelhan, M. ; Ko, C. ; Reed, J. ; Norris, R. ; Park, B. ; Moller-Tank, S. ; Esser, K. ; Greenel, J. ; Wu, H. ; Abdulhaqq, S. ; Webb, G. ; Sutton, W.F. ; Klug, A. ; Swanson, T. ; Legasse, A.W. ; Asokan, A. ; Haigwood, N.L. ; Protzer, U. ; Sacha, J.B.

A new HIV/HBV co-infection model: Hepatocytic expression of human sodium taurocholate cotransporting polypeptide (NTCP) Enables Hepatitis B Virus Infection of Macaques.

J. Med. Primatol. 47, 324-324 (2018)

Michler, T. ; Kosinska, A. ; Grimm, D. ; Heikenwalder, M. ; Milstein, S. ; Sepp-Lorenzino, L. ; Knolle, P.A. ; Protzer, U.

Suppression of hepatitis B virus antigens by RNA interference enables therapeutic vaccination to achieve immune control in high-titer virus carriers.

Hepatology 68, 49A-50A (2018)

Kosinska, A. ; Kallin, A. ; Protzer, U. ; Knolle, P.A.

Overcoming liver tolerance to clear persistent HBV infection.

Hepatology 68, 334A-334A (2018)

von Olshausen, G. ; Quasdorff, M. ; Bester, R. ; Arzberger, S. ; Ko, C. ; van de Klundert, M. ; Zhang, K. ; Odenthal, M. ; Ringelhan, M. ; Niessen, C.M. ; Protzer, U.

Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

Oncotarget 9, 33947-33960 (2018)

Ko, C. ; Chakraborty, A. ; Chou, W.M. ; Hasreiter, J. ; Wettengel, J.M. ; Stadler, D. ; Bester, R. ; Asen, T. ; Zhang, K. ; Wisskirchen, K. ; McKeating, J.A. ; Ryu, W.S. ; Protzer, U.

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

J. Hepatol. 69, 1231-1241 (2018)

Schiwon, M. ; Ehrke-Schulz, E. ; Oswald, A. ; Bergmann, T. ; Michler, T. ; Protzer, U. ; Ehrhardt, A.

One-vector system for multiplexed CRISPR/Cas9 against hepatitis B virus cccDNA utilizing high-capacity adenoviral vectors.

Mol. Ther. Nucleic Acids 12, 242-253 (2018)

Faure-Dupuy, S. ; Vegna, S. ; Aillot, L. ; Dimier, L. ; Esser, K. ; Broxtermann, M. ; Bonnin, M. ; Bendriss-Vermare, N. ; Rivoire, M. ; Passot, G. ; Lesurtel, M. ; Mabrut, J.Y. ; Ducerf, C. ; Salvetti, A. ; Protzer, U. ; Zoulim, F. ; Durantel, D. ; Lucifora, J.

Characterization of pattern recognition receptor expression and functionality in liver primary cells and derived cell lines.

J. Innate Immun. 10, 339–348 (2018)

Stadler, D. ; Hess, J. ; Schneider, J. ; Lasitschka, F. ; Ringelhan, M. ; Ko, C. ; Chou, W.M. ; Wettengel, J.M. ; Unger, K. ; Protzer, U.

Identification of ISG20 as the nuclease involved in Interferon-induced decline of HBV cccDNA.

J. Virol. 25, 17-17 (2018)

Schreiber, S. ; Honz, M. ; Schiemann, M. ; Protzer, U. ; Wisskirchen, K.

Generating CD4+T cells for the T-cell therapy of HBV infection.

J. Virol. 25, 47-47 (2018)

Feuerherd, M. ; Körber, N. ; Boesecke, C. ; Mohrmann, K. ; Froeschl, G. ; Ringelhan, M. ; Geisler, F. ; Rockstroh, J. ; Protzer, U. ; Bauer, T.

Altered HBV-specific CD4+T-cell Responses in HBV/HIV-1 Co-versus HBV Mono-infected Patients.

J. Virol. 25, 52-53 (2018)

Chou, W.M. ; Mück-Häusl, M.A. ; Ko, C. ; Wettengel, J.M. ; Protzer, U. ; Stadler, D.

Establishment and characterization of a novel recombinant reporter HBV utilizing the Cre-lox recombination system.

J. Virol. 25, 37-37 (2018)

Brenke, J.K. ; Popowicz, G.M. ; Schorpp, K.K. ; Rothenaigner, I. ; Roesner, M. ; Meininger, I. ; Kalinski, C. ; Ringelstetter, L. ; R'kyek, O. ; Jürjens, G. ; Vincendeau, M. ; Plettenburg, O. ; Sattler, M. ; Krappmann, D. ; Hadian, K.

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.

J. Biol. Chem. 293, 13191-13203 (2018)

Karimzadeh, H. ; Kiraithe, M.M. ; Kosinska, A. ; Glaser, M. ; Fiedler, M. ; Oberhardt, V. ; Alizei, E.S. ; Hofmann, M. ; Mok, J.Y. ; Nguyen, M. ; van Esch, W.J.E. ; Budeus, B. ; Grabowski, J. ; Homs, M. ; Olivero, A. ; Keyvani, H. ; Rodríguez-Frías, F. ; Tabernero, D. ; Buti, M. ; Heinold, A. ; Alavian, S.M. ; Bauer, T. ; Wiesch, J.S.z. ; Raziorrouh, B. ; Hoffmann, D. ; Smedile, A. ; Rizzetto, M. ; Wedemeyer, H. ; Timm, J. ; Antes, I. ; Neumann-Haefelin, C. ; Protzer, U. ; Roggendorf, M.

Amino acid substitutions within HLA-B*27-restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8+ T cells.

J. Virol. 92:13 e01891-17 (2018)

González-Hernández, M. ; Hoffmann, M. ; Brinkmann, C. ; Nehls, J. ; Winkler, M. ; Schindler, M. ; Pöhlmann, S.

A GXXXA motif in the transmembrane domain of the Ebola virus glycoprotein is required for tetherin antagonism.

J. Virol. 92:13 e00403-18 (2018)

Kunze, C. ; Herrmann, A. ; Bauer, A. ; Brack-Werner, R.

Are there strategies against latent infection?

MMW-Fortschr. Med. 160, 35-37 (2018)

Simon, L. ; Karg, S. ; Westermann, A.J. ; Engel, M. ; Elbehery, A.H.A. ; Hense, B.A. ; Heinig, M. ; Deng, L. ; Theis, F.J.

MetaMap: An atlas of metatranscriptomic reads in human disease-related RNA-seq data.

GigaScience 7, 1-8 (2018)

Chen, Y. ; Jiang, Y. ; Huang, H. ; Mou, L. ; Ru, J. ; Zhao, J. ; Xiao, S.

Long-term and high-concentration heavy-metal contamination strongly influences the microbiome and functional genes in Yellow River sediments.

Sci. Total Environ. 637-638, 1400-1412 (2018)

Ning, X. ; Luckenbaugh, L. ; Liu, K. ; Bruss, V. ; Sureau, C. ; Hu, J.J.

Common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions.

J. Virol. 92:e00272-18 (2018)

Reichel, A. ; Stilp, A.C. ; Scherer, M. ; Reuter, N. ; Lukassen, S. ; Kasmapour, B. ; Schreiner, S. ; Cicin-Sain, L. ; Winterpacht, A. ; Stamminger, T.

Chromatin-remodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate early promoter.

J. Virol. 92:e00342-18 (2018)

Ibrahim, B. ; McMahon, D.P. ; Hufsky, F. ; Beer, M. ; Deng, L. ; Mercier, P.L. ; Palmarini, M. ; Thiel, V. ; März, M.

A new era of virus bioinformatics.

Virus Res. 251, 86-90 (2018)

Müncheberg, S. ; Hay, R.T. ; Ip, W.H. ; Meyer, T. ; Weiß, C. ; Brenke, J.K. ; Masser, S. ; Hadian, K. ; Dobner, T. ; Schreiner, S.

E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression.

J. Virol. 92, e00164-18 (2018)

Dembek, C.J. ; Protzer, U. ; Roggendorf, M.

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Curr. Opin. Virol. 30, 58-67 (2018)

Elbehery, A.H.A. ; Feichtmayer, J. ; Singh, D. ; Griebler, C. ; Deng, L.

The human virome protein cluster database (HVPC): A human viral metagenomic database for diversity and function annotation.

Front. Microbiol. 9:1110 (2018)

Weinberger, B. ; Haks, M.C. ; de Paus, R.A. ; Ottenhoff, T.H.M. ; Bauer, T. ; Grubeck-Loebenstein, B.

Impaired immune response to primary but not to booster vaccination against hepatitis B in older adults.

Front. Immunol. 9:1035 (2018)

Blume, K. ; Körber, N. ; Hoffmann, D. ; Wolfarth, B.

Training load, immune status, and clinical outcomes in young athletes: A controlled, prospective, longitudinal study.

Front. Physiol. 9:120 (2018)

Ringelhan, M. ; Pfister, D. ; O'Connor, T. ; Pikarsky, E. ; Heikenwalder, M.

The immunology of hepatocellular carcinoma.

Nat. Immunol. 19, 222-232 (2018)

Suffner, S. ; Gerstenberg, N. ; Patra, M. ; Ruibal, P. ; Orabi, A. ; Schindler, M. ; Bruss, V.

Domains of the hepatitis B virus small surface protein S mediating oligomerization.

J. Virol. 92:e02232-17 (2018)

Hufsky, F. ; Ibrahim, B. ; Beer, M. ; Deng, L. ; Mercier, P.L. ; McMahon, D.P. ; Palmarini, M. ; Thiel, V. ; März, M.

Virologists-Heroes need weapons.

PLoS Pathog. 14:e1006771 (2018)

Lorentzen, A.R. ; Becker, P.F. ; Kosla, J. ; Saini, M. ; Weidele, K. ; Ronchi, P. ; Klein, C. ; Wolf, M.J. ; Geist, F. ; Seubert, B. ; Ringelhan, M. ; Mihic-Probst, D. ; Esser, K. ; Roblek, M. ; Kuehne, F. ; Bianco, G. ; O'Connor, T. ; Müller, Q. ; Schuck, K. ; Lange, S. ; Hartmann, D. ; Spaich, S. ; Groß, O. ; Utikal, J. ; Haferkamp, S. ; Sprick, M.R. ; Damle-Vartak, A. ; Hapfelmeier, A. ; Hüser, N. ; Protzer, U. ; Trumpp, A. ; Saur, D. ; Vartak, N. ; Klein, C.A. ; Polzer, B. ; Borsig, L. ; Heikenwälder, M.

Single cell polarity in liquid phase facilitates tumour metastasis.

Nat. Commun. 9:887 (2018)

Schirmer, D. ; Storz, I. ; Wisskirchen, K. ; Feederle, R. ; Schmidt, O. ; Abken, H. ; Protzer, U. ; Burdach, S. ; Richter, G.

GPR64-specific CAR-trnasgenic T cells selectively kill Ewing sarcoma cells.

Oncol. Res. Treat. 41, 130-130 (2018)

Cirac, A. ; Stützle, S. ; Dieckmeyer, M. ; Adhikary, D. ; Moosmann, A. ; Körber, N. ; Bauer, T. ; Witter, K. ; Delecluse, H.J. ; Behrends, U. ; Mautner, J.

Epstein-Barr virus strain heterogeneity impairs human T-cell immunity.

Cancer Immunol. Immunother. 67, 663-674 (2018)

Esser, K. ; Lucifora, J. ; Wettengel, J.M. ; Singethan, K. ; Glinzer, A. ; Zernecke, A. ; Protzer, U.

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

Antiviral Res. 151, 4-7 (2018)

Freudenberger, N. ; Meyer, T. ; Groitl, P. ; Dobner, T. ; Schreiner, S.

HAdV protein V core protein is targeted by the host SUMOylation machinery to limit essential viral functions.

J. Virol. 92:e01451-17 (2018)

Kunze, C. ; Börner, K. ; Kienle, E. ; Orschmann, T. ; Rusha, E. ; Schneider, M. ; Radivojkov-Blagojevic, M. ; Drukker, M. ; Desbordes, S.C. ; Grimm, D. ; Brack-Werner, R.

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes.

Glia 66, 413-427 (2018)

Kallin, N. ; Bosch, M. ; Manske, K. ; Protzer, U. ; Wohlleber, D. ; Knolle, P.A.

Exhaustion of virus-specific CXCR6+liver-resident memory CD8 T cells during persistent liver infection.

Eur. J. Immunol. 47, 83-83 (2017)

Jung, S. ; Bauer, S.

RIG I senses ribosomal RNA derived degradation products.

Eur. J. Immunol. 47, 79-79 (2017)

Wisskirchen, K. ; Kah, J. ; Malo, A. ; Allweiss, L. ; Volz, T. ; Dandri, M. ; Protzer, U.

Hepatitis B virus (HBV)-specific T cell receptors with high functional avidity redirect T cells to eliminate HBV.

Hum. Gene Ther. 28, A30-A30 (2017)

Storz, I. ; Schirmer, D. ; Wisskirchen, K. ; Feederle, R. ; Schmidt, O. ; Abken, H. ; Protzer, U. ; Burdach, S. ; Richter, G.H.S.

Therapeutic potential of GPR64 specific CAR T cells in pediatric sarcomas.

Cancer Immunol. Res. 5 (2017)

Baldauf, H.M. ; Stegmann, L. ; Schwarz, S.M. ; Ambiel, I. ; Trotard, M. ; Martin, M. ; Burggraf, M. ; Lenzi, G.M. ; Lejk, H. ; Pan, X. ; Fregoso, O.I. ; Lim, E.S. ; Abraham, L. ; Nguyen, L.A. ; Rutsch, F. ; König, R. ; Kim, B. ; Emerman, M. ; Fackler, O.T.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Proc. Natl. Acad. Sci. U.S.A. 114, 2729-2734 (2017)

Seleznik, G.M. ; Reding, T. ; Peter, L. ; Gupta, A. ; Steiner, S.G. ; Sonda, S. ; Verbeke, C.S. ; Dejardin, E. ; Khatkov, I. ; Segerer, S. ; Heikenwälder, M. ; Graf, R.

Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.

Gut 67, 1663-1673 (2017)

Wolf, Y. ; Shemer, A. ; Polonsky, M. ; Gross, M. ; Mildner, A. ; Yona, S. ; David, E. ; Kim, K.W. ; Goldmann, T. ; Amit, I. ; Heikenwälder, M. ; Nedospasov, S.A. ; Prinz, M. ; Friedman, N. ; Jung, S.

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation.

J. Exp. Med. 214, 905-917 (2017)

Rosdahl, A. ; Herzog, C. ; Frösner, G. ; Norén, T. ; Rombo, L. ; Askling, H.H.

An extra priming dose of hepatitis A vaccine to adult patients with rheumatoid arthritis and drug induced immunosuppression - A prospective, open-label, multi-center study.

Travel Med. Infect. Dis. 21, 43-50 (2017)

Xia, Y. ; Stadler, D. ; Ko, C. ; Protzer, U.

Analyses of HBV cccDNA quantification and modification.

Methods Mol. Biol. 1540, 59-72 (2017)

Werner, J.M. ; Adenugba, A. ; Protzer, U.

Immune reconstitution after HCV clearance with direct antiviral agents: Potential consequences for patients with HCC?

Transplantation 101, 904-909 (2017)

Burwitz, B.J. ; Wettengel, J.M. ; Mück-Häusl, M.A. ; Ringelhan, M. ; Ko, C. ; Festag, M.M. ; Hammond, K.B. ; Northrup, M. ; Bimber, B.N. ; Jacob, T. ; Reed, J.S. ; Norris, R. ; Park, B. ; Moller-Tank, S. ; Esser, K. ; Greene, J.M. ; Wu, H.L. ; Abdulhaqq, S. ; Webb, G. ; Sutton, W.F. ; Klug, A. ; Swanson, T. ; Legasse, A.W. ; Vu, T.Q. ; Asokan, A. ; Haigwood, N.L. ; Protzer, U. ; Sacha, J.B.

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.

Nat. Commun. 8:2146 (2017)

Feichtmayer, J. ; Deng, L. ; Griebler, C.

Antagonistic microbial interactions: Contributions and potential applications for controlling pathogens in the aquatic systems.

Front. Microbiol. 8, 2192 (2017)

Inturi, R. ; Mun, K. ; Singethan, K. ; Schreiner, S. ; Punga, T.

Human adenovirus infection causes cellular E3 ubiquitin ligase MKRN1 degradation involving the viral core protein pVII.

J. Virol. 92:e01154-17 (2017)

Egaña, I. ; Kaito, H. ; Nitzsche, A. ; Becker, L. ; Ballester-Lopez, C. ; Niaudet, C. ; Petkova, M. ; Liu, W. ; Vandlandewijck, M. ; Vernaleken, A. ; Klopstock, T. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Rask-Andersen, H. ; Johansson, H.J. ; Lehtiö, J. ; He, L. ; Yildirim, A.Ö. ; Hellström, M. ; German Mouse Clinic Consortium (Aguilar-Pimentel, J.A. ; Ollert, M. ; Schmidt-Weber, C.B. ; Amarie, O.V. ; Graw, J. ; Beckers, J. ; Garrett, L. ; Hölter, S.M. ; Zimprich, A. ; Wurst, W. ; Moreth, K. ; Bekeredjian, R. ; Neff, F. ; Calzada-Wack, J. ; Rácz, I. ; Zimmer, A. ; Rathkolb, B. ; Wolf, E. ; Rozman, J. ; Klingenspor, M. ; Stöger, T. ; Eickelberg, O. ; Treise, I. ; Busch, D.H. ; Östereicher, M. ; Steinkamp, R. ; Lengger, C. ; Maier, H. ; Stöger, C. ; Leuchtenberger, S.)

Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.

Sci. Rep. 7:15453 (2017)

Li, Y. ; Xia, Y. ; Han, M. ; Chen, G. ; Zhang, D. ; Thasler, W.E. ; Protzer, U. ; Ning, Q.

IFN-α-mediated base excision repair pathway correlates with antiviral response against hepatitis B virus infection.

Sci. Rep. 7:12715 (2017)

Neuenhahn, M. ; Albrecht, J. ; Odendahl, M. ; Schlott, F. ; Doessinger, G. ; Schiemann, M. ; Lakshmipathi, S. ; Martin, K. ; Bunjes, D. ; Harsdorf, S. ; Weissinger, E.M. ; Menzel, H. ; Verbeek, M. ; Uharek, L. ; Kroeger, N. ; Wagner, E. ; Kobbe, G. ; Schroeder, T. ; Schmitt, M. ; Held, G. ; Herr, W. ; Germeroth, L. ; Bönig, H. ; Tonn, T. ; Einsele, H. ; Busch, D.H. ; Grigoleit, G.U.

Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT.

Leukemia 31, 2161-2171 (2017)

Hofmann, S. ; Dehn, S. ; Businger, R. ; Bolduan, S. ; Schneider, M. ; Debyser, Z. ; Brack-Werner, R. ; Schindler, M.

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication.

Open Biol. 7:170115 (2017)

Bolduan, S. ; Koppensteiner, H. ; Businger, R. ; Rebensburg, S. ; Kunze, C. ; Brack-Werner, R. ; Draenert, R. ; Schindler, M.

T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.

J. Int. AIDS Soc. 20:21865 (2017)

Ringelhan, M. ; McKeating, J.A. ; Protzer, U.

Viral hepatitis and liver cancer.

Philos. Trans. R. Soc. B - Biol. Sci. 372:20160274 (2017)

Boege, Y. ; Malehmir, M. ; Healy, M.E. ; Bettermann, K. ; Lorentzen, A.R. ; Vucur, M. ; Ahuja, A.K. ; Böhm, F. ; Mertens, J.C. ; Shimizu, Y. ; Frick, L. ; Remouchamps, C. ; Mutreja, K. ; Kähne, T. ; Sundaravinayagam, D. ; Wolf, M.J. ; Rehrauer, H. ; Koppe, C. ; Speicher, T. ; Padrissa-Altés, S. ; Maire, R. ; Schattenberg, J.M. ; Jeong, J.S. ; Liu, L. ; Zwirner, S. ; Boger, R.H. ; Hüser, N. ; Davis, R.J. ; Müllhaupt, B. ; Moch, H. ; Schulze-Bergkamen, H. ; Clavien, P.A. ; Werner, S. ; Borsig, L. ; Luther, S.A. ; Jost, P.J. ; Weinlich, R. ; Unger, K. ; Behrens, A. ; Hillert, L. ; Dillon, C. ; Di Virgilio, M. ; Wallach, D. ; Dejardin, E. ; Zender, L. ; Naumann, M. ; Walczak, H. ; Green, D.R. ; Lopes, M. ; Lavrik, I.N. ; Luedde, T. ; Heikenwälder, M. ; Weber, A.

A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.

Cancer Cell 32, 342-359.e10 (2017)

Wisskirchen, K. ; Metzger, K. ; Schreiber, S. ; Asen, T. ; Weigand, L. ; Dargel, C. ; Witter, K. ; Kieback, E. ; Sprinzl, M.F. ; Uckert, W. ; Schiemann, M. ; Busch, D.H. ; Krackhardt, A.M. ; Protzer, U.

Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.

PLoS ONE 12:e0182936 (2017)

Shevtsov, M. ; Zhao, L. ; Protzer, U. ; Klundert, M.A.A.

Applicability of metal nanoparticles in the detection and monitoring of hepatitis B virus infection.

Viruses 9:193 (2017)

Bergmann, H. ; Roth, S. ; Pechloff, K. ; Kiss, E.A. ; Kühn, S. ; Heikenwälder, M. ; Diefenbach, A. ; Greten, F.R. ; Ruland, J.

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.

Eur. J. Immunol. 47, 1342-1353 (2017)

Sautto, G.A. ; Diotti, R.A. ; Wisskirchen, K. ; Kahle, K.M.

New insights for immune-based diagnosis and therapy for infectious diseases.

J. Immunol. Res. 2017:3104719 (2017)

Hösel, M. ; Quasdorff, M. ; Ringelhan, M. ; Kashkar, H. ; Debey-Pascher, S. ; Sprinzl, M.F. ; Bockmann, J.H. ; Arzberger, S. ; Webb, D. ; von Olshausen, G. ; Weber, A. ; Schultze, J.L. ; Büning, H. ; Heikenwälder, M. ; Protzer, U.

Hepatitis B virus activates signal transducer and activator of transcription 3 supporting hepatocyte survival and virus replication.

Cell. Mol. Gast. Hept. 4, 339-363 (2017)

Protzer, U.

Visualizing HEV infection in human liver tissue.

J. Hepatol. 67, 471–479 (2017)

Kaminski, M. ; Grummel, V. ; Hoffmann, D. ; Berthele, A. ; Hemmer, B.

The spectrum of aseptic central nervous system infections in southern Germany - demographic, clinical and laboratory findings.

Eur. J. Neurol. 24, 1062-1070 (2017)

Golsaz-Shirazi, F. ; Amiri, M.M. ; Farid, S. ; Bahadori, M. ; Bohne, F. ; Altstetter, S. ; Wolff, L. ; Kazemi, T. ; Khoshnoodi, J. ; Hojjat-Farsangi, M. ; Chudy, M. ; Jeddi-Tehrani, M. ; Protzer, U. ; Shokri, F.

Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).

Antiviral Res. 144, 153-163 (2017)

Schreiner, S. ; Nassal, M.

A role for the host DNA damage response in Hepatitis B Virus cccDNA formation-and beyond?

Viruses 9:E125 (2017)

Schlenker, R. ; Olguín-Contreras, L.F. ; Leisegang, M. ; Schnappinger, J. ; Disovic, A. ; Rühland, S. ; Nelson, P.J. ; Leonhardt, H. ; Harz, H. ; Wilde, S. ; Schendel, D.J. ; Uckert, W. ; Willimsky, G. ; Nößner, E.

Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy.

Cancer Res. 77, 3577-3590 (2017)

Ko, C. ; Michler, T. ; Protzer, U.

Novel viral and host targets to cure hepatitis B.

Curr. Opin. Virol. 24, 38-45 (2017)

Hanin, G. ; Yayon, N. ; Tzur, Y. ; Haviv, R. ; Bennett, E.R. ; Udi, S. ; Krishnamoorthy, Y.R. ; Kotsiliti, E. ; Zangen, R. ; Efron, B. ; Tam, J. ; Pappo, O. ; Shteyer, E. ; Pikarsky, E. ; Heikenwälder, M. ; Greenberg, D.S. ; Soreq, H.

miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.

Gut 67, 1124-1134 (2017)

Yuan, D.T. ; Ringelhan, M. ; Connor, T.O. ; Simonavicius, N. ; Reisinger, F. ; Leone, V. ; Protzer, U. ; Unger, K. ; Heikenwälder, M.

Kupffer cell-derived Tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS.

Cancer Cell 31, 771-789.e6 (2017)

Protzer, U.

Viral hepatitis: The bumpy road to animal models for HBV infection.

Nat. Rev. Gastroenterol. Hepatol. 14, 327-328 (2017)

Michler, T. ; Kosinska, A. ; Bunse, T. ; Heikenwälder, M. ; Grimm, D. ; Milstein, S. ; Sepp-Lorenzino, L. ; Protzer, U.

Preclinical study of a combinatorial RNAi/vaccination therapy as a potential cure for chronic hepatitis B.

J. Hepatol. 66, S112-S112 (2017)

Wisskirchen, K. ; Kah, J. ; Metzger, K. ; Weigand, L. ; Uckert, W. ; Schiemann, M. ; Volz, T. ; Krackhardt, A. ; Dandri, M. ; Protzer, U.

Hepatitis B virus-specific T cell receptors with high functional avidity redirect T cells to eliminate HBV.

J. Hepatol. 66, S29-S30 (2017)

Sissoko, D. ; Keita, M. ; Diallo, B. ; Aliabadi, N. ; Fitter, D.L. ; Dahl, B.A. ; Bore, J.A. ; Koundouno, F.R. ; Singethan, K. ; Meisel, S. ; Enkirch, T. ; Mazzarelli, A. ; Amburgey, V. ; Faye, O. ; Sall, A.A. ; Magassouba, N. ; Carroll, M.W. ; Anglaret, X. ; Malvy, D. ; Formenty, P. ; Aylward, R.B. ; Keita, S. ; Djingarey, M.H. ; Loman, N.J. ; Guenther, S. ; Duraffour, S.

Ebola virus persistence in breast milk after no reported illness: A likely source of virus transmission from mother to child.

Clin. Infect. Dis. 64, 513-516 (2017)

Appelman, M.D. ; Chakraborty, A. ; Protzer, U. ; McKeating, J.A. ; van de Graaf, S.F.J.

N-glycosylation of the Na+-taurocholate cotransporting polypeptide (NTCP) determines its trafficking and stability and is required for hepatitis B Vvrus infection.

PLoS ONE 12:e0170419 (2017)

Schlott, F. ; Steubl, D. ; Hoffmann, D. ; Matevossian, E. ; Lutz, J. ; Heemann, U. ; Hösel, V. ; Busch, D.H. ; Renders, L. ; Neuenhahn, M.

Primary cytomegalovirus infection in seronegative kidney transplant patients is associated with protracted cold ischemic time of seropositive donor organs.

PLoS ONE 12:e0171035 (2017)

Xia, Y. ; Cheng, X. ; Blossey, C.K. ; Wisskirchen, K. ; Esser, K. ; Protzer, U.

Secreted interferon-inducible factors restrict hepatitis B and C virus entry in vitro.

J. Immunol. Res. 2017:4828936 (2017)

Yuan, D.T. ; Heikenwälder, M.

Kupffer cell-derived TNF triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS.

In: (Molecular chaperones in cancer, 2-4 May 2017, Madrid). 2017. S. 51

Xia, Y. ; Protzer, U.

Control of hepatitis B virus by cytokines.

Viruses 9:18 (2017)

Smida, J. ; Xu, H. ; Zhang, Y. ; Baumhoer, D. ; Ribi, S. ; Kovac, M. ; von Luettichau, I. ; Bielack, S. ; O'Leary, V.B. ; Leib-Mösch, C. ; Frishman, D. ; Nathrath, M.

Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma.

Int. J. Cancer 141, 816-828 (2017)

Zhang, W. ; Chen, J. ; Wu, M. ; Zhang, X. ; Zhang, M. ; Yue, L. ; Li, Y. ; Liu, J. ; Li, B. ; Shen, F. ; Wang, Y. ; Bai, L. ; Protzer, U. ; Levrero, M. ; Yuan, Z.

PRMT5 restricts hepatitis B virus replication via epigenetic repression of cccDNA transcription and interference with pgRNA encapsidation.

Hepatology 66, 398-415 (2017)

Kosinska, A. ; Bauer, T. ; Protzer, U.

Therapeutic vaccination for chronic hepatitis B.

Curr. Opin. Virol. 23, 75-81 (2017)

Entfellner, E. ; Frei, M. ; Christiansen, G. ; Deng, L. ; Blom, J. ; Kurmayer, R.

Evolution of anabaenopeptin peptide structural variability in the cyanobacterium planktothrix.

Front. Microbiol. 8:219 (2017)

Zhernov, Y.V. ; Kremb, S. ; Helfer, M. ; Schindler, M. ; Harir, M. ; Mueller, C. ; Hertkorn, N. ; Avvakumova, N.P. ; Konstantinov, A.I. ; Brack-Werner, R. ; Schmitt-Kopplin, P. ; Perminova, I.V.

Supramolecular combinations of humic polyanions as potent microbicides with polymodal anti-HIV-activities.

New J. Chem. 41, 212-224 (2017)

Xia, Y. ; Carpentier, A. ; Cheng, X. ; Block, P.D. ; Zhao, Y. ; Zhang, Z. ; Protzer, U. ; Jake Liang, T.

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

J. Hepatol. 66, 494-503 (2017)

Bohne, F. ; Quitt, O. ; Hasreiter, J. ; Luo, S. ; Bockmann, J.H. ; Tedjokusumo, R. ; Momburg, F. ; Protzer, U.

BI-and trispecific antibodyconstructs mediate specific TCell retargeting towards and elimination of HBV-positive hepatocytes and tumor cells.

J. Hepatol. 64, S387-S387 (2016)

Xia, Y. ; Carpentier, A. ; Zhang, Z. ; Protzer, U. ; Liang, T.J.

Hepatitis B virus infection of human stem cells-derived hepatocyte-like cells.

J. Hepatol. 64, S398-S398 (2016)

Karimzadeh, H. ; Budeus, B. ; Kosinska, A. ; Bauer, T. ; Heinold, A. ; Hoffmann, D. ; Protzer, U. ; Roggendorf, M.

Correlation of mutations within HDV-protein with HLA Backgrounds of patients leads to identification of novel CD8 T cell epitopes.

J. Hepatol. 64, S361-S361 (2016)

Koppe, C. ; Reisinger, F. ; Verheugd, P. ; Gautheron, J. ; Roderburg, C. ; Tacke, F. ; Preisinger, C. ; Luescher, B. ; Vucur, M. ; Trautwein, C. ; Heikenwälder, M. ; Luedde, T.

Ikkalpha/beta regulate hepatocarcinogenesis and biliary homeostasis by controlling RIPK1 activity.

J. Hepatol. 64, S312-S313 (2016)

Michler, T. ; Kosinska, A. ; Jager, C. ; Röder, N. ; Grimm, D. ; Heikenwälder, M. ; Roggendorf, M. ; Protzer, U.

RNA interference mediated suppression of HBV transcripts restores HBV-specific immunity and enhances the efficacy of therapeutic vaccination.

J. Hepatol. 64, S148-S149 (2016)

Tao, S. ; Tao, R. ; Patra, M. ; Drexler, I.

The subcellular localization of viral antigen after infection shapes the antigenic profile and protective capacity of poxvirus-mediated T cell immunity.

Eur. J. Immunol. 46, 1, 339-339 (2016)

Greiner, T. ; Bolduan, S. ; Hertel, B. ; Groß, C. ; Hamacher, K. ; Schubert, U. ; Moroni, A. ; Thiel, G.

Ion channel activity of Vpu proteins is conserved throughout evolution of HIV-1 and SIV.

Viruses 8:325 (2016)

Ben-Neriah, Y. ; Lasrey, A. ; Aran, D. ; Zinger, A. ; Finkin, S. ; Stein, I. ; Yuan, D.T. ; Hellman, A. ; Heikenwälder, M. ; Pikarsky, E.

A variety of cancer-associated inflammatory reactions.

FEBS J. 283, 24-24 (2016)

Pikarsky, E. ; Heikenwälder, M.

Focal and Local: Ectopic lymphoid structures and aggregates of myeloid and other immune cells in liver.

Gastroenterology 151, 780-783 (2016)

Muschaweckh, A. ; Buchholz, V.R. ; Fellenzer, A. ; Hessel, C. ; König, P.A ; Tao, S. ; Tao, R. ; Heikenwälder, M. ; Busch, D.H. ; Korn, T. ; Kastenmüller, G. ; Drexler, I. ; Gasteiger, G.

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8⁺ T cells.

J. Exp. Med. 213, 3075-3086 (2016)

Mayorga, O. ; Bühler, S. ; Jaeger, V.K. ; Bally, S. ; Hatz, C. ; Frösner, G. ; Protzer, U. ; van Damme, P. ; Egger, M. ; Herzog, C.

Single-dose Hepatitis A immunization: 7.5-year observational pilot study in nicaraguan children to assess protective effectiveness and humoral immune memory response.

J. Infect. Dis. 214, 1498-1506 (2016)

Li, Y. ; Xia, Y. ; Han, M. ; Chen, G. ; Zhang, D. ; Thasler, W.E. ; Protzer, U. ; Ning, Q.

IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

Hepatology 63, 1, 921A-921A (2016)

Koppe, C. ; Gautheron, J. ; Vucur, M. ; Roderburg, C. ; Tacke, F. ; Trautwein, C. ; Heikenwälder, M. ; Luedde, T.

A new molecular interaction between IKK alpha/beta and RIPK1 regulates biliary homeostasis and hepatocarcinogenesis.

Hepatology 63, 1, 257A-258A (2016)

Sunami, Y. ; Ringelhan, M. ; Kokai, E. ; Lu, M. ; O'Connor, T. ; Lorentzen, A.R. ; Weber, A. ; Rodewald, A. ; Müllhaupt, B. ; Terracciano, L. ; Gul, S. ; Wissel, S. ; Leithäuser, F. ; Krappmann, D. ; Riedl, P. ; Hartmann, D. ; Schirmbeck, R. ; Strnad, P. ; Hüser, N. ; Kleeff, J. ; Friess, H. ; Schmid, R.M. ; Geisler, F. ; Wirth, T. ; Heikenwälder, M.

Canonical NF-kappa B signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Hepatology 63, 1, 233A-233A (2016)

Rollier, C.S. ; Verschoor, E.J. ; Verstrepen, B.E. ; Drexhage, J.A.R. ; Paranhos-Baccala, G. ; Liljeström, P. ; Sutter, G. ; Arribillaga, L. ; Lasarte, J.J. ; Bartosch, B. ; Cosset, F.L. ; Inchauspe, G. ; Heeney, J.L.

T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.

Gene Ther. 23, 753-759 (2016)

Berger, E. ; Rath, E. ; Yuan, D.T. ; Waldschmitt, N. ; Khaloian, S. ; Allgäuer, M. ; Staszewski, O. ; Lobner, E.M. ; Schöttl, T. ; Giesbertz, P. ; Coleman, O.I. ; Prinz, M. ; Weber, A. ; Gerhard, M. ; Klingenspor, M. ; Janssen, K.P. ; Heikenwälder, M. ; Haller, D.

Mitochondrial function controls intestinal epithelial stemness and proliferation.

Nat. Commun. 7:13171 (2016)

Lehmann, J. ; Vomacka, J. ; Esser, K. ; Nodwell, M. ; Kolbe, K. ; Raemer, P. ; Protzer, U. ; Reiling, N. ; Sieber, S.A.

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases.

MedChemComm 7, 1797-1801 (2016)

Eggert, T. ; Wolter, K. ; Ji, J. ; Ma, C. ; Yevsa, T. ; Klotz, S. ; Medina-Echeverz, J. ; Longerich, T. ; Forgues, M. ; Reisinger, F. ; Heikenwälder, M. ; Wang, X.W. ; Zender, L. ; Greten, T.F.

Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression.

Cancer Cell 30, 533-547 (2016)

Brinkmann, C. ; Nehlmeier, I. ; Walendy-Gnirß, K. ; Nehls, J. ; González Hernández, M. ; Hoffmann, M. ; Qiu, X. ; Takada, A. ; Schindler, M. ; Pöhlmann, S.

Tetherin antagonism by the Ebola virus glycoprotein requires an intact receptor-binding domain and can be blocked by GP1-specific antibodies.

J. Virol. 90, 11075-11086 (2016)

Protzer, U. ; Knolle, P.A.

"To be or not to be": Immune tolerance in chronic hepatitis B.

Gastroenterology 151, 805-806 (2016)

Gaber, H. ; Abdellatif, A.

Liver research in the International Space Station.

Arab. J. Gastroenterol. 17, 111-112 (2016)

Göttesdorfer, I.

Identifizierung transkriptionell aktivierter humaner endogener Retroviren (HERVs) in Tumorerkrankungen.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2016, 166 S.

Jager, C.

Therapeutic vaccination using MVA-vectors in a murine model of chronic HBV infection.

München, Technische Universität, Fakultät für Medizin, Diss., 2016, 140S.

Yuan, D.T.

Investigation of environmental and epigenetic etiologies driving cholangiolar and hepatocellular neoplasias.

München, Technische Universität, Fakultät für Medizin, Diss., 2016, 128 S.

Bayer, K. ; Banning, C. ; Bruss, V. ; Wiltzer-Bach, L. ; Schindler, M.

Hepatitis C virus is released via a non-canonical secretory route.

J. Virol. 90, 10558-10573 (2016)

Boeckl, K. ; Körber, N. ; Barabas, S. ; Demi, L. ; Bauer, T.

An optimized IFN-gamma ELISpot assay using T-activated (R) proteins for determination of CMV-specific cell-mediated immunity.

J. Immunol. 196, 1 (2016)

Mayorga, O. ; Bühler, S. ; Jaeger, V.K. ; Bally, S. ; Hatz, C. ; Frösner, G. ; Protzer, U. ; van Damme, P. ; Egger, M. ; Herzog, C.

Single dose hepatitis A immunisation: 7.5 year observational pilot study in Nicaraguan children to assess protective effectiveness and humoral immune memory response.

J. Infect. Dis. 214, 1498-1506 (2016)

Scherr, A.L. ; Gdynia, G. ; Salou, M. ; Radhakrishnan, P. ; Duglova, K. ; Heller, A. ; Keim, S. ; Kautz, N. ; Jassowicz, A. ; Elssner, C. ; He, Y.W. ; Jaeger, D. ; Heikenwälder, M. ; Schneider, M. ; Weber, A. ; Roth, W. ; Schulze-Bergkamen, H. ; Koehler, B.C.

Bcl-x_L is an oncogenic driver in colorectal cancer.

Cell Death Dis. 7:e2342 (2016)

Wolf, B. ; Krieg, K. ; Falk, C. ; Breuhahn, K. ; Keppeler, H. ; Biedermann, T. ; Schmid, E. ; Warmann, S. ; Fuchs, J. ; Vetter, S. ; Thiele, D. ; Nieser, M. ; Avci-Adali, M. ; Skokowa, Y. ; Schöls, L. ; Hauser, S.L. ; Ringelhan, M. ; Yevsa, T. ; Heikenwälder, M. ; Kossatz-Boehlert, U.

Inducing differentiation of premalignant hepatic cells as a novel therapeutic strategy in hepatocarcinoma.

Cancer Res. 76, 5550-5561 (2016)

Lesina, M. ; Wörmann, S.M. ; Morton, J. ; Diakopoulos, K.N. ; Korneeva, O. ; Wimmer, M. ; Einwächter, H. ; Sperveslage, J. ; Demir, I.E. ; Kehl, T. ; Saur, D. ; Sipos, B. ; Heikenwälder, M. ; Steiner, J.M. ; Wang, T.C. ; Sansom, O.J. ; Schmid, R.M. ; Algül, H.

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

J. Clin. Invest. 126, 2919-2932 (2016)

Saito, Y. ; Ellegast, J.M. ; Rafiei, A. ; Song, Y. ; Kull, D. ; Heikenwälder, M. ; Rongvaux, A. ; Halene, S. ; Flavell, R.A. ; Manz, M.G.

Peripheral blood CD34⁺ cells efficiently engraft human cytokine knock-in mice.

Blood 128, 1829-1833 (2016)

Endig, J. ; Buitrago-Molina, L.E. ; Marhenke, S. ; Reisinger, F. ; Saborowski, A. ; Schütt, J. ; Limbourg, F. ; Könecke, C. ; Schreder, A. ; Michael, A. ; Misslitz, A.C. ; Healy, M.E. ; Geffers, R. ; Clavel, T. ; Haller, D. ; Unger, K. ; Finegold, M. ; Weber, A. ; Manns, M.P. ; Longerich, T. ; Heikenwälder, M. ; Vogel, A.

Dual role of the adaptive immune system in liver injury and hepatocellular carcinoma development.

Cancer Cell 30, 308-323 (2016)

Rivkin, M. ; Simerzin, A. ; Zorde-Khvalevsky, E. ; Chai, C. ; Yuval, J.B. ; Rosenberg, N. ; Harari-Steinfeld, R. ; Schneider, R. ; Amir, G. ; Condiotti, R. ; Heikenwälder, M. ; Weber, A. ; Schramm, C. ; Wege, H. ; Kluwe, J. ; Galun, E. ; Giladi, H.

Inflammation-induced expression and secretion of microRNA 122 leads to reduced blood levels of kidney-derived erythropoietin and anemia.

Gastroenterology 151, 999-1010.e3 (2016)

Michler, T. ; Große, S. ; Mockenhaupt, S. ; Röder, N. ; Stückler, F. ; Knapp, B. ; Ko, C. ; Heikenwälder, M. ; Protzer, U. ; Grimm, D.

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

EMBO Mol. Med. 8, 1082-1098 (2016)

Schirmer, D. ; Gruenewald, T.G.P. ; Klar, R. ; Schmidt, O. ; Wohlleber, D. ; Rubio, R.A. ; Uckert, W. ; Thiel, U. ; Bohne, F. ; Busch, D.H. ; Krackhardt, A.M. ; Burdach, S. ; Richter, G.H.S.

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.

OncoImmunology 5:e1175795 (2016)

Hagemeyer, N. ; Kierdorf, K. ; Frenzel, K. ; Xue, J. ; Ringelhan, M. ; Abdullah, Z. ; Godin, I. ; Wieghofer, P. ; Costa Jordão, M.J. ; Ulas, T. ; Yorgancioglu, G. ; Rosenbauer, F. ; Knolle, P.A. ; Heikenwälder, M. ; Schultze, J.L. ; Prinz, M.

Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.

EMBO J. 35, 1730-1744 (2016)

Höckendorf, U. ; Yabal, M. ; Herold, T. ; Munkhbaatar, E. ; Rott, S. ; Jilg, S. ; Kauschinger, J. ; Magnani, G. ; Reisinger, F. ; Heuser, M. ; Kreipe, H. ; Sotlar, K. ; Engleitner, T. ; Rad, R. ; Weichert, W. ; Peschel, C. ; Ruland, J. ; Heikenwälder, M. ; Spiekermann, K. ; Slotta-Huspenina, J. ; Groß, O. ; Jost, P.J.

RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells.

Cancer Cell 30, 75-91 (2016)

Weber, A. ; Heikenwälder, M.

P(URI)fying novel drivers of NASH and HCC: A feedforward loop of IL17A via white adipose tissue.

Cancer Cell 30, 15-17 (2016)

Koppe, C. ; Verheugd, P. ; Gautheron, J. ; Reisinger, F. ; Kreggenwinkel, K. ; Roderburg, C. ; Quagliata, L. ; Terracciano, L. ; Gassler, N. ; Tolba, R.H. ; Boege, Y. ; Weber, A. ; Karin, M. ; Luedde, M. ; Neumann, U.P. ; Weiskirchen, R. ; Tacke, F. ; Vucur, M. ; Trautwein, C. ; Lüscher, B. ; Preisinger, C. ; Heikenwälder, M. ; Luedde, T.

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Hepatology 64, 1217-1231 (2016)

Chachage, M. ; Pollakis, G. ; Kuffour, E.O. ; Haase, K. ; Bauer, A. ; Nadai, Y. ; Podola, L. ; Clowes, P. ; Schiemann, M. ; Henkel, L. ; Hoffmann, D. ; Joseph, S.S. ; Bhuju, S. ; Maboko, L. ; Sarfo, F.S. ; Eberhardt, K. ; Hoelscher, M. ; Feldt, T. ; Saathoff, E. ; Geldmacher, C.

CD25⁺ FoxP3⁺ memory CD4 T cells are frequent targets of HIV infection in vivo.

J. Virol. 90, 8954-8967 (2016)

Höhne, K. ; Businger, R. ; van Nuffel, A. ; Bolduan, S. ; Koppensteiner, H. ; Baeyens, A. ; Vermeire, J. ; Malatinkova, E. ; Verhasselt, B. ; Schindler, M.

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection.

Open Biol. 6:160046 (2016)

Homs, M. ; Rodriguez-Frias, F. ; Gregori, J. ; Ruiz, A. ; Reimundo, P. ; Casillas, R. ; Tabernero, D. ; Godoy, C. ; Barakat, S. ; Quer, J. ; Riveiro-Barciela, M. ; Roggendorf, M. ; Esteban, R. ; Buti, M.

Evidence of an exponential decay pattern of the hepatitis delta virus evolution rate and fluctuations in quasispecies complexity in long-term studies of chronic delta infection.

PLoS ONE 11:e0158557 (2016)

Späth, P.M. ; Hoffmann, D. ; Spitzenberger, F.

Der Einfluss der DIN EN ISO 15189 auf die Ergebnissicherheit in der Virusdiagnostik.

Lab. Med. 40, 155-164 (2016)

Broadley, S.P. ; Plaumann, A. ; Coletti, R. ; Lehmann, C. ; Wanisch, A. ; Seidlmeier, A. ; Esser, K. ; Luo, S. ; Rämer, P.C. ; Massberg, S. ; Busch, D.H. ; van Lookeren Campagne, M. ; Verschoor, A.

Dual-track clearance of circulating bacteria balances rapid restoration of blood sterility with induction of adaptive immunity.

Cell Host Microbe 20, 36-48 (2016)

Thomsen, M.K. ; Nandakumar, R. ; Stadler, D. ; Malo, A. ; Valls, R.M. ; Wang, F. ; Reinert, L.S. ; Dagnaes-Hansen, F. ; Hollensen, A.K. ; Mikkelsen, J.G. ; Protzer, U. ; Paludan, S.R.

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.

Hepatology 64, 746-759 (2016)

Wisskirchen, K. ; Metzger, K. ; Weigand, L. ; Kieback, E. ; Sprinzl, M. ; Uckert, W. ; Busch, D.H. ; Krackhardt, A.M. ; Protzer, U.

Functional characterization of OF HBV-specific T cell receptors for redirection of T cells against HBV-infected hepatocytes.

Cytotherapy 18, S15-S16 (2016)

Körber, N. ; Behrends, U. ; Hapfelmeier, A. ; Protzer, U. ; Bauer, T.

Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring.

J. Transl. Med. 14:175 (2016)

Spinner, S. ; Crispatzu, G. ; Yi, J.H. ; Munkhbaatar, E. ; Mayer, P. ; Höckendorf, U. ; Müller, N. ; Li, Z. ; Schader, T. ; Bendz, H. ; Hartmann, S. ; Yabal, M. ; Pechloff, K. ; Heikenwälder, M. ; Kelly, G.L. ; Strasser, A. ; Peschel, C. ; Hansmann, M.L. ; Ruland, J. ; Keller, U. ; Newrzela, S. ; Herling, M. ; Jost, P.J.

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.

Leukemia 30, 1520-1530 (2016)

Mejías-Luque, R. ; Zöller, J. ; Anderl, F. ; Loew-Gil, E. ; Vieth, M. ; Adler, T. ; Engler, D.B. ; Urban, S. ; Browning, J.L. ; Müller, A. ; Gerhard, M. ; Heikenwälder, M.

Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.

Gut 66, 1369-1381 (2016)

Blank, T. ; Detje, C.N. ; Spieß, A. ; Hagemeyer, N. ; Brendecke, S.M. ; Wolfart, J. ; Staszewski, O. ; Zöller, T. ; Papageorgiou, I. ; Schneider, J. ; Paricio-Montesinos, R. ; Eisel, U.L. ; Manahan-Vaughan, D. ; Jansen, S. ; Lienenklaus, S. ; Lu, B. ; Imai, Y. ; Müller, M. ; Goelz, S.E. ; Baker, D.P. ; Schwaninger, M. ; Kann, O. ; Heikenwälder, M. ; Kalinke, U. ; Prinz, M.

Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment.

Immunity 44, 901-912 (2016)

Blondot, M.L. ; Bruss, V. ; Kann, M.

Intracellular transport and egress of hepatitis B virus.

J. Hepatol. 64, S49-S59 (2016)

Lucifora, J. ; Protzer, U.

Attacking hepatitis B virus cccDNA - the holy grail to hepatitis B cure.

J. Hepatol. 64, S41-S48 (2016)

Neff, F. ; Kirsch, D.G. ; Saur, D. ; Schmid, R.M. ; Bazhin, A.V. ; Heikenwälder, M. ; Siveke, J.T.

Targeting notch for myeloid reprogramming in pancreatic cancer.

Oncol. Res. Treat. 39, 16 (2016)

Friemel, I. ; Rechsteiner, M.P. ; Frick, L. ; Boehm, F. ; Struckmann, K. ; Egger, M. ; Moch, N. ; Heikenwälder, M. ; Weber, A.

Intratumor heterogeneity in hepatocellular carcinoma: Impact on tumor classifications and targeted therapies.

Oncol. Res. Treat. 39, 81 (2016)

Beyer, M. ; Abdullah, Z. ; Chemnitz, J.M. ; Maisel, D. ; Sander, J. ; Lehmann, C. ; Thabet, Y. ; Shinde, P.V. ; Schmidleithner, L. ; Köhne, M. ; Trebicka, J. ; Schierwagen, R. ; Hofmann, A. ; Popov, A. ; Lang, K.S. ; Oxenius, A. ; Buch, T. ; Kurts, C. ; Heikenwälder, M. ; Fätkenheuer, G. ; Lang, P.A. ; Hartmann, P. ; Knolle, P.A. ; Schultze, J.L.

Tumor-necrosis factor impairs CD4⁺T cell-mediated immunological control in chronic viral infection.

Nat. Immunol. 17, 593-603 (2016)

Ma, C. ; Kesarwala, A.H. ; Eggert, T. ; Medina-Echeverz, J. ; Kleiner, D.E. ; Jin, P. ; Stroncek, D.F. ; Terabe, M. ; Kapoor, V. ; ElGindi, M. ; Han, M. ; Thornton, A.M. ; Zhang, H. ; Egger, M. ; Luo, J. ; Felsher, D.W. ; McVicar, D.W. ; Weber, A. ; Heikenwälder, M. ; Greten, T.F.

NAFLD causes selective CD4⁺ T lymphocyte loss and promotes hepatocarcinogenesis.

Nature 531, 253-257 (2016)

Broecker, F. ; Hardt, C. ; Herwig, R. ; Timmermann, B. ; Kerick, M. ; Wunderlich, A. ; Schweiger, M.R. ; Borsig, L. ; Heikenwälder, M. ; Lehrach, H. ; Moelling, K.

Transcriptional signature induced by a C-terminal c-Src mutant in a human breast cell line.

FEBS J. 283, 1669-1688 (2016)

Matter, M.S. ; Marquardt, J.U. ; Andersen, J.B. ; Quintavalle, C. ; Korokhov, N. ; Stauffer, J.K. ; Kaji, K. ; Decaens, T. ; Quagliata, L. ; Elloumi, F. ; Hoang, T. ; Molinolo, A. ; Conner, E.A. ; Weber, A. ; Heikenwälder, M. ; Factor, V.M. ; Thorgeirsson, S.S.

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.

Hepatology 63, 1888-1899 (2016)

Maresch, R. ; Müller, S. ; Veltkamp, C. ; Öllinger, R. ; Friedrich, M. ; Heid, I.M. ; Steiger, K. ; Weber, J. ; Engleitner, T. ; Barenboim, M. ; Klein, S. ; Louzada, S. ; Banerjee, R. ; Strong, A. ; Stauber, T. ; Gross, N. ; Geumann, U. ; Lange, S. ; Ringelhan, M. ; Varela, I. ; Unger, K. ; Yang, F. ; Schmid, R.M. ; Vassiliou, G.S. ; Braren, R. ; Schneider, G. ; Heikenwälder, M. ; Bradley, A. ; Saur, D. ; Rad, R.

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.

Nat. Commun. 7:10770 (2016)

Sunami, Y. ; Ringelhan, M. ; Kokai, E. ; Lu, M. ; O'Connor, T. ; Lorentzen, A.R. ; Weber, A. ; Rodewald, A.K. ; Müllhaupt, B. ; Terracciano, L. ; Gul, S. ; Wissel, S. ; Leithäuser, F. ; Krappmann, D. ; Riedl, P. ; Hartmann, D. ; Schirmbeck, R. ; Strnad, P. ; Hüser, N. ; Kleeff, J. ; Friess, H. ; Schmid, R.M. ; Geisler, F. ; Wirth, T. ; Heikenwälder, M.

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in HBV surface antigen-driven HCC by controlling the UPR.

Hepatology 63, 1592-1607 (2016)

O'Rourke, A. ; Kremb, S. ; Bader, T.M. ; Helfer, M. ; Schmitt-Kopplin, P. ; Gerwick, W.H. ; Brack-Werner, R. ; Voolstra, C.R.

Alkaloids from the sponge Stylissa carteri present prospective scaffolds for the inhibition of Human Immunodeficiency Virus 1 (HIV-1).

Mar. Drugs 14:28 (2016)

Saugel, B. ; Jakobus, J. ; Huber, W. ; Hoffmann, D. ; Holzapfel, K. ; Protzer, U. ; Schmid, R.M. ; Umgelter, A.

Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome.

J. Crit. Care 32, 138-144 (2016)

Rebensburg, S. ; Helfer, M. ; Schneider, M. ; Koppensteiner, H. ; Eberle, J. ; Schindler, M. ; Gürtler, L. ; Brack-Werner, R.

Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins.

Sci. Rep. 6:20394 (2016)

Roblek, M. ; Strutzmann, E. ; Zankl, C. ; Adage, T. ; Heikenwälder, M. ; Atlic, A. ; Weis, R. ; Kungl, A. ; Borsig, L.

Targeting of CCL2-CCR2-glycosaminoglycan axis using a CCL2 decoy protein attenuates metastasis through inhibition of tumor cell seeding.

Neoplasia 18, 49-59 (2016)

Backes, S. ; Jager, C. ; Dembek, C.J. ; Kosinska, A. ; Bauer, T. ; Stephan, A.-S. ; Dišlers, A. ; Mutwiri, G. ; Busch, D.H. ; Babiuk, L.A. ; Gasteiger, G. ; Protzer, U.

Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice.

Vaccine 34, 923-932 (2016)

Geipel, A. ; Seiz, P.L. ; Niekamp, H. ; Neumann-Fraune, M. ; Zhang, K. ; Kaiser, R. ; Protzer, U. ; Gerlich, W.H. ; Glebe, D. ; HOPE Consortium

Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.

Antivir. Ther. (Lond.) 20, 779-787 (2016)

Bonaccorsi-Riani, E. ; Pennycuick, A. ; Londoño, M.C. ; Lozano, J.J. ; Benítez, C. ; Sawitzki, B. ; Martínez-Picola, M. ; Bohne, F. ; Martínez-Llordella, M. ; Miquel, R. ; Rimola, A. ; Sánchez-Fueyo, A.

Molecular characterization of acute cellular rejection occurring during intentional immunosuppression withdrawal in liver transplantation.

Am. J. Transplant. 16, 484-496 (2016)

Hoellein, A. ; Hecker, J. ; Hoffmann, D. ; Göttle, F. ; Protzer, U. ; Peschel, C. ; Götze, K.

Serious outbreak of human metapneumovirus in patients with hematologic malignancies.

Leuk. Lymphoma 57, 623-627 (2016)

Wimmer, P. ; Berscheminski, J. ; Blanchette, P. ; Groitl, P. ; Branton, P.E. ; Hay, R.T. ; Dobner, T. ; Schreiner, S.

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

Oncogene 35, 69–82 (2016)

Nowicka, A.M. ; Häuselmann, I. ; Borsig, L. ; Bolduan, S. ; Schindler, M. ; Schraml, P. ; Heikenwälder, M. ; Moch, H.

A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.

Oncogene 35, 3125-3138 (2016)

Berscheminski, J. ; Brun, J. ; Speiseder, T. ; Wimmer, P. ; Ip, W.H. ; Terzic, M. ; Dobner, T. ; Schreiner, S.

Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation.

Oncogene 35, 3178-3189 (2016)

Meredith, L.W. ; Hu, K. ; Cheng, X. ; Howard, C.R. ; Baumert, T.F. ; Balfe, P. ; van de Graaf, K.F. ; Protzer, U. ; McKeating, J.A.

Lentiviral hepatitis B pseudotype entry requires NTCP and additional hepatocyte-specific factors.

J. Gen. Virol. 97, 121-127 (2016)

Sautto, G.A. ; Wisskirchen, K. ; Clementi, N. ; Castelli, M. ; Diotti, R.A. ; Graf, J. ; Clementi, M. ; Burioni, R. ; Protzer, U. ; Mancini, N.

Chimeric Antigen Receptor (CAR)-engineered T cells redirected against Hepatitis C Virus (HCV) E2 glycoprotein.

Gut 65, 512-523 (2016)

Zhang, E. ; Kosinska, A. ; Lu, M. ; Yan, H. ; Roggendorf, M.

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA.

Antiviral Res. 123, 193-203 (2015)

Garnelo, M. ; Tan, A. ; Her, Z. ; Yeong, J. ; Lim, C.J. ; Chen, J. ; Lim, K.H. ; Weber, A. ; Chow, P. ; Chung, A. ; Ooi, L.L. ; Toh, H.C. ; Heikenwälder, M. ; Ng, I.O. ; Nardin, A. ; Chen, Q. ; Abastado, J.-P. ; Chew, V.

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Gut 66, 342-351 (2015)

Cheng, X.

The role of non-parenchymal liver cells in early hepatitis B virus and hepatitis C virus infection.

München, Technische Universität, Fakultät für Medizin, Diss., 2015, 158 S.

Russo, C.

Functional and phenotypic characterization of CD4 T cells involved in immunopathogenesis of hepatitis B virus infection.

München, Technische Universität, Fakultät für Medizin, Diss., 2015, 91 S.

Graessel, A. ; Hauck, S.M. ; von Toerne, C. ; Kloppmann, E. ; Goldberg, T. ; Koppensteiner, H. ; Schindler, M. ; Knapp, B. ; Krause, L. ; Kremmer, E. ; Blank, S. ; Schmidt-Weber, C.B. ; Suttner, K.

Identification of new cell surface proteins on human naive CD4⁺ T-cells potentially involved in the early T-cell activation.

Allergy 70, 104 (2015)

Ebinger, S. ; Erbey, O. ; Tiedt, S. ; Ziegenhain, C. ; Alves, C.C. ; Enard, W. ; Jeremias, I.

Single cell RNA sequencing reveals increased adhesion signals in treatment-resistant tumor stem cells in a preclinical mouse model of genetically engineered patient-derived acute lymphoblastic leukemia.

Blood 126:2630 (2015)

Li, Y. ; Xia, Y.C. ; Han, M. ; Chen, G. ; Thasler, W.E. ; Luo, X. ; Protzer, U. ; Ning, Q.

IFN-α-mediated base excision repair pathway correlates with antiviral response against Hepatitis B Virus infection.

Hepatology 62, 1030A (2015)

Endig, J. ; Buitrago, L.E. ; Marhenke, S. ; Saborowski, A. ; Schuett, J. ; Reisinger, F. ; Limbourg, F. ; Koenecke, C. ; Schreder, A. ; Geffers, R. ; Manns, M.P. ; Heikenwälder, M. ; Longerich, T. ; Vogel, A.

CD8⁺ T-cells drive liver injury and hepatocellular carcinoma in chronic liver disease.

Hepatology 62, 1244A (2015)

Rebensburg, S.

Neue Ansätze zur Hemmung der HIV-Replikation.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2015, 146 S.

Schirmer, L. ; Wölfel, S. ; Georgi, E. ; Ploner, M. ; Bauer, B. ; Hemmer, B.

Extensive recruitment of plasma blasts to the cerebrospinal fluid in Toscana virus encephalitis.

Open Forum Infect. Dis. 2:ofv124 (2015)

Weber, J. ; Öllinger, R. ; Friedrich, M. ; Ehmer, U. ; Barenboim, M. ; Steiger, K. ; Heid, I.M. ; Mueller, S. ; Maresch, R. ; Engleitner, T. ; Gross, N. ; Geumann, U. ; Fu, B. ; Segler, A. ; Yuan, D.T. ; Lange, S. ; Strong, A. ; de la Rosa, J. ; Esposito, I. ; Liu, P. ; Cadiñanos, J. ; Vassiliou, G.S. ; Schmid, R.M. ; Schneider, G. ; Unger, K. ; Yang, F. ; Braren, R. ; Heikenwälder, M. ; Varela, I. ; Saur, D. ; Bradley, A. ; Rad, R.

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

Proc. Natl. Acad. Sci. U.S.A. 112, 13982-13987 (2015)

Reisinger, F.

Inflammation induced liver damage caused by viral infection or abberant metabolism.

München, Technische Universität, Fakultät für Medizin, Diss., 2015, 225 S.

Matheson, N.J. ; Sumner, J. ; Wals, K. ; Rapiteanu, R. ; Weekes, M.P. ; Vigan, R. ; Weinelt, J. ; Schindler, M. ; Antrobus, R. ; Costa, A.S.H. ; Frezza, C. ; Clish, C.B. ; Neil, S.J.D. ; Lehner, P.J.

Cell surface proteomic map of HIV infection reveals antagonism of amino acid metabolism by Vpu and Nef.

Cell Host Microbe 18, 409-423 (2015)

Dallaire, F. ; Schreiner, S. ; Blair, G.E. ; Dobner, T. ; Branton, P.E. ; Blanchette, P.

The human adenovirus type 5 E4orf6/E1B55K E3 ubiquitin ligase complex can mimic E1A effects on E2F.

mSphere 1:e00014-15 (2015)

Dallaire, F. ; Schreiner, S. ; Blair, G.E. ; Dobner, T. ; Branton, P.E. ; Blanchette, P.

The human adenovirus type 5 E4orf6/E1B55K E3 ubiquitin ligase complex enhances E1A functional activity.

mSphere 1:e00015-15 (2015)

Finkin, S. ; Yuan, D.T. ; Stein, I. ; Taniguchi, K. ; Weber, A. ; Unger, K. ; Browning, J.L. ; Goossens, N. ; Nakagawa, S. ; Gunasekaran, G. ; Schwartz, M.E. ; Kobayashi, M. ; Kumada, H. ; Berger, M. ; Pappo, O. ; Rajewsky, K. ; Hoshida, Y. ; Karin, M. ; Heikenwälder, M. ; Ben-Neriah, Y. ; Pikarsky, E.

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Nat. Immunol. 16, 1235-1244 (2015)

Ringelhan, M. ; Protzer, U.

Oncogenic potential of hepatitis B virus encoded proteins.

Curr. Opin. Virol. 14, 109-115 (2015)

Gondim, M.V. ; Wiltzer-Bach, L. ; Maurer, B. ; Banning, C. ; Arganaraz, E. ; Schindler, M.

AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in primary infected CD4+ T cells.

J. Virol. 89, 12518-12524 (2015)

Bürck, C. ; Mund, A. ; Berscheminski, J. ; Kieweg, L. ; Müncheberg, S. ; Dobner, T. ; Schreiner, S.

KAP1 is a host restriction factor that promotes HAdV E1B-55K SUMO modification.

J. Virol. 90, 930-946 (2015)

Bohne, F. ; Hasreiter, J. ; Quitt, O. ; Bockmann, J.H. ; Momburg, F. ; Protzer, U.

Bispecific antibody constructs mediate specific retargeting towards and elimination of hbv-positive hepatocytes and tumor cells.

J. Hepatol. 62, S555-S556 (2015)

Michler, T. ; Grosse, S.D. ; Mockenhaupt, S. ; Heikenwälder, M. ; Grimm, D. ; Protzer, U.

RNAi-based gene therapy for chronic hepatitis B: Evaluation in a murine model. L.

J. Hepatol. 62, S526 (2015)

Borst, K. ; Frenz, T. ; Spanier, J. ; Tegtmeyer, P. ; Chhatbar, C. ; Namineni, S. ; Lienenklaus, S. ; Köster, M. ; Heikenwälder, M. ; Sutter, G. ; Kalinke, U.

In virus-induced hepatitis local IFN-I responses modulate myeloid suppressor cell infiltration.

Cytokine 76, 108 (2015)

Seleznik, G.M. ; Seeger, H. ; Bauer, J. ; Fu, K. ; Czerkowicz, J. ; Papandile, A. ; Poreci, U. ; Rabah, D. ; Ranger, A. ; Cohen, C.D. ; Lindenmeyer, M. ; Chen, J. ; Edenhofer, I. ; Anders, H.J. ; Lech, M. ; Wüthrich, R.P. ; Ruddle, N.H. ; Moeller, M.J. ; Kozakowski, N. ; Regele, H. ; Browning, J.L. ; Heikenwälder, M. ; Segerer, S.

The lymphotoxin β receptor is a potential therapeutic target in renal inflammation.

Kidney Int. 89, 113–126 (2015)

Saito, Y. ; Ellegast, J.M. ; Kull, D. ; Heikenwälder, M. ; Flavell, R.A. ; Manz, M.G.

Development of human hemato-lymphoid system in human cytokine knock-in RAG2^-/-IL2RG^-/- mice engrafted with peripheral blood mobilized CD34⁺ cells.

Exp. Hematol. 43, S92 (2015)

Xia, Y. ; Stadler, D. ; Lucifora, J. ; Reisinger, F. ; Webb, D. ; Hösel, M. ; Michler, T. ; Wisskirchen, K. ; Cheng, X. ; Zhang, K. ; Chou, W.M. ; Wettengel, J.M. ; Malo, A. ; Bohne, F. ; Hoffmann, D. ; Eyer, F. ; Thimme, R. ; Falk, C.S. ; Thasler, W.E. ; Heikenwälder, M. ; Protzer, U.

Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis.

Gastroenterology 150, 194-205 (2015)

Mu, X. ; Español-Suñer, R. ; Mederacke, I. ; Affò, S. ; Manco, R. ; Sempoux, C. ; Lemaigre, F.P. ; Adili, A. ; Yuan, D.T. ; Weber, A. ; Unger, K. ; Heikenwälder, M. ; Leclercq, I.A. ; Schwabe, R.F.

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

J. Clin. Invest. 125, 3891-3903 (2015)

Becker, P.D. ; Nörder, M. ; Weissmann, S. ; Ljapoci, R. ; Erfle, V. ; Drexler, I. ; Guzman, C.A.

Gene expression driven by a strong viral promoter in MVA increases vaccination efficiency by enhancing antibody responses and unmasking CD8⁺ T cell epitopes.

Vaccines 2, 581-600 (2015)

Schmid, S.C. ; Thümer, L. ; Schuster, T. ; Horn, T. ; Kurtz, F. ; Slotta-Huspenina, J. ; Seebach, J. ; Straub, M. ; Maurer, T. ; Autenrieth, M. ; Kübler, H.R. ; Retz, M. ; Protzer, U. ; Gschwend, J.E. ; Hoffmann, D.

Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: A prospective translational study.

Infect. Agents Cancer 10:31 (2015)

Dargel, C.

T cell re-direction against glypican-3 for immunotherapy of hepatocellular carcinom.

München, Technische Universität, Fakultät für Medizin, Diss., 2015, 151 S.

Graf, S.

Role of the immunosuppressive environment during the course of a hepatitis B virus infection.

München, Technische Universität, Fakultät für Medizin, Diss., 2015, 145 S.

Hofmann, S.

The nuclear factor SPOC1 enhances HIV-1 integration but suppresses viral gene expression.

München, Technische Universität, Fakultät für Medizin, Diss., 2015, 91 S.

Wimmer, P. ; Schreiner, S.

Viral mimicry to usurp ubiquitin and sumo host pathways.

Viruses 7, 4854-4877 (2015)

Protzer, U.

Epigenetic control of HBV by HBx protein-releasing the break?

Nat. Rev. Gastroenterol. Hepatol. 12, 558-559 (2015)

Herranz, N. ; Gallage, S. ; Mellone, M. ; Wuestefeld, T. ; Klotz, S. ; Hanley, C.J. ; Raguz, S. ; Acosta, J.C. ; Innes, A.J. ; Banito, A. ; Georgilis, A. ; Montoya, A. ; Wolter, K. ; Dharmalingam, G. ; Faull, P. ; Carroll, T. ; Martínez-Barbera, J.P. ; Cutillas, P. ; Reisinger, F. ; Heikenwälder, M. ; Miller, R.A. ; Withers, D. ; Zender, L. ; Thomas, G.J. ; Gil, J.

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Nat. Cell Biol. 17, 1205-1217 (2015)

Cui, X. ; Luckenbaugh, L. ; Bruss, V. ; Hu, J.J.

Alteration of mature nucleocapsid and enhancement of covalently closed circular DNA formation by Hepatitis B Virus core mutants defective in complete virion formation.

J. Virol. 89, 10064-10072 (2015)

Bohne, F. ; Hasreiter, J. ; Quitt, O. ; Bockmann, J.H. ; Momburg, F. ; Protzer, U.

Bispecific antibody constructs mediate specific retargeting towards and elimination of HBV-positive hepatocytes and tumor cells.

J. Viral Hepat. 22, 8 (2015)

Weber, A. ; O'Connor, T. ; Heikenwälder, M.

Next generation of preclinical liver cancer models.

Clin. Cancer Res. 21, 4254-4256 (2015)

Orabi, A. ; Bieringer, M. ; Geerlof, A. ; Bruss, V.

An aptamer against the matrix binding domain on the hepatitis B virus capsid impairs virion formation.

J. Virol. 89, 9281-9287 (2015)

Gnirß, K. ; Zmora, P. ; Blazejewska, P. ; Winkler, M. ; Lins, A. ; Nehlmeier, I. ; Gärtner, S. ; Moldenhauer, A.S. ; Hofmann-Winkler, H. ; Wolff, T. ; Schindler, M. ; Pöhlmann, S.

Tetherin sensitivity of influenza A viruses is strain specific: Role of hemagglutinin and neuraminidase.

J. Virol. 89, 9178-9188 (2015)

Dargel, C. ; Bassani-Sternberg, M. ; Hasreiter, J. ; Zani, F. ; Bockmann, J.H. ; Thiele, F. ; Bohne, F. ; Wisskirchen, K. ; Wilde, S. ; Sprinzl, M.F. ; Schendel, D.J. ; Krackhardt, A.M. ; Uckert, W. ; Wohlleber, D. ; Schiemann, M. ; Stemmer, K. ; Heikenwälder, M. ; Busch, D.H. ; Richter, G. ; Mann, M. ; Protzer, U.

T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice.

Gastroenterology 149, 1042-1052 (2015)

Boutaffala, L. ; Bertrand, M.J. ; Remouchamps, C. ; Seleznik, G.M. ; Reisinger, F. ; Janas, M. ; Bénézech, C. ; Fernandes, M.T. ; Marchetti, S. ; Mair, F. ; Ganeff, C. ; Hupalowska, A. ; Ricci, J.E. ; Becher, B. ; Piette, J. ; Knolle, P. ; Caamano, J. ; Vandenabeele, P. ; Heikenwälder, M. ; Dejardin, E.

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis.

Cell Death Differ. 22, 2020-2033 (2015)

Schneider, M. ; Tigges, B. ; Meggendorfer, M. ; Helfer, M. ; Ziegenhain, C. ; Brack-Werner, R.

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain.

Aids 29, 1147-1159 (2015)

Graessel, A. ; Hauck, S.M. ; von Toerne, C. ; Kloppmann, E. ; Goldberg, T. ; Koppensteiner, H. ; Schindler, M. ; Knapp, B. ; Krause, L. ; Dietz, K. ; Schmidt-Weber, C.B. ; Suttner, K.

A combined omics approach to generate the surface atlas of human naive CD4⁺ T cells during early TCR activation.

Mol. Cell. Proteomics 14, 2085-2102 (2015)

Berger, E. ; Yuan, D.T. ; Waldschmitt, N. ; Rath, E. ; Allgaeuer, M. ; Staszewski, O. ; Kober, O. ; Lobner, E. ; Schoettl, T. ; Prinz, M. ; Weber, A. ; Gerhard, M. ; Klingenspor, M. ; Janssen, K.-. ; Heikenwälder, M. ; Haller, D.

Mitochondrial dysfunction impairs epithelial proliferative control and stemness in the intestinal crypts.

J. Crohns Colitis 9, S104 (2015)

Neff, F. ; Kirsch, D.G. ; Saur, D. ; Schmid, R.M. ; Heikenwälder, M. ; Siveke, J.T.

Notch triggers myeloid reprogramming in murine pancreatic cancer.

Eur. J. Cancer 51, S2 (2015)

Hoh, A. ; Heeg, M. ; Ni, Y. ; Schuch, A. ; Binder, B. ; Hennecke, N. ; Blum, H.E. ; Nassal, M. ; Protzer, U. ; Hofmann, M. ; Urban, S. ; Thimme, R.

HBV-infected HepG2^hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8⁺ T cells in vitro.

J. Virol. 89, 7433-7438 (2015)

Jors, S. ; Jeliazkova, P. ; Ringelhan, M. ; Thalhammer, J. ; Dürl, S. ; Ferrer, J. ; Sander, M. ; Heikenwälder, M. ; Schmid, R.M. ; Siveke, J.T. ; Geisler, F.

Lineage fate of ductular reactions in liver injury and carcinogenesis.

J. Clin. Invest. 125, 2445-2457 (2015)

Goldmann, T. ; Zeller, N. ; Raasch, J. ; Kierdorf, K. ; Frenzel, K. ; Ketscher, L. ; Basters, A. ; Staszewski, O. ; Brendecke, S.M. ; Spiess, A. ; Tay, T.L. ; Kreutz, C. ; Timmer, J. ; Mancini, G.M. ; Blank, T. ; Fritz, G. ; Biber, K. ; Lang, R. ; Malo, D. ; Merkler, D. ; Heikenwälder, M. ; Knobeloch, K.P. ; Prinz, M.

USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

EMBO J. 34, 1612-1629 (2015)

Vincendeau, M. ; Göttesdorfer, I. ; Schreml, J. ; Wetie, A. ; Mayer, J. ; Greenwood, A.D. ; Helfer, M. ; Kramer, S. ; Seifarth, W. ; Hadian, K. ; Brack-Werner, R. ; Leib-Mösch, C.

Modulation of Human Endogenous Retrovirus (HERV) transcription during persistent and de novo HIV-1 infection.

Retrovirol. 12:27 (2015)

Vassena, L. ; Giuliani, E. ; Koppensteiner, H. ; Bolduan, S. ; Schindler, M. ; Doria, M.

HIV-1 NEF and VPU interfere with L-selectin (CD62L) cell surface expression to inhibit adhesion and signaling in infected CD4⁺ t lymphocytes.

J. Virol. 89, 5687-5700 (2015)

O'Connor, T. ; Borsig, L. ; Heikenwälder, M.

CCL2-CCR2 signaling in disease pathogenesis.

Endocr. Metab. Immune Disord. Drug Targets 15, 105-118 (2015)

Jacobi, C. ; Ayx, I. ; Fritsche, K. ; Piontek, G. ; Hoffmann, D. ; Weirich, G. ; Knopf, A.

Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck.

Oncotarget 6, 3462-3470 (2015)

Loffredo-Verde, E. ; Abdel-Aziz, I.Z. ; Albrecht, J. ; El Guindy, N.M. ; Yacob, M. ; Solieman, A.S. ; Protzer, U. ; Busch, D.H. ; Layland, L.E. ; Prazeres da Costa, C.U.

Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype.

Parasite Immunol. 37, 97-104 (2015)

Lambelé, M. ; Koppensteiner, H. ; Symeonides, M. ; Roy, N.H. ; Chan, J. ; Schindler, M. ; Thali, M.

Vpu is the main determinant for tetraspanin downregulation in HIV-1 infected cells.

J. Virol. 89, 3247-3255 (2015)

Dembek, C.J. ; Protzer, U.

Mouse models for therapeutic vaccination against hepatitis B virus.

Med. Microbiol. Immunol. 204, 95-102 (2015)

Thiele, F. ; Tao, S. ; Zhang, Y. ; Muschaweckh, A. ; Zollmann, T. ; Protzer, U. ; Abele, R. ; Drexler, I.

MVA-infected dendritic cells present CD4⁺ T-cell epitopes by endogenous MHC class II presentation pathways.

J. Virol. 98, 2698-2709 (2015)

Sprinzl, M.F. ; Puschnik, A. ; Schlitter, A.M. ; Schad, A. ; Ackermann, K. ; Esposito, I. ; Lang, H. ; Galle, P.R. ; Weinmann, A. ; Heikenwälder, M. ; Protzer, U.

Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.

J. Hepatol. 62, 863-870 (2015)

Protzer, U. ; Böhm, F. ; Longerich, T. ; Seebach, J. ; Heidary Navid, M. ; Friemel, J. ; Marques-Maggio, E. ; Bawohl, M. ; Heikenwälder, M. ; Schirmacher, P. ; Dutkowski, P. ; Clavien, P.A. ; Schemmer, P. ; Schnitzler, P. ; Gotthardt, D. ; Müllhaupt, B. ; Weber, A.

Molecular detection of Hepatitis E Virus (HEV) in liver biopsies after liver transplantation.

Mod. Pathol. 28, 523-532 (2015)

Seubert, B. ; Cui, H. ; Simonavicius, N. ; Honert, K. ; Schafer, S. ; Reuning, U. ; Heikenwälder, M. ; Mari, B. ; Krüger, A.

Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization.

Int. J. Cancer 136, 2304-2315 (2015)

Friemel, J. ; Rechsteiner, M.P. ; Frick, L. ; Boehm, F. ; Struckmann, K. ; Sigg, M. ; Moch, H. ; Heikenwälder, M. ; Weber, A.

Intratumor heterogeneity in hepatocellular carcinoma.

Clin. Cancer Res. 21, 1951-1961 (2015)

Ringelhan, M. ; Protzer, U. ; O'Connor, T. ; Heikenwälder, M.

The direct and indirect role of HBV in liver cancer: Prospective markers for HCC-screening and potential therapeutic targets.

J. Pathol. 235, 355-367 (2015)

Seubert, B. ; Grünwald, B. ; Kobuch, J. ; Cui, H. ; Schelter, F. ; Schaten, S. ; Siveke, J.T. ; Lim, N.H. ; Nagase, H. ; Simonavicius, N. ; Heikenwälder, M. ; Reinheckel, T. ; Sleeman, J.P. ; Janssen, K.P. ; Knolle, P.A. ; Krüger, A.

TIMP-1 creates a pre-metastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Hepatology 61, 238-248 (2015)

Bergmann, H.

Card9 signaling in the innate immune system drives carcinogenesis in the colon under inflammatory conditions.

München, Technische Universität, Fakultät für Medizin, Diss., 2014, 116 S.

Ringelhan, M. ; Reisinger, F. ; Yuan, D.T. ; Weber, A. ; Heikenwälder, M.

Modeling human liver cancer heterogeneity: Virally induced transgenic models and mouse genetic models of chronic liver inflammation.

Curr. Protoc. Pharmacol. 67, 14.31.1-14.31.17 (2014)

Höhne, K.

HIV-1 Vpr stimuliert NFAT zur Induktion der LTR-Transaktivierung und frühen T-Zellaktivierung.

München, Technische Universität, Fakultät für Medizin, Diss., 2014, 130 S.

Mohr, C.

Influence of hepatitis B virus surface protein variants associated with antiviral resistance on viral assembly and secretion of hepatitis B and hepatitis D viruses.

Gießen, Justus-Liebig-Universität, Fakultät für Biologie und Chemie, Diss., 2014, 115 S.

Bauer, J. ; Sandhöfer, N. ; Hiddemann, W. ; Spiekermann, K.

Novel FLT3 mutation shows dominant negative effects on the wild-type FLT3 receptor.

Eur. J. Cancer 50, S121 (2014)

Simonavicius, N. ; Seubert, B. ; Borsig, L. ; Wohlleber, D. ; Browning, J. ; Krueger, A. ; Heikenwälder, M.

Lymphotoxin signalling alters the vasculature to increase tumour cell metastasis.

Eur. J. Cancer 50, S88 (2014)

Böttinger, N.

Adoptive immunotherapy for treatment of chronic hepatitis B.

München, Technische Universität, Fakultät für Medizin, Diss., 2014, 142 S.

Graf, J.

Mechanismen der Insulin Resistenz bei chronischer HCV-Infektion.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 147 S.

Wieduwild, R. ; Lin, W. ; Boden, A. ; Kretschmer, K. ; Zhang, Y.

A repertoire of peptide tags for controlled drug release from injectable noncovalent hydrogel.

Biomacromolecules 15, 2058-2066 (2014)

Seleznik, G.M. ; Reding, T. ; Sonda, S. ; Heikenwälder, M. ; Graf, R.

Lymphotoxin promotes acinar cell reprogramming and accelerates pre-neoplastic conversion in Kras induced pancreatic tumorigenesis.

Pancreas 43, 1406 (2014)

Yabal, M. ; Müller, N. ; Adler, H. ; Knies, N. ; Gross, C.J. ; Damgaard, R.B. ; Kanegane, H. ; Ringelhan, M. ; Kaufmann, T. ; Heikenwälder, M. ; Strasser, A. ; Gross, O. ; Ruland, J. ; Peschel, C. ; Gyrd-Hansen, M. ; Jost, P.J.

Aberrant TNF signalling in dendritic cells in the absence of XIAP contributes to X-linked lymphoproliferative disease (XLP-2) by exaggerated necroptosis.

Oncol. Res. Treat. 37, 246 (2014)

Gewies, A. ; Gorka, O. ; Bergmann, H. ; Pechloff, K. ; Petermann, F. ; Jeltsch, K. ; Rudelius, M. ; Kriegsmann, M. ; Weichert, W. ; Horsch, M. ; Beckers, J. ; Wurst, W. ; Heikenwälder, M. ; Korn, T. ; Heissmeyer, V. ; Ruland, J.

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Cell Rep. 9, 1292-1305 (2014)

Wolf, M.J. ; Adili, A. ; Piotrowitz, K. ; Abdullah, Z. ; Boege, Y. ; Stemmer, K. ; Ringelhan, M. ; Simonavicius, N. ; Egger, M. ; Wohlleber, D. ; Lorentzen, A.R. ; Einer, C. ; Schulz, S. ; Clavel, T. ; Protzer, U. ; Thiele, C. ; Zischka, H. ; Moch, H. ; Tschöp, M.H. ; Tumanov, A.V. ; Haller, D. ; Unger, K. ; Karin, M. ; Kopf, M. ; Knolle, P. ; Weber, A. ; Heikenwälder, M.

Metabolic activation of intrahepatic CD8⁺ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.

Cancer Cell 26, 549-564 (2014)

Jeltsch, K. ; Hu, D. ; Brenner, S. ; Zöller, J. ; Heinz, G.A. ; Nagel, D. ; Vogel, K.U. ; Rehage, N. ; Warth, S.C. ; Edelmann, S.L. ; Gloury, R. ; Martin, N. ; Lohs, C. ; Lech, M. ; Stehklein, J.E. ; Geerlof, A. ; Kremmer, E. ; Weber, A. ; Anders, H.J. ; Schmitz, I. ; Schmidt-Supprian, M. ; Fu, M. ; Holtmann, H. ; Krappmann, D. ; Ruland, J. ; Kallies, A. ; Heikenwälder, M. ; Heissmeyer, V.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T_H17 differentiation.

Nat. Immunol. 15, 1079-1089 (2014)

Schölzel, K. ; Schildberg, F.A. ; Welz, M. ; Borner, C. ; Geiger, S. ; Kurts, C. ; Heikenwälder, M. ; Knolle, P.A. ; Wohlleber, D.

Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance.

J. Hepatol. 61, 600-608 (2014)

Bayer, K.

Characterization of fluorescently-labeled hepatitis C virus genomes and their application to visualize the intracellular transport of viral particles.

München, Technische Universität, Fakultät für Medizin, Diss., 2014, 112 S.

Gautheron, J. ; Vucur, M. ; Reisinger, F. ; Cardenas, D.V. ; Roderburg, C. ; Koppe, C. ; Kreggenwinkel, K. ; Schneider, A.T. ; Bartneck, M. ; Neumann, U.P. ; Canbay, A. ; Reeves, H.L. ; Luedde, M. ; Tacke, F. ; Trautwein, C. ; Heikenwälder, M. ; Luedde, T.

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.

EMBO Mol. Med. 6, 1062-1074 (2014)

Lucifora, J. ; Xia, Y. ; Reisinger, F. ; Stadler, D. ; Heikenwälder, M. ; Protzer, U.

Dégradation spécifique de l´ADN nucléaire responsable de la persistance du virus de l´hépatite B.

Med. Sci. (Paris) 30, 724-726 (2014)

Unger, K. ; Heikenwälder, M.

Analysis of chromosomal aberrations in murine HCC.

Methods Mol. Biol. 1193, 213-226 (2014)

Kremb, S. ; Helfer, M. ; Kraus, B. ; Wolff, H. ; Wild, C. ; Schneider, M. ; Voolstra, C.R. ; Brack-Werner, R.

Aqueous extracts of the marine brown alga Lobophora variegata inhibit HIV-1 infection at the level of virus entry into cells.

PLoS ONE 9:e103895 (2014)

Protzer, U.

Cure of HBV infection: Can APOBEC3 deaminases mediate it?

JAIDS 65, 53 (2014)

Nehls, J. ; Koppensteiner, H. ; Brack-Werner, R. ; Floß, T. ; Schindler, M.

HIV-1 replication in human immune cells is independent of TAR DNA binding Protein 43 (TDP-43) expression.

PLoS ONE 9:e105478 (2014)

Bolduan, S. ; Reif, T. ; Schindler, M. ; Schubert, U.

HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain.

Virology 464-465, 375-384 (2014)

Wisskirchen, K. ; Lucifora, J. ; Michler, T. ; Protzer, U.

New pharmacological strategies to fight enveloped viruses.

Trends Pharmacol. Sci. 35, 470-478 (2014)

Eisele, Y.S. ; Fritschi, S.K. ; Hamaguchi, T. ; Obermüller, U. ; Füger, P. ; Skodras, A. ; Schäfer, C. ; Odenthal, J. ; Heikenwälder, M. ; Staufenbiel, M. ; Jucker, M.

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

J. Neurosci. 34, 10264-10273 (2014)

Voith von Voithenberg, L. ; Sanchez-Rico, C. ; Warner, L. ; Zhang, Y. ; Sattler, M. ; Lamb, D.C.

Conformational dynamics during spliceosome assembly investigated by single-pair FRET.

Biophys. J. 106, 465A (2014)

Boettcher, S. ; Gerosa, R. ; Radpour, R. ; Bauer, J. ; Ampenberger, F. ; Heikenwälder, M. ; Kopf, M. ; Manz, M.G.

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.

Blood 124, 1393-1403 (2014)

Bohne, F. ; Londoño, M.C. ; Benítez, C. ; Miquel, R. ; Martínez-Llordella, M. ; Russo, C. ; Ortiz, C. ; Bonaccorsi-Riani, E. ; Brander, C. ; Bauer, T. ; Protzer, U. ; Jaeckel, E. ; Taubert, R. ; Forns, X. ; Navasa, M. ; Berenguer, M. ; Rimola, A. ; Lozano, J.J. ; Sánchez-Fueyo, A.

HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans.

Sci. Transl. Med. 6:242ra81 (2014)

Schittl, B. ; Bruss, V.

Mutational profiling of the variability of individual amino acid positions in the hepatitis B virus matrix domain.

Virology 458-459, 183-189 (2014)

Xia, Y. ; Lucifora, J. ; Reisinger, F. ; Heikenwälder, M. ; Protzer, U.

Response to comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".

Science 344:1237 (2014)

Yabal, M. ; Müller, N. ; Adler, H. ; Knies, N. ; Groß, C.J. ; Damgaard, R.B. ; Kanegane, H. ; Ringelhan, M. ; Kaufmann, T. ; Heikenwälder, M. ; Strasser, A. ; Groß, O. ; Ruland, J. ; Peschel, C. ; Gyrd-Hansen, M. ; Jost, P.J.

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.

Cell Rep. 7, 1796-1808 (2014)

Waldschmitt, N. ; Berger, E. ; Rath, E. ; Sartor, R.B. ; Weigmann, B. ; Heikenwälder, M. ; Gerhard, M. ; Janssen, K.P. ; Haller, D.

C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation.

Mucosal Immunol. 7, 1452-1466 (2014)

Zhang, Y.

Characterization of endogenous major histocompatibility complex class II antigen processing pathways for modified vaccinia virus Ankara infection.

München, Technische Universität, Fakultät für Medizin, Diss., 2014, 135 S.

Hagen, N. ; Bayer, K. ; Roesch, K. ; Schindler, M.

The intra viral protein interaction network of hepatitis C virus.

Mol. Cell. Proteomics 13, 1676-1689 (2014)

Wuestenberg, A. ; Kah, J. ; Singethan, K. ; Sirma, H. ; Keller, A.D. ; Rosal, S.R. ; Schrader, J. ; Loscher, C. ; Volz, T. ; Bartenschlager, R. ; Lohmann, V. ; Protzer, U. ; Dandri, M. ; Lohse, A.W. ; Tiegs, G. ; Sass, G.

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

PLoS ONE 9:e96533 (2014)

Krebs, K.M. ; Böttinger, N. ; Huang, L. ; Chmielewski, M. ; Uckert, W. ; Abken, H. ; Heikenwälder, M. ; Knolle, P. ; Protzer, U.

T cells redirected by a chimeric antigen receptor recognizing HBSAG efficiently control hbv in vivo in transgenic mice.

Cytotherapy 16, S9 (2014)

Roth, S. ; Rottach, A. ; Lotz-Havla, A.S. ; Laux, V. ; Muschaweckh, A. ; Gersting, S.W. ; Muntau, A.C. ; Hopfner, K.P. ; Jin, L. ; Vanness, K. ; Petrini, J.H. ; Drexler, I. ; Leonhardt, H. ; Ruland, J.

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

Nat. Immunol. 15, 538-545 (2014)

Gnirß, K. ; Fiedler, M. ; Krämer-Kühl, A. ; Bolduan, S. ; Mittler, E. ; Becker, S. ; Schindler, M. ; Pöhlmann, S.

Analysis of determinants in filovirus glycoproteins required for tetherin antagonism.

Viruses 6, 1654-1671 (2014)

Franceschi, V. ; Stellari, F.F. ; Mangia, C. ; Jacca, S. ; Lavrentiadou, S. ; Cavirani, S. ; Heikenwälder, M. ; Donofrio, G.

In vivo image analysis of BoHV-4-based vector in mice.

PLoS ONE 9:e95779 (2014)

Heikenwälder, M. ; Protzer, U.

LINE(1)s of evidence in HBV-driven liver cancer.

Cell Host Microbe 15, 249-250 (2014)

Rothhammer, V. ; Muschaweckh, A. ; Gasteiger, G. ; Petermann, F. ; Heink, S. ; Busch, D. ; Heikenwälder, M. ; Hemmer, B. ; Drexler, I. ; Korn, T.

α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.

Acta Neuropathol. Commun. 2:27 (2014)

Lucifora, J. ; Xia, Y. ; Reisinger, F. ; Zhang, K. ; Stadler, D. ; Cheng, X. ; Sprinzl, M.F. ; Koppensteiner, H. ; Makowska, Z. ; Volz, T. ; Remouchamps, C. ; Chou, W.-M. ; Thasler, W.E. ; Hüser, N. ; Durantel, D. ; Liang, T.J. ; Münk, C. ; Heim, M.H. ; Browning, J.L. ; Dejardin, E. ; Dandri, M. ; Schindler, M. ; Heikenwälder, M. ; Protzer, U.

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Science 343, 1221-1228 (2014)

Seleznik, G.M. ; Zöller, J. ; O'Connor, T. ; Graf, R. ; Heikenwälder, M.

The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.

Cytokine Growth Factor Rev. 25, 125-137 (2014)

Hösel, M. ; Lucifora, J. ; Michler, T. ; Holz, G. ; Gruffaz, M. ; Stahnke, S. ; Zoulim, F. ; Durantel, D. ; Heikenwälder, M. ; Nierhoff, D. ; Millet, R. ; Salvetti, A. ; Protzer, U. ; Buning, H.

Hepatitis B virus infection enhances susceptibility towards adeno-associated viral vector transduction in vitro and in vivo.

Hepatology 59, 2110-2120 (2014)

Helfer, M. ; Koppensteiner, H. ; Schneider, M. ; Rebensburg, S. ; Forcisi, S. ; Müller, C. ; Schmitt-Kopplin, P. ; Schindler, M. ; Brack-Werner, R.

The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor.

PLoS ONE 9:e87487 (2014)

Wyler, L. ; Napoli, C.U. ; Ingold, B. ; Sulser, T. ; Heikenwälder, M. ; Schraml, P. ; Moch, H.

Brain metastasis in renal cancer patients: Metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.

Br. J. Cancer 110, 686-694 (2014)

Koppensteiner, H. ; Höhne, K. ; Gondim, M.V. ; Gobert, F.-X. ; Widder, M. ; Gundlach, S. ; Heigele, A. ; Kirchhoff, F. ; Winkler, M. ; Benaroch, P. ; Schindler, M.

Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.

Retrovirol. 11:1 (2014)

Golsaz Shirazi, F. ; Mohammadi, H. ; Amiri, M.M. ; Singethan, K. ; Xia, Y. ; Bayat, A.A. ; Bahadori, M. ; Rabbani, H. ; Jeddi-Tehrani, M. ; Protzer, U. ; Shokri, F.

Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV infection.

J. Gastroenterol. Hepatol. 29, 1083-1091 (2014)

Sprinzl, M.F. ; Russo, C. ; Kittner, J. ; Allgayer, S. ; Grambihler, A. ; Bartsch, B. ; Weinmann, A. ; Galle, P.R. ; Schuchmann, M. ; Protzer, U. ; Bauer, T.

Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment.

J. Viral Hepat. 21, 633-641 (2014)

Xia, Y.

Effector pathway of the antiviral effect of interferons in Hepatitis B Virus infection.

München, Technische Universität, Fakultät für Medizin, Diss., 2013, 151 S.

Xia, Y. ; Lucifora, J. ; Zhang, K. ; Cheng, X. ; Stadler, D. ; Reisinger, F. ; Feuerherd, M. ; Makowska, Z. ; Hartmann, D. ; Thasler, W.E. ; Heim, M.H. ; Heikenwälder, M. ; Protzer, U.

Interferons induce degradation of HBV CccDNA.

Hepatology 58, 274A-275A (2013)

van Nuffel, A. ; Ariën, K.K. ; Stove, V. ; Schindler, M. ; O'Neill, E. ; Schmökel, J. ; van de Walle, I. ; Naessens, E. ; Vanderstraeten, H. ; van Landeghem, K. ; Taghon, T. ; Pulkkinen, K. ; Saksela, K. ; Garcia, J.V. ; Fackler, O.T. ; Kirchhoff, F. ; Verhasselt, B.

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.

Retrovirol. 10:137 (2013)

Czogalla, A. ; Petrov, E.P. ; Kauert, D.J. ; Uzunova, V. ; Zhang, Y. ; Seidel, R. ; Schwille, P.

Switchable domain partitioning and diffusion of DNA origami rods on membranes.

Faraday Discuss. 161, 31-43 (2013)

Kruglov, A.A. ; Grivennikov, S.I. ; Kuprash, D.V. ; Winsauer, C. ; Prepens, S. ; Seleznik, G.M. ; Eberl, G. ; Littman, D.R. ; Heikenwälder, M. ; Tumanov, A.V. ; Nedospasov, S.A.

Nonredundant function of soluble LTα₃ produced by innate lymphoid cells in intestinal homeostasis.

Science 342, 1243-1246 (2013)

Xia, Y. ; Lucifora, J. ; Zhang, K. ; Cheng, X. ; Reisinger, F. ; Feuerherd, M. ; Heikenwälder, M. ; Protzer, U.

Interferon-alpha eliminates HBV cccDNA via base excision repair pathway.

J. Hepatol. 58, S57 (2013)

Orabi, A.

In vitro selection and characterization of single stranded DNA aptamers inhibiting the hepatitis B virus capsid-envelope interaction.

München, Ludwig-Maximilians-Universität, Tierärztliche Fakultät, Diss., 2013, 115 S.

Goldmann, T. ; Wieghofer, P. ; Müller, P.F. ; Wolf, Y. ; Varol, D. ; Yona, S. ; Brendecke, S.M. ; Kierdorf, K. ; Staszewski, O. ; Datta, M. ; Luedde, T. ; Heikenwälder, M. ; Jung, S. ; Prinz, M.

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.

Nat. Neurosci. 16, 1618-1626 (2013)

Borsig, L. ; Wolf, M.J. ; Roblek, M. ; Lorentzen, A.R. ; Heikenwälder, M.

Inflammatory chemokines and metastasis - tracing the accessory.

Oncogene 33, 3217-3224 (2013)

Assinger, A. ; Yaiw, K.C. ; Göttesdorfer, I. ; Leib-Mösch, C. ; Söderberg-Nauclér, C.

Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription.

Retrovirol. 10:132 (2013)

Felmy, B. ; Songhet, P. ; Slack, E.M. ; Müller, A.J. ; Kremer, M. ; van Maele, L. ; Cayet, D. ; Heikenwälder, M. ; Sirard, J.C. ; Hardt, W.D.

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella typhimurium.

PLoS ONE 8:e77204 (2013)

Kutscher, S. ; Dembek, C.J. ; Deckert, S. ; Russo, C. ; Körber, N. ; Bogner, J.R. ; Geisler, F. ; Umgelter, A. ; Neuenhahn, M. ; Albrecht, J. ; Cosma, A. ; Protzer, U. ; Bauer, T.

Overnight resting of PBMC changes functional signatures of antigen specific T-cell responses: Impact for immune monitoring within clinical trials.

PLoS ONE 8:e76215 (2013)

Maliniemi, P. ; Vincendeau, M. ; Mayer, J. ; Frank, O. ; Hahtola, S. ; Karenko, L. ; Carlsson, E. ; Mallet, F. ; Seifarth, W. ; Leib-Mösch, C. ; Ranki, A.

Expression of human endogenous retrovirus-W including syncytin-1 in cutaneous T-cell lymphoma.

PLoS ONE 8:e76281 (2013)

Hoffmann, D. ; Mauroy, A. ; Seebach, J. ; Simon, V. ; Wantia, N. ; Protzer, U.

New norovirus classified as a recombinant GII.g/GII.1 causes an extended foodborne outbreak at a university hospital in Munich.

J. Clin. Virol. 58, 24-30 (2013)

Willimsky, G. ; Protzer, U. ; Knolle, P. ; Heikenwälder, M.

Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?

Oncotarget 4, 1117-1118 (2013)

Vucur, M. ; Reisinger, F. ; Gautheron, J. ; Janssen, J. ; Roderburg, C. ; Cardenas, D.V. ; Kreggenwinkel, K. ; Koppe, C. ; Hammerich, L. ; Hakem, R. ; Unger, K. ; Weber, A. ; Gassler, N. ; Luedde, M. ; Frey, N. ; Neumann, U.P. ; Tacke, F. ; Trautwein, C. ; Heikenwälder, M. ; Luedde, T.

RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation.

Cell Rep. 4, 776-790 (2013)

Gaudin, R. ; Bèrre, S. ; Cunha de Alencar, B. ; Decalf, J. ; Schindler, M. ; Gobert, F.X. ; Jouve, M. ; Benaroch, P.

Dynamics of HIV-containing compartments in macrophages reveal sequestration of virions and transient surface connections.

PLoS ONE 8:e69450 (2013)

Manic, G. ; Maurin-Marlin, A. ; Laurent, F. ; Vitale, I. ; Thierry, S. ; Delelis, O. ; Dessen, P. ; Vincendeau, M. ; Leib-Mösch, C. ; Hazan, U. ; Mouscadet, J.F. ; Bury-Moné, S.

Impact of the Ku complex on HIV-1 expression and latency.

PLoS ONE 8:e69691 (2013)

Ringelhan, M. ; Heikenwälder, M. ; Protzer, U.

Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development.

Dig. Dis. 31, 138-151 (2013)

Ludwig, T. ; Worsch, S. ; Heikenwälder, M. ; Daniel, H. ; Hauner, H. ; Bader, B.L.

Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice.

Am. J. Physiol. Endocrinol. Metab. 304, E1140-E1156 (2013)

Vincendeau, M. ; Nagel, D. ; Brenke, J.K. ; Brack-Werner, R. ; Hadian, K.

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts.

Virol. J. 10:151 (2013)

Bolduan, S. ; Hubel, P. ; Reif, T. ; Lodermeyer, V. ; Höhne, K. ; Fritz, J.V. ; Sauter, D. ; Kirchhoff, F. ; Fackler, O.T. ; Schindler, M. ; Schubert, U.

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

Virology 440, 190-203 (2013)

Krebs, K.M. ; Böttinger, N. ; Huang, L.R. ; Chmielewski, M. ; Arzberger, S. ; Gasteiger, G. ; Jager, C. ; Schmitt, E. ; Bohne, F. ; Aichler, M. ; Uckert, W. ; Abken, H. ; Heikenwälder, M. ; Knolle, P. ; Protzer, U.

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

Gastroenterology 145, 456-465 (2013)

Huang, L.R. ; Wohlleber, D. ; Reisinger, F. ; Jenne, C.N. ; Cheng, R.L. ; Abdullah, Z. ; Schildberg, F.A. ; Odenthal, M. ; Dienes, H.P. ; van Rooijen, N. ; Schmitt, E. ; Garbi, N. ; Croft, M. ; Kurts, C. ; Kubes, P. ; Protzer, U. ; Heikenwälder, M. ; Knolle, P.A.

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8⁺ T cells and successful immunotherapy against chronic viral liver infection.

Nat. Immunol. 14, 574-583 (2013)

Sprinzl, M.F. ; Reisinger, F. ; Puschnik, A. ; Ringelhan, M. ; Ackermann, K. ; Hartmann, D. ; Schiemann, M. ; Weinmann, A. ; Galle, P.R. ; Schuchmann, M. ; Friess, H. ; Otto, G. ; Heikenwälder, M. ; Protzer, U.

Sorafenib perpetuates cellular anti-cancer effector functions by modulating the cross talk between macrophages and natural killer cells.

Hepatology 57, 2358-2368 (2013)

Benhenda, S. ; Ducroux, A. ; Rivière, L. ; Sobhian, B. ; Ward, M.D. ; Dion, S. ; Hantz, O. ; Protzer, U. ; Michel, M.L. ; Benkirane, M. ; Semmes, O.J. ; Buendia, M.A. ; Neuveut, C.

Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of Hepatitis B Virus transcription.

J. Virol. 87, 4360-4371 (2013)

Vogel, K.U. ; Edelmann, S.L. ; Jeltsch, K. ; Bertossi, A. ; Heger, K. ; Heinz, G.A. ; Zöller, J. ; Warth, S.C. ; Hoefig, K.P. ; Lohs, C. ; Neff, F. ; Kremmer, E. ; Schick, J. ; Repsilber, D. ; Geerlof, A. ; Blum, H. ; Wurst, W. ; Heikenwälder, M. ; Schmidt-Supprian, M. ; Heissmeyer, V.

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Immunity 38, 655-668 (2013)

Kierdorf, K. ; Erny, D. ; Goldmann, T. ; Sander, V. ; Schulz, C. ; Perdiguero, E.G. ; Wieghofer, P. ; Heinrich, A. ; Riemke, P. ; Hölscher, C. ; Müller, D.N. ; Luckow, B. ; Brocker, T. ; Debowski, K. ; Fritz, G. ; Opdenakker, G. ; Diefenbach, A. ; Biber, K. ; Heikenwälder, M. ; Geissmann, F. ; Rosenbauer, F. ; Prinz, M.

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.

Nat. Neurosci. 16, 273-280 (2013)

Buchmann, P. ; Dembek, C.J. ; Kuklick, L. ; Jager, C. ; Tedjokusumo, R. ; von Freyend, M.J. ; Drebber, U. ; Janowicz, Z. ; Melber, K. ; Protzer, U.

A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in Hepatitis B Virus (HBV) transgenic mice.

Vaccine 31, 1197-1203 (2013)

Heikenwälder, M. ; Borsig, L.

Pathways of metastasizing intestinal cancer cells revealed: How will fighting metastases at the site of cancer cell arrest affect drug development?

Future Oncol. 9, 1-4 (2013)

Guenounou, S. ; Bosquet, N. ; Dembek, C.J. ; Le Grand, R. ; Cosma, A.

OMIP-016: Characterization of antigen-responsive macaque and human T-cells.

Cytometry A 83, 182-184 (2013)

Siegler, V.D. ; Bruß, V.

Role of transmembrane domains of hepatitis B virus small surface proteins in subviral-particle biogenesis.

J. Virol. 87, 1491-1496 (2013)

Lucifora, J. ; Esser, K. ; Protzer, U.

Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes.

Antiviral Res. 97, 195-197 (2013)

Tao, S.

Evaluation of new early detection markers for gastrointestinal tumors : Perspectives for detection of colorectal cancer based on immunological fecal occult blood tests and blood-based markers.

Heidelberg, Universität, Diss., 2012, 105 S.

Esser, K.

Das Hepatitis B Virus folgt dem Transport der neutralen Lipide in die Leber und in die Hepatozyten, um seine Wirtszelle zu erreichen und zu infizieren.

Köln, Universität, Medizinische und Mathematisch-Naturwissenschaftliche Fakultät, Diss., 2012, 176 S.

Scisciani, C. ; Pediconi, N. ; Lucifora, J. ; Guerrieri, F. ; Rose-John, S. ; Protzer, U. ; Levrero, M. ; Belloni, L.

OC-9 IL6, IL6-induced miRNAs and HNF1α/HNF4α in the epigenetic control of cccDNA transcription.

Dig. Liver Dis. 44, S4 (2012)

Leib-Mösch, C. ; Diem, O.

Endogene Retroviren und Schizophrenie.

Retrovirus-Bull. 4, 4-6 (2012)

Schittl, B.

Characterization of the hepatitis B virus matrix domain function in virion assembly.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2012, 103 S.

Krebs, K.M.

Adoptive T-Zelltherapie der chronischen Hepatitis B.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2012, 147 S.

Nauerth, M.

Development of a novel TCR avidity assay for human CD8⁺ T cells.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2012, 125 S.

Broxtermann, M.

Die Erkennung viraler Partikel durch Rezeptoren des angeborenen Immunsystems am Beispiel des HBV und AAV.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2012, 157 S.

Hoffmann, D. ; Schwarck, D. ; Banning, C. ; Brenner, M. ; Mariyanna, L. ; Krepstakies, M. ; Schindler, M. ; Millar, D.P. ; Hauber, J.

Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.

PLoS ONE 7:e38305 (2012)

O'Connor, T. ; Frei, N. ; Sponarova, J. ; Schwarz, P. ; Heikenwälder, M. ; Aguzzi, A.

Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes.

PLoS Pathog. 8:e1002867 (2012)

Krautler, N.J. ; Kana, V. ; Kranich, J. ; Tian, Y. ; Perera, D. ; Lemm, D. ; Schwarz, P. ; Armulik, A. ; Browning, J.L. ; Tallquist, M. ; Buch, T. ; Oliveira-Martins, J.B. ; Zhu, C. ; Hermann, M. ; Wagner, U. ; Brink, R. ; Heikenwälder, M. ; Aguzzi, A.

Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Cell 150, 194-206 (2012)

Braeckman, T. ; van Herck, K. ; Jilg, W. ; Bauer, T. ; van Damme, P.

Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

Vaccine 30, 4757-4761 (2012)

Zhang, D. ; Dong, P. ; Zhang, K. ; Deng, L. ; Bach, C. ; Chen, W. ; Li, F. ; Protzer, U. ; Ding, H. ; Zeng, C.

Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.

BMC Microbiol. 12:307 (2012)

Gosenca, D. ; Gabriel, U. ; Steidler, A. ; Mayer, J. ; Diem, O. ; Erben, P. ; Fabarius, A. ; Leib-Mösch, C. ; Hofmann, W.-K. ; Seifarth, W.

HERV-E-mediated modulation of PLA2G4A transcription in urothelial carcinoma.

PLoS ONE 7:e49341 (2012)

Seleznik, G.M. ; Reding, T. ; Romrig, F. ; Saito, Y. ; Mildner, A. ; Segerer, S. ; Sun, L.K. ; Regenass, S. ; Lech, M. ; Anders, H.J. ; McHugh, D. ; Kumagi, T. ; Hiasa, Y. ; Lackner, C. ; Haybaeck, J. ; Angst, E. ; Perren, A. ; Balmer, M.L. ; Slack, E. ; Macpherson, A. ; Manz, M.G. ; Weber, A. ; Browning, J.L. ; Arkan, M.C. ; Rülicke, T. ; Aguzzi, A. ; Prinz, M. ; Graf, R. ; Heikenwälder, M.

Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis.

Gastroenterology 143, 1361-1374 (2012)

Chew, V. ; Tow, C. ; Huang, C. ; Bard-Chapeau, E. ; Copeland, N.G. ; Jenkins, N.A. ; Weber, A. ; Lim, K.H. ; Toh, H.C. ; Heikenwälder, M. ; Ng, I.O. ; Nardin, A. ; Abastado, J.-P.

Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.

J. Natl. Cancer Inst. 104, 1796-1807 (2012)

Bauer, J. ; Namineni, S. ; Reisinger, F. ; Zöller, J. ; Yuan, D.T. ; Heikenwälder, M.

Lymphotoxin, NF-ĸB, and cancer: The dark side of cytokines.

Dig. Dis. 30, 453-468 (2012)

Koppensteiner, H. ; Brack-Werner, R. ; Schindler, M.

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.

Retrovirol. 9:82 (2012)

Gaudin, R. ; Cunha de Alencar, B. ; Jouve, M. ; Bèrre, S. ; Le Bouder, E. ; Schindler, M. ; Varthaman, A. ; Gobert, F.-X. ; Benaroch, P.

Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages.

J. Cell Biol. 199, 467-479 (2012)

Hoos, A. ; Wolf, M.J. ; Bauer, J. ; Borsig, L. ; Heikenwälder, M.

Endothelial chemokine receptors as facilitators of tumor cell extravasation?

Oncotarget 3, 919-920 (2012)

Wohlleber, D. ; Kashkar, H. ; Gärtner, K. ; Frings, M.K. ; Odenthal, M. ; Hegenbarth, S. ; Borner, C. ; Arnold, B. ; Hämmerling, G. ; Nieswandt, B. ; van Rooijen, N. ; Limmer, A. ; Cederbrant, K. ; Heikenwälder, M. ; Pasparakis, M. ; Protzer, U. ; Dienes, H.-P. ; Kurts, C. ; Krönke, M. ; Knolle, P.A.

TNF-induced target cell killing by CTL activated through cross-presentation.

Cell Rep. 2, 478-487 (2012)

Siegler, V.D.

Charakterisierung der Rolle der Transmembrandomänen des kleinen Hepatitis B Virus Hüllproteins für die Bildung von subviralen Partikeln.

München, Technische Universität München, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2012, 160 S.

Farag, M.M.S. ; Tedjokusumo, R. ; Flechtenmacher, C. ; Asen, T. ; Stremmel, W. ; Müller, M. ; Protzer, U. ; Weigand, K.

Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

Vaccine 30, 6034-6039 (2012)

Schneider, M. ; Ackermann, K. ; Stuart, M. ; Wex, C. ; Protzer, U. ; Schatzl, H.M. ; Gilch, S.

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

J. Virol. 86, 10112-10122 (2012)

Stross, L. ; Günther, J. ; Gasteiger, G. ; Asen, T. ; Graf, S. ; Aichler, M. ; Esposito, I. ; Busch, D.H. ; Knolle, P. ; Sparwasser, T. ; Protzer, U.

Foxp3⁺ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.

Hepatology 56, 873-883 (2012)

Demmer, O. ; Frank, A.O. ; Hagn, F. ; Schottelius, M. ; Marinelli, L. ; Cosconati, S. ; Brack-Werner, R. ; Kremb, S. ; Wester, H.J. ; Kessler, H.

A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity.

Angew. Chem.-Int. Edit. 51, 8110-8113 (2012)

Dembek, C.J. ; Kutscher, S. ; Allgayer, S. ; Russo, C. ; Bauer, T. ; Hoffmann, D. ; Goebel, F.D. ; Bogner, J.R. ; Erfle, V. ; Protzer, U. ; Cosma, A.

Longitudinal changes in HIV-1-specific T-cell quality associated with viral load dynamic.

J. Clin. Virol. 55, 114-120 (2012)

Nagel, J. ; Gross, B. ; Meggendorfer, M. ; Preiss, C. ; Grez, M. ; Brack-Werner, R. ; Dietzel, S.

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Chromosoma 121, 353-367 (2012)

Wolf, M.J. ; Hoos, A. ; Bauer, J. ; Boettcher, S. ; Knust, M. ; Weber, A. ; Simonavicius, N. ; Schneider, C. ; Lang, M. ; Stürzl, M. ; Croner, R.S. ; Konrad, A. ; Manz, M.G. ; Moch, H. ; Aguzzi, A. ; van Loo, G. ; Pasparakis, M. ; Prinz, M. ; Borsig, L. ; Heikenwälder, M.

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.

Cancer Cell 22, 91-105 (2012)

Krepstakies, M. ; Lucifora, J. ; Nagel, C.H. ; Zeisel, M.B. ; Holstermann, B. ; Hohenberg, H. ; Kowalski, I. ; Gutsmann, T. ; Baumert, T.F. ; Brandenburg, K. ; Hauber, J. ; Protzer, U.

A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

J. Infect. Dis. 205, 1654-1664 (2012)

Diem, O. ; Schäffner, M. ; Seifarth, W. ; Leib-Mösch, C.

Influence of antipsychotic drugs on Human Endogenous Retrovirus (HERV) transcription in brain cells.

PLoS ONE 7:e30054 (2012)

Tschöp-Lechner, K. ; Drexler, I. ; Hammer, D. ; Neumann, D. ; Pohla, H. ; Sutter, G. ; Nößner, E. ; Issels, R.D.

Modified vaccinia virus Ankara delivers a robust surrogate marker for immune monitoring to sarcoma cells even if cells are being exposed to chemotherapy and heat treatment.

Int. J. Hyperthermia 28, 33-42 (2012)

Li, W.M. ; Rong, R. ; Zhao, S. ; Zhu, X.M. ; Zhang, K. ; Xiong, X. ; Yu, X.Q. ; Cui, Q.H. ; Li, S.Q. ; Chen, L. ; Cai, J. ; Du, J.

Proteomic analysis of metabolic, cytoskeletal and stress response proteins in human heart failure.

J. Cell. Mol. Med. 16, 59-71 (2012)

Li, S.Q. ; Zhu, J.G. ; Zhang, M.M. ; Wang, S.Y. ; Yu, L.P. ; Yang, X.C. ; Cai, J. ; Zhang, W.L. ; Chen, Y.R. ; Zhang, K. ; Popescu, L.M. ; Ma, X.L. ; Lau, W.B. ; Rong, R. ; Yu, X.Q. ; Wang, B.B. ; Li, Y.F. ; Xiao, C.S. ; Chen, A.F.

Response to letter regarding article, "Signature MicroRNA Expression Profile of Essential Hypertension and Its Novel Link to Human Cytomegalovirus Infection".

Circulation 125, E338-E339 (2012)

Hösel, M. ; Broxtermann, M. ; Janicki, H. ; Esser, K. ; Arzberger, S. ; Hartmann, P. ; Gillen, S. ; Kleeff, J. ; Stabenow, D. ; Odenthal, M. ; Knolle, P. ; Hallek, M. ; Protzer, U. ; Buning, H.

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Hepatology 55, 287-297 (2012)

Loetscher, Y. ; Wieser, A. ; Lengefeld, J. ; Kaiser, P. ; Schubert, S. ; Heikenwälder, M. ; Hardt, W.D. ; Stecher, B.

Salmonella transiently reside in luminal neutrophils in the inflamed gut.

PLoS ONE 7:e34812 (2012)

Boettcher, S. ; Ziegler, P. ; Schmid, M.A. ; Takizawa, H. ; van Rooijen, N. ; Kopf, M. ; Heikenwälder, M. ; Manz, M.G.

Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells.

J. Immunol. 188, 5824-5828 (2012)

Huang, L.R. ; Gabel, Y.A. ; Graf, S. ; Arzberger, S. ; Kurts, C. ; Heikenwälder, M. ; Knolle, P.A. ; Protzer, U.

Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

Gastroenterology 142, 1447-1450 (2012)

Hoffmann, D. ; Hutzenthaler, M. ; Seebach, J. ; Panning, M. ; Umgelter, A. ; Menzel, H. ; Protzer, U. ; Metzler, D.

Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.

Infect. Genet. Evol. 12, 461-466 (2012)

Attems, J. ; Alpar, A. ; Spence, L. ; McParland, S. ; Heikenwälder, M. ; Uhlén, M. ; Tanila, H. ; Hökfelt, T.G. ; Harkany, T.

Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.

Proc. Natl. Acad. Sci. U.S.A. 109, 6259-6264 (2012)

Koppensteiner, H. ; Banning, C. ; Schneider, C. ; Hohenberg, H. ; Schindler, M.

Macrophage internal HIV-1 is protected from neutralizing antibodies.

J. Virol. 86, 2826-2836 (2012)

Protzer, U. ; Maini, M.K. ; Knolle, P.A.

Living in the liver: Hepatic infections.

Nat. Rev. Immunol. 12, 201-213 (2012)

Panzer, M. ; Sitte, S. ; Wirth, S. ; Drexler, I. ; Sparwasser, T. ; Voehringer, D.

Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.

J. Immunol. 188, 615-623 (2012)

Malnati, M.S. ; Heltai, S. ; Cosma, A. ; Reitmeir, P. ; Allgayer, S. ; Glashoff, R.H. ; Liebrich, W. ; Vardas, E. ; Imami, N. ; Westrop, S. ; Nozza, S. ; Tambussi, G. ; Buttò, S. ; Fanales-Belasio, E. ; Ensoli, B. ; Ensoli, F. ; Tripiciano, A. ; Fortis, C. ; Lusso, P. ; Poli, G. ; Erfle, V. ; Holmes, H.

A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses.

J. Immunol. Methods 375, 46-56 (2012)

Chew, V. ; Chen, J. ; Lee, D. ; Loh, E. ; Lee, J. ; Lim, K.H. ; Weber, A. ; Slankamenac, K. ; Poon, R.T. ; Yang, H. ; Ooi, L.L. ; Toh, H.C. ; Heikenwälder, M. ; Ng, I.O. ; Nardin, A. ; Abastado, J.-P.

Chemokine-driven lymphocyte infiltration: An early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.

Gut 61, 427-438 (2012)

Kutscher, S. ; Bauer, T. ; Dembek, C.J. ; Sprinzl, M.F. ; Protzer, U.

Design of therapeutic vaccines: Hepatitis B as an example.

Microb. Biotechnol. 5, 270-282 (2012)

Brack-Werner, R.

Astrocytes and glial progenitor cells as long-term hosts of the human immunodeficiency virus.

Vortrag: 10th European Meeting on Glial Cells in Health and Disease, 13-17. September 2011, Prag. (2011)

Li, S. ; Zhu, J. ; Zhang, W. ; Chen, Y. ; Zhang, K. ; Popescu, L.M. ; Ma, X. ; Lau, W.B. ; Rong, R. ; Yu, X. ; Wang, B. ; Li, Y. ; Xiao, C. ; Zhang, M. ; Wang, S. ; Yu, L. ; Chen, A.F. ; Yang, X. ; Cai, J.

Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection.

Circulation 124, 175-184 (2011)

Silva, A. ; Weber, A. ; Bain, M. ; Reding, T. ; Heikenwälder, M. ; Sonda, S. ; Graf, R.

COX-2 is not required for the development of murine chronic pancreatitis.

Am. J. Physiol. Gastrointest. Liver Physiol. 300, G968-G975 (2011)

Meggendorfer, M. ; Rothenaigner, I. ; Tigges, B. ; Vincendeau, M. ; Brack-Werner, R.

Neurotoxicity of HIV-1 Proteins.

In: Gendelmann, H.E.* [Eds.]: The Neurology of Aids. New York, NY: Oxford Univ. Press, 2011. 275-288

Haybaeck, J. ; Zeller, N. ; Heikenwälder, M.

The parallel universe: MicroRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis.

Swiss Med. Wkly. 141:w13287 (2011)

Siegert, S. ; Huang, H.Y. ; Yang, C.Y. ; Scarpellino, L. ; Carrie, L. ; Essex, S. ; Nelson, P.J. ; Heikenwälder, M. ; Acha-Orbea, H. ; Buckley, C.D. ; Marsland, B.J. ; Zehn, D. ; Luther, S.A.

Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

PLoS ONE 6:e27618 (2011)

Wolff, H. ; Motyl, M. ; Hellerbrand, C. ; Heilmann, J. ; Kraus, B.

Xanthohumol uptake and intracellular kinetics in hepatocytes, hepatic stellate cells, and intestinal cells.

J. Agric. Food Chem. 59, 12893-12901 (2011)

Dembek, C.J.

Potential immune correlates of protection in HIV-1 infected individuals.

München, Technische Universität München, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2011, 107 S.

Diem, O.C.

Regulation der Expressionsaktivität humaner endogener Retroviren (HERVs).

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2011, 175 S.

Vincendeau, M.

Influence of the exogenous virus HIV-1 on the expression of human endogenous retroviral elements (HERVs).

München, Ludwig-Maximilian-Universität, Fakultät für Biologie, Diss., 2011, 138 S.

Stross, L.

The influence of regulatory T cells and other immunoregulators on the course of hepatitis B virus infection

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2011, 96 S.

Helfer, M.

Identifizierung von Hemmstoffen der HIV-Infektion mittels eines neuen HIV-Indikatorzellsystems.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2011, 126 S.

Lucifora, J. ; Kowalski, I. ; Xia, Y. ; Brandenburger, K. ; Protzer, U.

Novel peptide-based microbiocides inhibiting hepatitis B virus entry by preventing virus interaction with the cell surface.

J. Hepatol. 54, S33-S34 (2011)

Haybaeck, J. ; Heikenwälder, M. ; Klevenz, B. ; Schwarz, P. ; Margalith, I. ; Bridel, C. ; Mertz, K. ; Zirdum, E. ; Petsch, B. ; Fuchs, T.J. ; Stitz, L. ; Aguzzi, A.

Aerosols transmit prions to immunocompetent and immunodeficient mice.

PLoS ONE 7:e1001257 (2011)

Kang, T.W. ; Yevsa, T. ; Woller, N. ; Hoenicke, L. ; Wuestefeld, T. ; Dauch, D. ; Hohmeyer, A. ; Gereke, M. ; Rudalska, R. ; Potapova, A. ; Iken, M. ; Vucur, M. ; Weiss, S. ; Heikenwälder, M. ; Khan, S. ; Gil, J. ; Bruder, D. ; Manns, M. ; Schirmacher, P. ; Tacke, F. ; Ott, M. ; Luedde, T. ; Longerich, T. ; Kubicka, S. ; Zender, L.

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

Nature 479, 547-551 (2011)

Toufaily, C. ; Landry, S. ; Leib-Mösch, C. ; Rassart, E. ; Barbeau, B.

Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators.

Viruses 3, 2146-2159 (2011)

Vincent, I.E. ; Zannetti, C. ; Lucifora, J. ; Norder, H. ; Protzer, U. ; Hainaut, P. ; Zoulim, F. ; Tommasino, M. ; Trépo, C. ; Hasan, U. ; Chemin, I.

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

PLoS ONE 6:e26315 (2011)

Bauer, T. ; Sprinzl, M.F. ; Protzer, U.

Immune control of hepatitis B virus.

Dig. Dis. 29, 423-433 (2011)

Lucifora, J. ; Arzberger, S. ; Durantel, D. ; Belloni, L. ; Strubin, M. ; Levrero, M. ; Zoulim, F. ; Hantz, O. ; Protzer, U.

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

J. Hepatol. 55, 996-1003 (2011)

Lucifora, J. ; Zoulim, F.

The life cycle of hepatitis B virus and antiviral targets.

Future Virol. 6, 599-614 (2011)

Haupt, S. ; Tisdale, M. ; Vincendeau, M. ; Clements, M.A. ; Gauthier, D.T. ; Lance, R. ; Semmes, O.J. ; Turqueti-Neves, A. ; Nößner, E. ; Leib-Mösch, C. ; Greenwood, A.D.

Human endogenous retrovirus transcription profiles of the kidney and kidney-derived cell lines.

J. Gen. Virol. 92, 2356-2366 (2011)

Weber, A. ; Boege, Y. ; Reisinger, F. ; Heikenwälder, M.

Chronic liver inflammation and hepatocellular carcinoma: Persistence matters.

Swiss Med. Wkly. 141:w13197 (2011)

Masanetz, S. ; Lehmann, M.H.

HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide.

Virol. J. 8:35 (2011)

Huelsmann, P.M. ; Hofmann, A.D. ; Knoepfel, S.A. ; Popp, J. ; Rauch, P. ; di Giallonardo, F. ; Danke, C. ; Gueckel, E. ; Schambach, A. ; Wolff, H. ; Metzner, K.J. ; Berens, C.

A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replication.

BMC Biotechnol. 11:4 (2011)

Greenwood, A.D. ; Vincendeau, M. ; Schmädicke, A.C. ; Montag, J. ; Seifarth, W. ; Motzkus, D.

Bovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis).

Mol. Neurodegener. 6:44 (2011)

Attems, J. ; Ittner, A. ; Jellinger, K. ; Nitsch, R.M. ; Maj, M. ; Wagner, L. ; Götz, J. ; Heikenwälder, M.

Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.

J. Neural Transm. 118, 737-745 (2011)

Ebert, G. ; Poeck, H. ; Lucifora, J. ; Baschuk, N. ; Esser, K. ; Esposito, I. ; Hartmann, G. ; Protzer, U.

5' triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice.

Gastroenterology 141, 696-706 (2011)

Kastenmüller, W. ; Gasteiger, G. ; Subramanian, N. ; Sparwasser, T. ; Busch, D.H. ; Belkaid, Y. ; Drexler, I. ; Germain, R.N.

Regulatory T cells selectively control CD8⁺ T cell effector pool size via IL-2 restriction.

J. Immunol. 187, 3186-3197 (2011)

Eitz Ferrer, P. ; Potthoff, S. ; Kirschnek, S. ; Gasteiger, G. ; Kastenmüller, W. ; Ludwig, H. ; Paschen, S.A. ; Villunger, A. ; Sutter, G. ; Drexler, I. ; Häcker, G.

Induction of noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic noxa.

PLoS Pathog. 7:e1002083 (2011)

Pascutti, M.F. ; Rodríguez, A.M. ; Falivene, J. ; Giavedoni, L. ; Drexler, I. ; Gherardi, M.M.

Interplay between modified vaccinia virus Ankara and dendritic cells: Phenotypic and functional maturation of bystander dendritic cells.

J. Virol. 85, 5532-5545 (2011)

Loschko, J. ; Schlitzer, A. ; Dudziak, D. ; Drexler, I. ; Sandholzer, N. ; Bourquin, C. ; Reindl, W. ; Krug, A.B.

Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity.

J. Immunol. 186, 6718-6725 (2011)

Lückerath, K. ; Kirkin, V. ; Melzer, I.M. ; Thalheimer, F.B. ; Siele, D. ; Milani, W. ; Adler, T. ; Aguilar-Pimentel, J.A. ; Horsch, M. ; Michel, G. ; Beckers, J. ; Busch, D.H. ; Ollert, M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Staal, F.J. ; Rajalingam, K. ; Hueber, A.O. ; Strobl, L.J. ; Zimber-Strobl, U. ; Zörnig, M.

Immune modulation by Fas ligand reverse signaling: Lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.

Blood 117, 519-529 (2011)

[Eds.]

Lymphotoxin's link to carcinogenesis: friend or foe? from lymphoid neogenesis to hepatocellular carcinoma and prostate cancer.

Adv. Exp. Med. Biol. 691, 231-249 (2011)

Lucifora, J. ; Arzberger, S. ; Durantel, D. ; Strubin, M. ; Zoulim, F. ; Hantz, O. ; Protzer, U.

Hepatitis B virus X protein is required for productive infection of human hepatocytes.

J. Hepatol. 54, S49 (2011)

Marquardt, J.U. ; Quasdorff, M. ; Varnholt, H. ; Curth, H.-M. ; Mesghenna, S. ; Protzer, U. ; Goeser, T. ; Nierhoff, D.

Neighbor of punc E11, a novel oncofetal marker for hepatocellular carcinoma.

Int. J. Cancer 128, 2353-2363 (2011)

von Freyend, M.J. ; Untergasser, A. ; Arzberger, S. ; Oberwinkler, H. ; Drebber, U. ; Schirmacher, P. ; Protzer, U.

Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B.

J. Viral Hepat. 18, 216-226 (2011)

Bettermann, K. ; Vucur, M. ; Haybaeck, J. ; Koppe, C. ; Janssen, J. ; Heymann, F. ; Weber, A. ; Weiskirchen, R. ; Liedtke, C. ; Gassler, N. ; Müller, M. ; de Vos, R. ; Wolf, M.J. ; Boege, Y. ; Seleznik, G.M. ; Zeller, N. ; Erny, D. ; Fuchs, T. ; Zoller, S. ; Cairo, S. ; Buendia, M.A. ; Prinz, M. ; Akira, S. ; Tacke, F. ; Heikenwälder, M. ; Trautwein, C. ; Luedde, T.

TAK1 suppresses a NEMO-dependent but NF-κB-independent pathway to liver cancer.

Cancer Cell 17, 481-496 (2010)

Riddell, S.R. ; Protzer, U.

Grafting chimeric antigen receptors to redirect T cells: Carving the CAR.

Gene Ther. 17, 1191-1192 (2010)

Peters, R. ; Wolf, M.J. ; van den Broek, M. ; Nuvolone, M. ; Dannenmann, S. ; Stieger, B. ; Rapold, R. ; Konrad, D. ; Rubin, A. ; Bertino, J.R. ; Aguzzi, A. ; Heikenwälder, M. ; Knuth, A.K.

Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture.

PLoS ONE 5:e15689 (2010)

di Lullo, G. ; Soprana, E. ; Panigada, M. ; Palini, A. ; Agresti, A. ; Comunian, C. ; Milani, A. ; Capua, I. ; Erfle, V. ; Siccardi, A.G.

The combination of marker gene swapping and fluorescence-activated cell sorting improves the efficiency of recombinant modified vaccinia virus Ankara vaccine production for human use.

J. Virol. Methods 163, 195-204 (2010)

Diem, O.C. ; Schäffner, M. ; Frohnmeyer, M. ; Hemby, S.E. ; Frank, O. ; Seifarth, W. ; Leib-Mösch, C.

Influence of antipsychotic medication on endogenous retrovirus (ERV) expression in brain cells.

In: Daniel, R.* ; Hejnar, J.* ; Skalka, A.M.* ; Svoboda, J.* [Eds.]: Proceedings (Centennial Retrovirus Meeting, 29th April - 4th May 2010, Prague, Czech Republic). Bologna: Medimond, 2010. 39-43

Arzberger, S.

Significance of Apoptosis in Hepatitis B Virus (HBV) Infection.

München, Technische Universität München, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2010, 191 S.

Kutscher, S.

Immunomonitoring technologies for the evaluation of modified vaccinia virus Ankara expressing HIV-1 nef as a vaccine against.

München, Ludwig-Maximilians-Universität München, Fakultät für Chemie und Pharmazie, Diss., 2010, 105 S.

Vucur, M. ; Roderburg, C. ; Bettermann, K. ; Tacke, F. ; Heikenwälder, M. ; Trautwein, C. ; Luedde, T.

Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma?

Oncotarget 1, 373-378 (2010)

Moutaftsi, M. ; Tscharke, D.C. ; Vaughan, K. ; Koelle, D.M. ; Stern, L. ; Calvo-Calle, M. ; Ennis, F. ; Terajima, M. ; Sutter, G. ; Crotty, S. ; Drexler, I. ; Franchini, G. ; Yewdell, J.W. ; Head, S.R. ; Blum, J. ; Peters, B. ; Sette, A.

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Future Microbiol. 5, 221-239 (2010)

Hoffmann, D. ; Wolfarth, B. ; Hörterer, H.G. ; Halle, M. ; Reichhuber, C. ; Nadas, K. ; Tora, C. ; Erfle, V. ; Protzer, U. ; Schatzl, H.M.

Elevated Epstein-Barr virus loads and lower antibody titers in competitive athletes.

J. Med. Virol. 82, 446-451 (2010)

Lucifora, J. ; Vincent, I.E. ; Berthillon, P. ; Dupinay, T. ; Michelet, M. ; Protzer, U. ; Zoulim, F. ; Durantel, D. ; Trépo, C. ; Chemin, I.

Hepatitis B virus replication in primary macaque hepatocytes: crossing the species barrier toward a new small primate model.

Hepatology 51, 1954-1960 (2010)

Hoffmann, D. ; Seebach, J. ; Foley, B.T. ; Frösner, G. ; Nadas, K. ; Protzer, U. ; Schatzl, H.M.

Isolated norovirus GII.7 strain within an extended GII.4 outbreak.

J. Med. Virol. 82, 1058-1064 (2010)

Eisele, Y.S. ; Obermüller, U. ; Heilbronner, G. ; Baumann, F. ; Kaeser, S.A. ; Wolburg, H. ; Walker, L.C. ; Staufenbiel, M. ; Heikenwälder, M. ; Jucker, M.

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

Science 330, 980-982 (2010)

Hapfelmeier, S. ; Lawson, M.A. ; Slack, E. ; Kirundi, J.K. ; Stoel, M. ; Heikenwälder, M. ; Cahenzli, J. ; Velykoredko, Y. ; Balmer, M.L. ; Endt, K. ; Geuking, M.B. ; Curtiss, R. ; McCoy, K.D. ; Macpherson, A.J.

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses.

Science 328, 1705-1709 (2010)

Endt, K. ; Stecher, B. ; Chaffron, S. ; Slack, E. ; Tchitchek, N. ; Benecke, A. ; van Maele, L. ; Sirard, J.C. ; Mueller, A.J. ; Heikenwälder, M. ; Macpherson, A.J. ; Strugnell, R. ; von Mering, C. ; Hardt, W.D.

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea.

PLoS Pathog. 6:e1001097 (2010)

Thiele, F. ; Ljapoci, R. ; Drexler, I.

CD4⁺T cell activation against virus-encoded antigens by MVA-infected APCs.

Vortrag: 9th GfV-Workshop on Immunobiology of Viral Infections, 6-8 October 2010, Deidesheim. (2010)

Kremb, S. ; Helfer, M. ; Heller, W. ; Wolff, H. ; Kleinschmidt, A. ; Durner, J. ; Brack-Werner, R.

HIV full-replication technology for identification of novel HIV inhibitors from multiple sources.

Vortrag: HiT2010, 04 November 2010, Moskau. (2010)

Krebs, K.M. ; Böttinger, N. ; Huang, L.R. ; Bohne, F. ; Gasteiger, G. ; Arzberger, S. ; Chmielewski, M. ; Knolle, P.A. ; Abken, H. ; Protzer, U.

Adoptive T cell therapy for treatment of chronic hepatitis B.

Vortrag: 2010 International Meeting on Molecular Biology of Hepatitis B Viruses, 09-13 Oktober 2010, Taipeh, Taiwan. (2010)

Broxtermann, M. ; Esser, K. ; Gillen, S. ; Arzberger, S. ; Hösel, M. ; Lucifora, J. ; Protzer, U.

Hepatitis B virus induces innate immune response upon contact with human liver macrophages and endothelial cells, but not hepatocytes.

Vortrag: 2010 International Meeting on Molecular Biology of Hepatitis B Viruses, 09-13 Oktober 2010, Taipeh, ROC. (2010)

Stross, L. ; Gasteiger, G. ; Asen, T. ; Protzer, U.

Foxp3+ CD4+ regulatory T-cells alleviate liver inflammation and suppress antiviral T-cell responses in a murine model of acute Hepatitis B infection.

Vortrag: 2010 International Meeting on Molecular Biology of Hepatitis B Viruses, 09-13 Oktober 2010, Taipei, Taiwan. (2010)

Schittl, B. ; Bruss, V.

Interaction between the hepatitis B virus large surface protein and capsid.

Vortrag: Molecular Biology of Hepatitis B Viruses, 09 Oktober 2010, Taipei, Taiwan. (2010)

Gasteiger, G. ; Kastenmüller, W. ; Stross, L. ; Sparwasser, T. ; Busch, D.H. ; Drexler, I.

Regulatory T-cells limit acute but not memory T cell responses to acute viral infection.

Vortrag: 14th International Congress of Immunology, 22-27 August 2010, Kobe, Japan. (2010)

Gasteiger, G. ; Muschaweckh, A. ; Kastenmüller, W. ; König, P.A ; Fischer, A. ; Kisling, S. ; Baier, R. ; Busch, D.H. ; Drexler, I.

Skin-resident T cells and systemic protective immunity induced by intradermal tattoo vaccination.

Vortrag: XVIIIth International Poxvirus, Asfivirus and Iridovirus Symposium, 5-10 June 2010, Sedona (AZ), USA. (2010)

Diem, O. ; Seifarth, W. ; Frank, O. ; Leib-Mösch, C.

Regulation of Human Endogenous Retrovirus (HERV) expression in human brain cells.

Vortrag: 4th European Congress of Virology, 07-11 April 2010, Cernobbio, Como Lake, Italy. (2010)

Wolff, H. ; Greenwood, A.D.

Did viral disease of humans wipe out the Neandertals?

Med. Hypotheses 75, 99-105 (2010)

Kutscher, S. ; Allgayer, S. ; Dembek, C.J. ; Bogner, J.R. ; Protzer, U. ; Goebel, F.D. ; Erfle, V. ; Cosma, A.

MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays.

Gene Ther. 17, 1372-1383 (2010)

Arzberger, S. ; Hösel, M. ; Protzer, U.

Apoptosis of hepatitis B virus-infected hepatocytes prevents release of infectious virus.

J. Virol. 84, 11994-12001 (2010)

Quasdorff, M. ; Protzer, U.

Control of hepatitis B virus at the level of transcription.

J. Viral Hepat. 17, 527-536 (2010)

Protzer, U. ; Abken, H.

Can engineered 'Designer' T cells outsmart chronic hepatitis B?

Hepat. Res. Treat. 2010:901216 (2010)

Bailly-Maitre, B. ; Belgardt, B.F. ; Jordan, S.D. ; Coornaert, B. ; von Freyend, M.J. ; Kleinridders, A. ; Mauer, J. ; Cuddy, M. ; Kress, C.L. ; Willmes, D. ; Essig, M. ; Hampel, B. ; Protzer, U. ; Reed, J.C. ; Brüning, J.C.

Hepatic Bax inhibitor-1 inhibits IRE1α and protects from obesity-associated insulin resistance and glucose intolerance.

J. Biol. Chem. 285, 6198-6207 (2010)

Sarrazin, C. ; Berg, T. ; Ross, R.S. ; Schirmacher, P. ; Wedemeyer, H. ; Neumann, U. ; Schmidt, H.H.J. ; Spengler, U. ; Wirth, S. ; Kessler, H.H. ; Peck-Radosavljevic, M. ; Ferenci, P. ; Vogel, W. ; Moradpour, D. ; Heim, M. ; Cornberg, M. ; Protzer, U. ; Manns, M.P. ; Fleig, W.E. ; Dollinger, M.M. ; Zeuzem, S.

Update der S3-Leitlinie Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus(HCV)-Infektion, AWMF-Register-Nr.: 021/012.

Z. Gastroenterol. 48, 289-351 (2010)

Stabenow, D. ; Frings, M. ; Trück, C. ; Gärtner, K. ; Förster, I. ; Kurts, C. ; Tüting, T. ; Odenthal, M. ; Dienes, H.P. ; Cederbrant, K. ; Protzer, U. ; Knolle, P.A.

Bioluminescence imaging allows measuring CD8 T cell function in the liver.

Hepatology 51, 1430-1437 (2010)

Dembek, C.J. ; Kutscher, S. ; Heltai, S. ; Allgayer, S. ; Biswas, P. ; Ghezzi, S. ; Vicenzi, E. ; Hoffmann, D. ; Reitmeir, P. ; Tambussi, G. ; Bogner, J.R. ; Lusso, P. ; Stellbrink, H.-J. ; Santagostino, E. ; Vollbrecht, T. ; Goebel, F.D. ; Protzer, U. ; Draenert, R. ; Tinelli, M. ; Poli, G. ; Erfle, V. ; Malnati, M. ; Cosma, A.

Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection.

Aids Res. Ther. 7, 20 (2010)

Nörder, M. ; Becker, P.D. ; Drexler, I. ; Link, C. ; Erfle, V. ; Guzman, C.A.

Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.

PLoS ONE 5:e11400 (2010)

Wolf, M.J. ; Seleznik, G.M. ; Zeller, N. ; Heikenwälder, M.

The unexpected role of lymphotoxin β receptor signaling in carcinogenesis: From lymphoid tissue formation to liver and prostate cancer development.

Oncogene 29, 5006-5018 (2010)

Kremb, S. ; Helfer, M. ; Heller, W. ; Hoffmann, D. ; Wolff, H. ; Kleinschmidt, A. ; Cepok, S. ; Hemmer, B. ; Durner, J. ; Brack-Werner, R.

EASY-HIT: HIV full-replication technology forbroad discovery of multiple classes of HIV inhibitors.

Antimicrob. Agents Chemother. 54, 5257-5268 (2010)

Levin, A. ; Hayouka, Z. ; Friedler, A. ; Brack-Werner, R. ; Volsky, D.J. ; Loyter, A.

A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1.

J. Gen. Virol. 91, 1503-1513 (2010)

Vincendeau, M. ; Kramer, S. ; Hadian, K. ; Rothenaigner, I. ; Bell, J. ; Hauck, S.M. ; Bickel, C. ; Nagel, D. ; Kremmer, E. ; Werner, T. ; Leib-Mösch, C. ; Brack-Werner, R.

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

Aids 24, 2433-2442 (2010)

Meyer, N.H. ; Tripsianes, K. ; Vincendeau, M. ; Madl, T. ; Kateb, F. ; Brack-Werner, R. ; Sattler, M.

Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain.

J. Biol. Chem. 285, 28893-28901 (2010)

Meggendorfer, M. ; Weierich, C. ; Wolff, H. ; Brack-Werner, R. ; Cremer, T.

Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters.

Chromosome Res. 18, 401-417 (2010)

Levin, A. ; Hayouka, Z. ; Helfer, M. ; Brack-Werner, R. ; Friedler, A. ; Loyter, A.

Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein.

Biopolymers 93, 740-751 (2010)

Kraus, B. ; Wolff, H. ; Elstner, E.F. ; Heilmann, J.

Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages.

Naunyn-Schmiedebergs Arch. Pharmakol. 381, 541-553 (2010)

Schildgen, V. ; Ziegler, S. ; Tillmann, R.L. ; Schildgen, O.

Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case.

Virol. J. 7:167 (2010)

Brenner, C.D. ; King, S.B.S. ; Przewoznik, M. ; Wolters, I. ; Adam, C. ; Bornkamm, G.W. ; Busch, D.H. ; Röcken, M. ; Mocikat, R.

Requirements for control of B-cell lymphoma by NK cells.

Eur. J. Immunol. 40, 494-504 (2010)

Backes, S. ; Sperling, K.M. ; Zwilling, J. ; Gasteiger, G. ; Ludwig, H. ; Kremmer, E. ; Schwantes, A. ; Staib, C. ; Sutter, G.

Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2α.

J. Gen. Virol. 91, 470-482 (2010)

Hösel, M. ; Quasdorff, M. ; Wiegmann, K. ; Webb, D. ; Zedler, U. ; Broxtermann, M. ; Tedjokusumo, R. ; Esser, K. ; Arzberger, S. ; Kirschning, C.J. ; Langenkamp, A. ; Falk, C. ; Buning, H. ; Rose-John, S. ; Protzer, U.

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.

Hepatology 50, 1773-1782 (2009)

Stahl, S. ; Sacher, T. ; Bechtold, A. ; Protzer, U. ; Ganss, R. ; Hämmerling, G.J. ; Arnold, B. ; Garbi, N.

Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma.

Immunol. Lett. 123, 31-37 (2009)

von Laer, D. ; Baum, C. ; Protzer, U.

Antiviral gene therapy.

In: Kräusslich, H.G.* ; Bartenschlager, R.* [Eds.]: Antiviral Strategies.. Berlin: Springer, 2009. 265-297 (Handb. Exp. Pharmacol. ; 189)

Hadian, K. ; Vincendeau, M. ; Mäusbacher, N. ; Nagel, D. ; Hauck, S.M. ; Ueffing, M. ; Loyter, A. ; Werner, T. ; Wolff, H. ; Brack-Werner, R.

Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.

J. Biol. Chem. 284, 33384-33391 (2009)

Levin, A. ; Hayouka, Z. ; Brack-Werner, R. ; Volsky, D.J. ; Friedler, A. ; Loyter, A.

Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration.

Protein Eng. Des. Sel. 22, 753-763 (2009)

Huster, K.M. ; Stemberger, C. ; Gasteiger, G. ; Kastenmüller, W. ; Drexler, I. ; Busch, D.H.

Cutting edge: Memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.

J. Immunol. 183, 6898-6902 (2009)

Seifarth, W. ; Frank, O. ; Schreml, J. ; Leib-Mösch, C.

RetroArray - a comprehensive diagnostic DNA chip for rapid detection and identificaton of retroviruses, retroviral contaminants, and mistaken identity of cell lines.

In: Ovesen, K.* ; Matthiesen, O.* [Eds.]: DNA Fingerprinting, Sequencing and Chips. New York, NY: Nova Science Publishers, 2009. 87-118

di Bonito, P. ; Grasso, F. ; Mochi, S. ; Petrone, L. ; Fanales-Belasio, E. ; Mei, A. ; Cesolini, A. ; Laconi, G. ; Conrad, H. ; Bernhard, H. ; Dembek, C.J. ; Cosma, A. ; Santini, S.M. ; Lapenta, C. ; Donati, S. ; Muratori, C. ; Giorgi, C. ; Federico, M.

Anti-tumor CD8⁺ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 protein.

Virology 395, 45-55 (2009)

Ebert, G.

Inhibition of HBV replication by RIG-I stimulation with 5`-triphosphated siRNA in vitro and in vivo.

Köln, Universität zu Köln, Mathematisch-Naturwissenschaftliche Fakultät, Diss., 2009, 171 S.

Hadian, K.

Interaktionen des HIV-1 Rev Regulationsfaktors mit zellulären RNA-Bindungsproteinen.

München, Ludwig-Maximilian-Universität, Fakultät für Biologie, Diss., 2009, 143 S.

Treptow, T.

Identifizierung und Charakterisierung zweier neuer Proteine, die mit dem HIV-Rev-Protein interagieren

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2009, 141 S.

Deutsch, M.J.

Molekulare Studien zur Effizienz und Stabilität EBV-basierender extrachromosomaler Genvektoren.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2009, 127 S.

Muschaweckh, A. ; Gasteiger, G. ; Kastenmüller, W. ; König, P.A ; Fischer, A. ; Baier, R. ; Drexler, I.

Intradermal tattoo vaccination enhances systemic and local immunogenicity of MVA vector vaccines.

Vortrag: 8th Workshop on Imunology of Viral Infections, GfV, 7-9 October 2009, Deidesheim, Germany. (2009)

Gasteiger, G. ; Kastenmüller, W. ; Stross, L. ; Sparwasser, T. ; Busch, D.H. ; Drexler, I.

Regulatory T cells limit effector but not memory T cell responses to vaccination.

Vortrag: International Meeting 2009, 30th August - 02nd September 2009, Tour, France. (2009)

Vincendeau, M. ; Kramer, S. ; Hadian, K. ; Rothenaigner, I. ; Bell, J. ; Hauck, S.M. ; Bickel, C. ; Kremmer, E. ; Leib-Mösch, C. ; Brack-Werner, R.

A novel family of host cell factors that control hiv production by targeting rev.

Vortrag: 34th Annual Meeting on Retroviruses in CSHL, 17th May 2009, CSHL, NY, USA. (2009)

Gebefügi, E. ; Brunmeir, R. ; Weirich, C. ; Wolff, H. ; Brack-Werner, R. ; Leib-Mösch, C.

Activation of a HERV-H LTR induces expression of an aberrant calbindin protein in human prostate carcinoma cells.

Vortrag: 19th Annual Meeting of the Society for Virology (GfV), 18- 21 March 2009, Leipzig, Germany. (2009)

Vincendeau, M. ; Schreml, J. ; Seifarth, W. ; Frank, O. ; Kramer, S. ; Brack-Werner, R. ; Leib-Mösch, C.

HIV-1 infection increases the expression of several HERV families.

Vortrag: FASEB Summer Research Conference Mobile Elements in Mammalian Genomes, 05-10 July 2009, Colorado, USA. (2009)

Gailus-Durner, V. ; Fuchs, H. ; Adler, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Bolle, I. ; Calzada-Wack, J. ; Dalke, C. ; Ehrhardt, N. ; Ferwagner, B. ; Hans, W, ; Hölter, S.M. ; Hölzlwimmer, G. ; Horsch, M. ; Javaheri, A. ; Kallnik, M. ; Kling, E. ; Lengger, C. ; Mörth, C. ; Mossbrugger, I. ; Naton, B. ; Prehn, C. ; Puk, O. ; Rathkolb, B. ; Rozman, J. ; Schrewe, A. ; Thiele, F. ; Adamski, J. ; Aigner, B. ; Behrendt, H. ; Busch, D.H. ; Favor, J. ; Graw, J. ; Heldmaier, G. ; Ivandic, B. ; Katus, H.A. ; Klingenspor, M. ; Klopstock, T. ; Kremmer, E. ; Ollert, M. ; Quintanilla-Martinez, L. ; Schulz, H. ; Wolf, E. ; Wurst, W. ; Hrabě de Angelis, M.

Systemic first-line phenotyping.

Methods Mol. Biol. 530, 463-509 (2009)

Schön, U. ; Diem, O.C. ; Leitner, L. ; Günzburg, W.H. ; Mager, D.L. ; Salmons, B. ; Leib-Mösch, C.

Human endogenous retroviral long terminal repeat sequences as cell type-specific promoters in retroviral vectors.

J. Virol. 83, 12643-12650 (2009)

Bach, C.E. ; Gilch, S. ; Rost, R. ; Greenwood, A.D. ; Horsch, M. ; Hajj,G.N.M. ; Brodesser, S. ; Facius, A. ; Schädler, S. ; Sandhoff, K. ; Beckers, J. ; Leib-Mösch, C. ; Schatzl, H.M. ; Vorberg, I.

Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.

J. Biol. Chem. 284, 31260-31269 (2009)

Pairan, A. ; Bruß, V.

Functional surfaces of the hepatitis B virus capsid.

J. Virol. 83, 11616-11623 (2009)

Levin, A. ; Hayouka, Z. ; Helfer, M. ; Brack-Werner, R. ; Friedler, A. ; Loyter, A.

Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration.

PLoS ONE 4:e4155 (2009)

Kastenmüller, W. ; Gasteiger, G. ; Stross, L. ; Busch, D.H. ; Drexler, I.

Cutting edge: Mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens.

J. Immunol. 182, 2573-2577 (2009)

di Lullo, G. ; Soprana, E. ; Panigada, M. ; Palini, A. ; Erfle, V. ; Staib, C. ; Sutter, G. ; Siccardi, A.G.

Marker gene swapping facilitates recombinant Modified Vaccinia Virus Ankara production by host-range selection.

J. Virol. Methods 156, 37-43 (2009)

Lehmann, M.H. ; Kastenmüller, W. ; Kandemir, J.D. ; Brandt, F. ; Suezer, Y. ; Sutter, G.

Modified vaccinia virus ankara triggers chemotaxis of monocytes and early respiratory immigration of leukocytes by induction of CCL2 expression.

J. Virol. 83, 2540-2552 (2009)

Ohnmacht, C. ; Pullner, A. ; King, S.B.S. ; Drexler, I. ; Meier, S. ; Brocker, T. ; Voehringer, D.

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.

J. Exp. Med. 206, 549-559 (2009)

Op den Brouw, M.L. ; Binda, R.S. ; van Roosmalen, M.H. ; Protzer, U. ; Janssen, H.L. ; van der Molen, R.G. ; Woltman, A.M.

Hepatitis B virus surface antigen impairs myeloid dendritic cell function: A possible immune escape mechanism of hepatitis B virus.

Immunology 126, 280-289 (2009)

Rothenaigner, I. ; Kramer, S. ; Meggendorfer, M. ; Rethwilm, A. ; Brack-Werner, R.

Transduction of human neural progenitor cells with foamy virus vectors for differentiation-dependent gene expression.

Gene Ther. 16, 349-358 (2009)

Markoullis, K. ; Bulian, D. ; Hölzlwimmer, G. ; Quintanilla-Martinez, L. ; Heiliger, K.-J. ; Zitzelsberger, H. ; Scherb, H. ; Mysliwietz, J. ; Uphoff, C.C. ; Drexler, H.G. ; Thure, A. ; Adler, T. ; Busch, D.H. ; Schmidt, J. ; Mahabir, E.

Mycoplasma contamination of murine embryonic stem cells affects cell parameters, germline transmission and chimeric progeny.

Transgenic Res. 18, 71-87 (2009)

Kutscher, S. ; Dembek, C.J. ; Allgayer, S. ; Heltai, S. ; Stadlbauer, B. ; Biswas, P. ; Nozza, S. ; Tambussi, G. ; Bogner, J.R. ; Stellbrink, H.J. ; Goebel, F.D. ; Lusso, P. ; Tinelli, M. ; Poli, G. ; Erfle, V. ; Pohla, H. ; Malnati, M. ; Cosma, A.

The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT.

Aids Res. Ther. 5:22 (2008)

Bleifuss, E. ; Bendz, H. ; Sirch, B. ; Thompson, S. ; Brandl, A. ; Milani, V. ; Graner, M.W. ; Drexler, I. ; Kuppner, M. ; Katsanis, E. ; Nößner, E. ; Issels, R.D.

Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens.

Int. J. Hyperthermia 24, 623-637 (2008)

Meyer, V.S. ; Kastenmüller, W. ; Gasteiger, G. ; Franz-Wachtel, M. ; Lamkemeyer, T. ; Rammensee, H.-G. ; Stevanovic, S. ; Siguardardottir, D. ; Drexler, I.

Long-Term Immunity against Actual Poxviral HLA Ligands as Identified by Differential Stable Isotope Labeling.

J. Immunol. 181, 6371-6383 (2008)

Rothenaigner, I.

HIV-1 Persistenz in humanen neuralen Progenitorpopulationen.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2008, 159 S.

Sander, G. ; Konrad, A. ; Thurau, M. ; Wies, E. ; Leubert, R. ; Kremmer, E. ; Dinkel, H. ; Schulz, T. ; Neipel, F. ; Stürzl, M.

Intracellular localization map of human herpesvirus 8 proteins.

J. Virol. 82, 1908-1922 (2008)

Flockerzi, A. ; Ruggieri, A. ; Frank, O. ; Sauter, M. ; Maldener, E. ; Kopper, B. ; Wullich, B. ; Seifarth, W. ; Müller-Lantzsch, N. ; Leib-Mösch, C. ; Meese, E. ; Mayer, J.

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

BMC Genomics 9:354 (2008)

Schlosser, E. ; Mueller, M. ; Fischer, S. ; Basta, S. ; Busch, D.H. ; Gander, B. ; Groettrup, M.

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses.

Vaccine 26, 1626-1637 (2008)

Cornberg, M. ; Protzer, U. ; Dollinger, M.M. ; Petersen, J. ; Wedemeyer, H. ; Berg, T. ; Jilg, W. ; Erhardt, A. ; Wirth, S. ; Schirmacher, P. ; Fleig, W.E. ; Manns, M.P

The German guideline for the management of hepatitis B virus infection: Short version.

J. Viral Hepat. 15, (Suppl.1), 1-20 (2008)

Bohne, F. ; Chmielewski, M. ; Ebert, G. ; Wiegmann, K. ; Kürschner, T. ; Schulze, A. ; Urban, S. ; Krönke, M. ; Abken, H. ; Protzer, U.

T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.

Gastroenterology 134, 239-247 (2008)

Jenke, A.C. ; Wilhelm, A.D. ; Orth, V. ; Lipps, H.J. ; Protzer, U. ; Wirth, S.

Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.

Antimicrob. Agents Chemother. 52, 2355-2359 (2008)

Quasdorff, M. ; Hösel, M. ; Odenthal, M. ; Zedler, U. ; Bohne, F. ; Gripon, P. ; Dienes, H.P. ; Drebber, U. ; Stippel, D. ; Goeser, T. ; Protzer, U.

A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation.

Cell. Microbiol. 10, 1478-1490 (2008)

Urban, S. ; Protzer, U.

Hepatitis B virus : Lessons learned from the virus life cycle.

In: Weber, O.* ; Protzer, U.* [Eds.]: Comparative Hepatitis. Basel: Birkhäuser, 2008. 75-93

Mamani-Matsuda, M. ; Cosma, A. ; Weller, S. ; Faili, A. ; Staib, C. ; Garçon, L. ; Hermine, O. ; Beyne-Rauzy, O. ; Fieschi, C. ; Pers, J.O. ; Arakelyan, N. ; Varet, B. ; Sauvanet, A. ; Berger, A. ; Paye, F. ; Andrieu, J.M. ; Michel, M. ; Godeau, B. ; Buffet, P. ; Reynaud, C.A. ; Weill, J.C.

The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells.

Blood 111, 4653-4659 (2008)

Frank, O. ; Verbeke, C. ; Schwarz, N. ; Mayer, J. ; Fabarius, A. ; Hehlmann, R. ; Leib-Mösch, C. ; Seifarth, W.

Variable transcriptional activity of endogenous retroviruses in human breast cancer.

J. Virol. 82, 1808-1818 (2008)

Ping, G. ; Schmitt-Kopplin, P. ; Zhang, Y. ; Baba, Y.

Capillary electrochromatography and on-line concentration.

Methods Mol. Biol. 384, 751-769 (2008)

El-Gogo, S. ; Staib, C. ; Lasarte, J.J. ; Sutter, G. ; Adler, H.

Protective vaccination with hepatitis C virus NS3 but not core antigen in a novel mouse challenge model.

J. Gene Med. 10, 177-186 (2008)

Hoffmann, D. ; Seebach, J. ; Cosma, A. ; Goebel, F.D. ; Strimmer, K. ; Schatzl, H.M. ; Erfle, V.

Therapeutic vaccination reduces HIV sequence variability.

FASEB J. 22, 437-444 (2008)

Kraus, B. ; Ziegler, M. ; Wolff, H.

Linear fluorescence unmixing in cell biological research.

In: Méndez-Vilas, A.* ; Díaz, J.* [Eds.]: Modern Research and Educational Topics in Microscopy, Volume 2. Badajoz, Spain: Formatex, 2007. 863-872

Rollier, C.S. ; Paranhos-Baccala, G. ; Verschoor, E.J. ; Verstrepen, B.E. ; Drexhage, J.A. ; Fagrouch, Z. ; Berland, J.L. ; Komurian-Pradel, F. ; Duverger, B. ; Himoudi, N. ; Staib, C. ; Meyr, M. ; Whelan, M. ; Whelan, J.A. ; Adams, V.C. ; Larrea, E. ; Riezu, J.I. ; Lasarte, J.J. ; Bartosch, B. ; Cosset, F.L. ; Spaan, W.J. ; Diepolder, H.M. ; Pape, G.R. ; Sutter, G. ; Inchauspe, G. ; Heeney, J.L.

Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity.

Hepatology 45, 602-613 (2007)

Cornberg, M. ; Protzer, U. ; Dollinger, M.M. ; Petersen, J. ; Wedemeyer, H. ; Berg, T. ; Jilg, W. ; Erhardt, A. ; Wirth, S. ; Schirmacher, P. ; Fleig, W.E. ; Manns, M.P.

Prophylaxis, diagnosis and therapy of hepatitis B virus (HBV) infection: The German guidelines for the management of HBV infection.

Z. Gastroenterol. 45, 1281-1328 (2007)

Kraus, B. ; Ziegler, M. ; Wolff, H.

Linear fluorescence unmixing in cell biological research.

In: Modern Research and Educational Topics in Microscopy. Formatex, 2007. 863-872

Antonis, A.F.G. ; van der Most, R.G. ; Suezer, Y. ; Stockhofe-Zurwieden, N. ; Daus, F. ; Sutter, G. ; Schrijver, R.S.

Vaccination with recombinant modified vaccinia virus Ankara expressing bovine respiratory syncytial virus (bRSV) proteins protects calves against RSV challenge.

Vaccine 25, 4818-4827 (2007)

Gasteiger, G.

The role of antigen presentation and immunodominance for induction and expansion of cytotoxic T cell responses with MVA vector vaccines.

München, Technische Universität München, Fakultät für Medizin, Diss., 2007, 122 S.

Bruss, V.

Hepatitis B virus morphogenesis.

World J. Gastroenterol. 13, 65-73 (2007)

Ertmer, A. ; Huber, V. ; Gilch, S. ; Yoshimori, T. ; Erfle, V. ; Duyster, J. ; Elsässer, H.P. ; Schatzl, H.M.

The anticancer drug imatinib induces cellular autophagy.

Leukemia 21, 936-942 (2007)

Gudima, S. ; He, Y. ; Meier, A. ; Chang, J. ; Chen, R. ; Jarnik, M. ; Nicolas, E. ; Bruss, V. ; Taylor, J.

Assembly of hepatitis delta virus: particle characterization, including the ability to infect primary human hepatocytes.

J. Virol. 81, 3608-3617 (2007)

Gudima, S. ; Meier, A. ; Dunbrack, R. ; Taylor, J. ; Bruss, V.

Two potentially important elements of the hepatitis B virus large envelope protein are dispensable for the infectivity of hepatitis delta virus.

J. Virol. 81, 4343-4347 (2007)

Jost, S. ; Turelli, P. ; Mangeat, B. ; Protzer, U. ; Trono, D.

Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons.

J. Virol. 81, 10588-10596 (2007)

Protzer, U. ; Seyfried, S. ; Quasdorff, M. ; Sass, G. ; Svorcova, M. ; Webb, D. ; Bohne, F. ; Hösel, M. ; Schirmacher, P. ; Tiegs, G.

Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection.

Gastroenterology 133, 1156-1165 (2007)

Wedemeyer, H. ; Cornberg, M. ; Protzer, U. ; Berg, T. ; Dollinger, M.M.

[German guidelines on diagnosis and therapy of hepatitis B].

Dtsch. Med. Wochenschr. 132, 1775-1782 (2007)

Ziegler, M.

Vergleichende Untersuchung der regulierten Genexpression von integrierter und episomaler HIV-1 LTR.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2007, 169 S.

Bohne, F. ; Protzer, U.

Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B.

J. Viral Hepat. 14, (Suppl.1), 45-50 (2007)

Schlosser, E. ; Otero, C. ; Wuensch, C. ; Kessler, B. ; Edelmann, M. ; Brunisholz, R. ; Drexler, I. ; Legler, D.F. ; Groettrup, M.

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.

EMBO Rep. 8, 945-951 (2007)

Überla, K. ; Rosenwirth, B. ; Ten Haaft, P. ; Heeney, J. ; Sutter, G. ; Erfle, V.

Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy.

J. Med. Primatol. 36, 2-9 (2007)

Kastenmüller, W. ; Gasteiger, G. ; Gronau, J.H. ; Baier, R. ; Ljapoci, R. ; Busch, D.H. ; Drexler, I.

Cross-competition of CD8⁺ T cells shapes the immunodominance hierarchy during boost vaccination.

J. Exp. Med. 204, 2187-2198 (2007)

Gasteiger, G. ; Kastenmüller, W. ; Ljapoci, R. ; Sutter, G. ; Drexler, I.

Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus ankara vector vaccines.

J. Virol. 81, 11925-11936 (2007)

Bråve, A. ; Gudmundsdotter, L. ; Gasteiger, G. ; Hallermalm, K. ; Kastenmüller, W. ; Rollman, E. ; Boberg, A. ; Engström, G. ; Reiland, S. ; Cosma, A. ; Drexler, I. ; Hinkula, J. ; Wahren, B. ; Erfle, V.

Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: Study of immunological memory and long-term toxicology.

Infect. Agents Cancer 2:14 (2007)

Flockerzi, A. ; Maydt, J. ; Frank, O. ; Ruggieri, A. ; Maldener, E. ; Seifarth, W. ; Medstrand, P. ; Lengauer, T. ; Meyerhans, A. ; Leib-Mösch, C. ; Meese, E. ; Mayer, J.

Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination.

Retrovirol. 4:39 (2007)

Rothenaigner, I. ; Kramer, S. ; Ziegler, M. ; Wolff, H. ; Kleinschmidt, A. ; Brack-Werner, R.

Long-term HIV-1 infection of neural progenitor populations.

Aids 21, 2271-2281 (2007)

Kraus, B. ; Wolff, H. ; Heilmann, J. ; Elstner, E.F.

Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells.

Life Sci. 81, 884-894 (2007)

Schmitz, F. ; Heit, A. ; Guggemoos, S. ; Krug, A. ; Mages, J. ; Schiemann, M. ; Adler, H. ; Drexler, I. ; Haas, T. ; Lang, R. ; Wagner, H.

Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN- production in myeloid dendritic cells.

Eur. J. Immunol. 37, 315-327 (2007)

Zeilfelder, U. ; Frank, O. ; Sparacio, S. ; Schön, U. ; Bosch, V. ; Seifarth, W. ; Leib-Mösch, C.

The potential of retroviral vectors to cotransfer human endogenous retroviruses (HERVs) from human packaging cell lines.

Gene 390, 175-179 (2007)

El-Gogo, S. ; Staib, C. ; Meyr, M. ; Erfle, V. ; Sutter, G. ; Adler, H.

Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model.

Vaccine 25, 3934-3945 (2007)

Pammer, J. ; Reinisch, C. ; Birner, P. ; Pogoda, K. ; Stürzl, M. ; Tschachler, E.

Interferon-alpha prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulation.

Lab. Invest. 86, 997-1007 (2006)

Lehmann, M.H. ; Walter, C. ; Ylisastigui, L. ; Striebel, F. ; Ovod, V. ; Geyer, M. ; Gluckman, J.C. ; Erfle, V.

Extracellular HIV-1 Nef increases migration of monocytes.

Exp. Cell Res. 312, 3659-3668 (2006)

Lehmann, M.H. ; Masanetz, S. ; Kramer, S. ; Erfle, V.

HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner.

J. Cell Sci. 119, 4520-4530 (2006)

Wolff, H. ; Hartl, A. ; Eilken, H.M. ; Hadian, K. ; Ziegler, M. ; Brack-Werner, R.

Live-cell assay for simultaneous monitoring of expression and interaction of proteins.

BioTechniques 41, 688-692 (2006)

Marquart, K.-H.

Electron microscopy reveals fungal cells within tumor tissue from two African patients with AIDS-associated Kaposi sarcoma.

Ultrastruct. Pathol. 30, 187-192 (2006)

Wolff, H. ; Hartl, A. ; Eilken, H.M. ; Hadian, K. ; Ziegler, M. ; Brack-Werner, R.

About the Authors.

BioTechniques 41, 1 (2006)

Stengel, A. ; Roos, C. ; Hunsmann, G. ; Seifarth, W. ; Leib-Mösch, C. ; Greenwood, A.D.

Expression profiles of endogenous retroviruses in Old World monkeys.

J. Virol. 80, 4415-4421 (2006)

El-Gogo, S.

Das murine Gammaherpesvirus 68 als in vivo Modell zur Evaluierung von Antigen-spezifischen Vakzinen.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2006, 149 S.

Schäffer, E.H. ; Marquart, K.-H. ; Brandes, K. ; Kunder, S. ; Jennen, L.

Okulare Onchozerkose bei einem Hund.

Tierarztl. Prax. Ausg. K Kleintiere Heimtiere 3, 178-184 (2006)

Schormann, W. ; Kraft, A. ; Ponsel, D. ; Bruss, V.

Hepatitis B virus particle formation in the absence of pregenomic RNA and reverse transcriptase.

J. Virol. 80, 4187-4190 (2006)

Siebler, J. ; Protzer, U. ; Wirtz, S. ; Schuchmann, M. ; Höhler, T. ; Galle, P.R. ; Neurath, M.F.

Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication.

Eur. J. Gastroenterol. Hepatol. 18, 167-174 (2006)

Untergasser, A. ; Zedler, U. ; Langenkamp, A. ; Hösel, M. ; Quasdorff, M. ; Esser, K. ; Dienes, H.P. ; Tappertzhofen, B. ; Kolanus, W. ; Protzer, U.

Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection.

Hepatology 43, 539-547 (2006)

Naschberger, E. ; Lubeseder-Martellato, C. ; Meyer, N. ; Gessner, R. ; Kremmer, E. ; Gessner, A. ; Stürzl, M.

Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis.

Am. J. Pathol. 169, 1088-1099 (2006)

Stengel, A. ; Bach, C. ; Vorberg, I. ; Frank, O. ; Gilch, S. ; Lutzny, G. ; Seifarth, W. ; Erfle, V. ; Maas, E. ; Schätzl, H. ; Leib-Mösch, C. ; Greenwood, A.D.

Prion infection influences murine endogenous retrovirus expression in neuronal cells.

Biochem. Biophys. Res. Commun. 343, 825-831 (2006)

Frank, O. ; Jones-Brando, L. ; Leib-Mösch, C. ; Yolken, R. ; Seifarth, W.

Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii.

J. Infect. Dis. 194, 1447-1449 (2006)

Kastenmüller, W. ; Drexler, I. ; Ludwig, H. ; Erfle, V. ; Peschel, C. ; Bernhard, H. ; Sutter, G.

Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity.

Virology 350, 276-288 (2006)

Staib, C. ; Suezer, Y. ; Kisling, S. ; Kalinke, U. ; Sutter, G.

Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara.

J. Gen. Virol. 87, 2917-2921 (2006)

Capelli, C. ; MacPhee, R.D.E. ; Roca, A.L. ; Brisighelli, F. ; Georgiadis, N. ; O'Brien, S.J. ; Greenwood, A.D.

A nuclear DNA phylogeny of of the woolly mammoth (Mammuthus primigenius).

Mol. Phylogenet. Evol. 40, 620-627 (2006)

Stengel, A. ; Roos, C. ; Hunsmann, G. ; Seifarth, W. ; Leib-Mösch, C. ; Greenwood, A.D.

Expression profiles of endogenous in Old World Monkeys.

J. Virol. 80, 4415-4421 (2006)

Binladen, J. ; Wiuf, C. ; Gilbert, M.T.P. ; Bunce, M. ; Barnett, R. ; Larson, G. ; Greenwood, A.D. ; Haile, J. ; Ho, S.Y.W. ; Hanson, A.J. ; Willerslev, E.

Assessing the fidelity of ancient DNA sequences amplified from nuclear genes.

Genetics 172, 733-741 (2006)

Wolff, H. ; Hadian, K. ; Ziegler, M. ; Weierich, C. ; Kramer-Hämmerle, S. ; Kleinschmidt, A. ; Erfle, V. ; Brack-Werner, R.

Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging.

Exp. Cell Res. 312, 443-456 (2006)

Jörg, A. ; Grubert, T. ; Grimm, T. ; Guenzi, E. ; Naschberger, E. ; Samson, E. ; Oostendorp, R. ; Keller, U. ; Stürzl, M.

Maternal HIV type 1 infection suppresses MMP-1 expression in endothelial cells of uninfected newborns: Nonviral vertical transmission of HIV type 1-related effects.

Aids Res. Hum. Retrovir. 21, 940-944 (2005)

Töpolt, K.

Struktur-/Funktionsanalyse des humanen Guanylatbindungsproteins-1 (GBP-1) - einem Inhibitor der endothelialen Zellproliferation.

München, Ludwig-Maximilians-Universität, Diss., 2005, 175 S.

Kleinschmidt, A. ; Erfle, V.

Impfungen gegen HIV - ein langer Weg.

Klinikarzt 34, 337-341 (2005)

MacPhee, R.D. ; Tikhonov, A.N. ; Mol, D. ; Greenwood, A.D.

Late quaternary loss of genetic diversity in muskox (Ovibos).

BMC Evol. Biol. 5:49 (2005)

Collin, N. ; Guérin, J.-L. ; Drexler, I. ; Blanié, S. ; Gelfi, J. ; Boullier, S. ; Foucras, G. ; Sutter, G. ; Messud-Petit, F.

The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules.

Virology 343, 171-178 (2005)

Erfle, V. ; Göbel, F.D. ; Guzman, C. A. ; Le Grand, R.

Vaccines based on Nef and on Nef/(Delta)V2 Env.

Microbes Infect. 7, 1400-1404 (2005)

Dumortier, J. ; Schönig, K. ; Oberwinkler, H. ; Löw, R. ; Giese, T. ; Bujard, H. ; Schirmacher, P. ; Protzer, U.

Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice.

Gene Ther. 12, 668-677 (2005)

Isogawa, M. ; Kakimi, K. ; Kamamoto, H. ; Protzer, U. ; Chisari, F.V.

Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen.

Virology 333, 293-300 (2005)

Kluge, B. ; Schläger, M. ; Pairan, A. ; Bruss, V.

Determination of the minimal distance between the matrix and transmembrane domains of the large hepatitis B virus envelope protein.

J. Virol. 79, 7918-7921 (2005)

Shin, E.C. ; Protzer, U. ; Untergasser, A. ; Feinstone, S.M. ; Rice, C.M. ; Hasselschwert, D. ; Rehermann, B.

Liver-directed gamma interferon gene delivery in chronic hepatitis C.

J. Virol. 79, 13412-13420 (2005)

Kramer-Hämmerle, S. ; Hahn, A. ; Brack-Werner, R. ; Werner, T.

Elucidating effects of long-term expression of HIV-1 Nef on astrocytes by microarray, promoter, and literature analyses.

Gene 358, 31-38 (2005)

Kramer-Hämmerle, S. ; Rothenaigner, I. ; Wolff, H. ; Bell, J.E.

Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus.

Virus Res. 111, 194-213 (2005)

Kramer-Hämmerle, S. ; Ceccherini-Silberstein, F. ; Bickel, C. ; Wolff, H. ; Vincendeau, M. ; Werner, T. ; Erfle, V. ; Brack-Werner, R.

Identification of a novel Rev-interacting cellular protein.

BMC Cell Biol. 6:20 (2005)

Lux, Ch. ; Albiez, H. ; Chapman, R.D. ; Heidinger, M. ; Meininghaus, M. ; Brack-Werner, R. ; Lang, A. ; Ziegler, M. ; Cremer, T. ; Eick, D.

Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II.

Nucleic Acids Res. 33, 5139-5144 (2005)

Schäffer, E.H. ; Quintanilla-Martinez, L. ; Marquart, K.-H. ; Kunder, S. ; Scheel, C. ; Jennen, L.

Perikardiales malignes Mesotheliom beim Beagle: Fallbericht mit immunohistochemischen und elektronenmikroskopischen Befunden.

Tierarztl. Prax. Ausg. K Kleintiere Heimtiere 33, 334-340 (2005)

Grimm, T. ; Schneider, S. ; Naschberger, E. ; Huber, J. ; Guenzi, E. ; Kieser, A. ; Reitmeir, P. ; Schulz, T.F. ; Morris, C.A. ; Stürzl, M.

EBV latent membrane protein-1 protects B cells from apoptosis by inhibition of BAX.

Blood 105, 3263-3269 (2005)

Hariton-Gazal, E. ; Rosenbluh, J. ; Zakai, N. ; Fridkin, G. ; Brack-Werner, R. ; Wolff, H. ; Devaux, C. ; Gilon, C. ; Loyter, A.

Functional analysis of backbone cyclic peptides bearing the arm domain of the HIV-1 Rev protein: Characterization of the karyophilic and inhibition of Rev-induced gene expression.

Biochemistry 44, 11555-11566 (2005)

Frank, O. ; Giehl, M. ; Zheng, C. ; Hehlmann, R. ; Leib-Mösch, C. ; Seifarth, W.

Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders.

J. Virol. 79, 10890-10901 (2005)

Staib, C. ; Kisling, S. ; Erfle, V. ; Sutter, G.

Inactivation of the viral interleukin 1ß receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara.

J. Gen. Virol. 86, 1997-2006 (2005)

Ludwig, H. ; Mages, J. ; Staib, C. ; Lehmann, M.H. ; Lang, R. ; Sutter, G.

Role of viral factor E3L in modified vaccinia virus Ankara infection of human HeLa cells: Regulation of the virus life cycle and identification of differentially expressed host genes.

J. Virol. 79, 2584-2596 (2005)

Marquart, K.-H.

Occurence of tubuloreticular structures and intracisternal paracrystalline inclusions in endothelial cells of tissue from different epidemiological types of Kaposi's sarcoma.

Ultrastruct. Pathol. 29, 85-93 (2005)

Greenwood, A.D. ; Stengel, A. ; Erfle, V. ; Seifarth, W. ; Leib-Mösch, C.

The distribution of pol containing human endogenous retroviruses in non-human primates.

Virology 334, 203-213 (2005)

Meyer, R.G. ; Drexler, I. ; Sutter, G. ; Jakob, T.

A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).

Cancer Immunol. Immunother. 54, 453-467 (2005)

Paschen, A. ; Jing, W. ; Drexler, I. ; Klemm, M. ; Song, M. ; Müller-Berghaus, J. ; Nguyen, X.D. ; Osen, W. ; Stevanovic, S. ; Sutter, G. ; Schadendorf, D.

Melanoma patients respond to a new HLA-1*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

Int. J. Cancer 116, 944-948 (2005)

Greenwood, A.D. ; Leib-Mösch, C. ; Seifarth, W.

Abyss1: a novel L2-like non-LTR retroelement of the snakelocks anemone (Anemonia sulcata).

Cytogenet. Genome Res. 110, 553-558 (2005)

Greenwood, A.D. ; Horsch, M. ; Stengel, A. ; Vorberg, I. ; Lutzny, G. ; Maas, E. ; Schädler, S. ; Erfle, V. ; Beckers, J. ; Schätzl, H. ; Leib-Mösch, C.

Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells.

J. Mol. Biol. 349, 487-500 (2005)

Seifarth, W. ; Frank, O. ; Zeilfelder, U. ; Spiess, B. ; Greenwood, A.D. ; Hehlmann, R. ; Leib-Mösch, C.

Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray.

J. Virol. 79, 341-352 (2005)

Kramer-Hämmerle, S. ; Rothenaigner, I. ; Brack-Werner, R.

Differenzierung einer humanen neuralen Stammzelllinie unter verschiedenen Wachstumsbedingungen.

BioSpektrum 6, 796-798 (2004)

Naschberger, E.

A NF-kB motif and ISRE cooperate in the activation of guanylate binfing protein-1 expression by inflammatory cytokines in endothelial cells.

Innsbruck, Leopold-Franzens-Universität, Diss., 2004, 80 S.

Koopman, G. ; Mortier, D. ; Hofmann, S.M. ; Niphuis, H. ; Fagrouch, Z. ; Norley, S. ; Sutter, G. ; Liljeström, P. ; Heeney, J.L.

Vaccine protection from CD4⁺ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.

J. Gen. Virol. 85, 2915-2924 (2004)

Olszewska, W. ; Suezer, Y. ; Openshaw, P.J.M.

Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins.

Vaccine 23, 215-221 (2004)

Drexler, I. ; Staib, C. ; Sutter, G.

Modified vaccinia virus Ankara as antigen delivery system: How can we best use its potential.

Curr. Opin. Biotechnol. 15, 506-512 (2004)

Mäkitalo, B. ; Sutter, G. ; Erfle, V.

Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen.

J. Gen. Virol. 85, 2407-2419 (2004)

Rafalska, I. ; Zhang, Z. ; Benderska, N. ; Wolff, H. ; Hartmann, A.M. ; Brack-Werner, R. ; Stamm, S.

The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.

Hum. Mol. Genet. 13, 1535-1549 (2004)

Greenwood, A.D. ; Engelbrecht, C.C. ; MacPhee, R.D.E.

Characterization of an endogenous retrovirus class in elephants and their relatives.

BMC Evol. Biol. 4:38 (2004)

Bruss, V.

Processing of hepatitis B virus surface proteins.

Methods Mol. Med. 95, 189-198 (2004)

[Eds.]

Envelopment of the hepatitis B virus nucleocapsid.

Virus Res. 106, 199-209 (2004)

Hultström, A.L. ; Bratt, G. ; Cosma, A. ; Erfle, V. ; Wahren, B. ; Carbone, E.

Autologous cytotoxicity of natural killer cells derived from HIV-infected patients.

Immunol. Lett. 91, 155-158 (2004)

Sprinzl, M. ; Dumortier, J. ; Protzer, U.

Construction of recombinant adenoviruses that produce infectious hepatitis B virus.

Methods Mol. Med. 96, 209-218 (2004)

Untergasser, A. ; Protzer, U.

Hepatitis B virus-based vectors allow the elimination of viral gene expression and the insertion of foreign promoters.

Hum. Gene Ther. 15, 203-210 (2004)

Zhang, Z. ; Protzer, U. ; Hu, Z. ; Jacob, J. ; Liang, T.J.

Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.

J. Virol. 78, 4566-4572 (2004)

Jörg, A.

Auswirkungen der maternalen HIV-1-Infektion auf die Genexpression endothelialer Vorläuferzellen und differenzierter Endothelzellen nicht-infizierter Kinder.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 2004, 144 S.

Hermann, F. ; Lehr, H.-A. ; Drexler, I. ; Sutter, G. ; Hengstler, J. ; Wollscheid, U. ; Seliger, B.

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

Cancer Res. 64, 215-220 (2004)

Lotz, C. ; Ferreira, E.A. ; Drexler, I. ; Mutallib, S.A. ; Huber, C. ; Sutter, G. ; Theobald, M.

Partial tyrosinase-specific self tolerance by HLA-A*0201-restricted cytotoxic T lymphocytes in mice and man.

Int. J. Cancer 108, 571-579 (2004)

Staib, C. ; Drexler, I. ; Sutter, G.

Construction and isolation of recombinant MVA.

Methods Mol. Biol. 269, 77-99 (2004)

Matzen, K. ; Dirkx, A.E.M. ; Egbrink, M.G.A. ; Speth, C. ; Götte, M. ; Ascherl, G. ; Grimm, T. ; Griffioen, A.W. ; Stürzl, M.

HIV-1 tat increases the adhesion of monocytes and T-cells to the endothelium in vitro and in vivo: Implications for AIDS-associated vasculopathy.

Virus Res. 104, 145-155 (2004)

Naschberger, E. ; Werner, T. ; Vicente, A.B. ; Guenzi, E. ; Töpolt, K. ; Leubert, R. ; Lubseder-Martellato, C. ; Nelson, P.J. ; Stürzl, M.

Nuclear factor-kB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells.

Biochem. J. 379, 409-420 (2004)

Cosma, A. ; Bühler, S. ; Nagaraj, R. ; Staib, C. ; Hammarin, A.-L. ; Wahren, B. ; Goebel, F.D. ; Erfle, V. ; Sutter, G.

Neutralization assay using a modified vaccinia virus Ankara vector expressing the green fluorescent protein is a high-throughput method to monitor the humoral immune response against vaccinia virus.

Clin. Diagn. Lab. Immunol. 11, 406-410 (2004)

Leib-Mösch, C. ; Seifarth, W. ; Schön, U.

Influence of Human Endogenous Retroviruses on Cellular Gene Expression.

In: Sverdlov, E.* [Eds.]: Retroviruses and Primate Genome Evolution. Georgetown, TX: Landes Bioscience, 2004. 123-143

Wolff, H.

Entwicklung von zellulären Indikatorsystemen zur Identifikation von Modulatoren der HIV-1 Genexpression.

München, Ludwig-Maximilians-Universität, Diss., 2003, 209 S.

Lubeseder-Martellato, C.

The guanylate binding protein-1 : A molecular marker of the inflammatory cytokine-activated phenotype of endothelial cells.

München, Ludwig-Maximilians-Universität, Diss., 2003, 132 S.

di Nicola, M. ; Carlo-Stella, C. ; Anichini, A. ; Mortarini, R. ; Guidetti, A. ; Tragni, G. ; Gallino, F. ; del Vecchio, M. ; Ravagnani, F. ; Morelli, D. ; Chaplin, P. ; Arndtz, N. ; Sutter, G.

Immunization of Patients with Malignant Melanoma with Autologous CD34+ Cell-Derived Dendritic Cells Transduced Ex Vivo with a Recombinant Replication-Deficient Vaccinia Vector Encoding the Human Tyrosinase Gene : A Phase I Trial.

Hum. Gene Ther. 14, 1347-1360 (2003)

Demart, S. ; Ceccherini-Silberstein, F. ; Schlicht, St. ; Walcher, S. ; Wolff, H. ; Neumann, M. ; Erfle, V. ; Brack-Werner, R.

Analysis of nuclear targeting activities of transport signals in the human immunodeficiency virus Rev protein.

Exp. Cell Res. 291, 484-509 (2003)

Bukur, J. ; Rebmann, V. ; Grosse-Wilde, H. ; Luboldt, H. ; Ruebben, H. ; Drexler, I. ; Sutter, G. ; Huber, C. ; Seliger, B.

Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma.

Cancer Res. 63, 4107-4111 (2003)

Klöcker, U. ; Oberwinkler, H. ; Kürschner, T. ; Protzer, U.

Presence of replicating virus in recombinant hepadnavirus stocks results from recombination and can be eliminated by the use of a packaging cell line.

J. Virol. 77, 2873-2881 (2003)

Ponsel, D. ; Bruss, V.

Mapping of amino acid side chains on the surface of hepatitis B virus capsids required for envelopment and virion formation.

J. Virol. 77, 416-422 (2003)

Ritz, U. ; Drexler, I. ; Sutter, D. ; Abele, R. ; Huber, C. ; Seliger, B.

Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.

J. Immunol. 170, 941-946 (2003)

Schulze-Bergkamen, H. ; Untergasser, A. ; Dax, A. ; Vogel, H. ; Büchler, P. ; Klar, E. ; Lehnert, T. ; Friess, H. ; Büchler, M.W. ; Kirschfink, M. ; Stremmel, W. ; Krammer, P.H. ; Müller, M. ; Protzer, U.

Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection.

J. Hepatol. 38, 736-744 (2003)

Staib, C. ; Sutter, G.

Live viral vectors: Vaccinia virus.

Methods Mol. Med. 87, 51-68 (2003)

Vogel, T.U. ; Reynolds, M.R. ; Fuller, D.H. ; Vielhuber, K. ; Shipley, T. ; Fuller, J.T. ; Kunstman, K.J. ; Sutter, G. ; Marthas, M.L. ; Erfle, V. ; Wolinsky, S.M. ; Wang, C. ; Allison, D.B. ; Rud, E.W. ; Wilson, N. ; Montefiori, D. ; Altman, J.D. ; Watkins, D.I.

Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.

J. Virol. 77, 13348-13360 (2003)

Cosma, A. ; Nagaraj, R. ; Bühler, S. ; Hinkula, J. ; Busch, D.H. ; Sutter, G. ; Goebel, F.D. ; Erfle, V.

Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals.

Vaccine 22, 21-29 (2003)

Ma, S.L. ; Lovmand, J. ; Sorensen, A.B. ; Luz, A. ; Schmidt, J. ; Pedersen, F.S.

Triple basepair changes within and adjacent to the conserved YY1 motif upstream of the U3 enhancer repeats SL3-3 murine leukemia virus cause a small but significant shortening of latency of T-lymphoma induction.

Virology 313, 638-644 (2003)

Seifarth, W. ; Spiess, B. ; Zeilfelder, U. ; Speth, C. ; Hehlmann, R. ; Leib-Mösch, C.

Assessment of retroviral activity using a universal retrovirus chip.

J. Virol. Methods 112, 79-91 (2003)

Sutter, G. ; Staib, C.

Vaccinia Vectors as Candidate Vaccines : the Development of Modified Vaccinia Virus Ankara for Antigen Delivery.

Curr. Drug Targ. - Infect. Disord. 3, 263-271 (2003)

Guenzi, E. ; Töpolt, K. ; Lubeseder-Martellato, C. ; Jörg, A. ; Naschberger, E. ; Benelli, R. ; Albini, A. ; Stürzl, M.

The granylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression.

EMBO J. 22, 3772-3782 (2003)

Wolff, H. ; Brack-Werner, R. ; Neumann, M. ; Werner, T. ; Schneider, R.

Integrated functional and bioinformatics approach for the identification and experimental verification of RNA signals : Application to HIV-1 INS.

Nucleic Acids Res. 31, 2839-2851 (2003)

Anderson, C.E. ; Tomlinson, G.S. ; Pauly, B. ; Brannan, F.W. ; Chiswick, A. ; Brack-Werner, R. ; Simmonds, P. ; Bell, J.E.

Relationship of Nef-positive and GFAP-reactive astrocytes to drug use in early and late HIV infection.

Neuropathol. Appl. Neurobiol. 29, 378-388 (2003)

Öhlschläger, P. ; Osen, W. ; Dell, K. ; Faath, S. ; Garcea, R.L. ; Jochmus, I. ; Müller, M. ; Pawlita, M. ; Schäfer, K. ; Sehr, P. ; Staib, C. ; Sutter, G. ; Gissmann, L.

Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice.

J. Virol. 77, 4635-4645 (2003)

Hornemann, S. ; Harlin, O. ; Staib, C. ; Kisling, S. ; Erfle, V. ; Kaspers, B. ; Häcker, G. ; Sutter, G.

Replication of Modified Vaccinia Virus Ankara in Primary Chicken Embryo Fibroblasts Requires Expression of the Interferon Resistance Gene E3L.

J. Virol. 77, 8394-8407 (2003)

Meiser, A. ; Boulanger, D. ; Sutter, G. ; Krijnse Locker, J.

Comparison of virus production in chicken embryo fibroblasts infected with the WR, IHD-J and MVA strains of vaccinia virus : IHD-J is most efficient in trans-Golgi network wrapping and extracellular eveloped virus release.

J. Gen. Virol. 84, 1383-1392 (2003)

Marquart, K.-H.

Curvilinear Membranous Formations in Lymph Node Cells of an African AIDS Patient with Tuberculosis.

Ultrastruct. Pathol. 27, 49-53 (2003)

Bronte, V. ; Serafini, P. ; de Santo, C. ; Marigo, I. ; Tosello, V. ; Mazzoni, A. ; Segal, D.M. ; Staib, C. ; Löwel, M. ; Sutter, G. ; Colombo, M.P. ; Zanovello, P.

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice.

J. Immunol. 170, 270-278 (2003)

Staib, C. ; Löwel, M. ; Erfle, V. ; Sutter, G.

Improved Host Range Selection for Recombinant Modified Vaccinia Virus Ankara.

BioTechniques 34, 694-700 (2003)

Drexler, I. ; Staib, C. ; Kastenmüller, W. ; Stevanovic, St. ; Schmidt, B. ; Lemonnier, F.A. ; Rammensee, H.-G. ; Busch, D.H. ; Bernhard, H. ; Erfle, V. ; Sutter, G.

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.

Proc. Natl. Acad. Sci. U.S.A. 100, 217-222 (2003)

Spiess, B. ; Buchheidt, D. ; Baust, C. ; Skladny, H. ; Seifarth, W. ; Zeilfelder, U. ; Leib-Mösch, C. ; Mörz, H. ; Hehlmann, R.

Development of a LightCycler PCR Assay for Detection and Quantification of Aspergillus fumigatus DNA in Clinical Samples from Neutropenic Patients.

J. Clin. Microbiol. 41, 1811-1818 (2003)

Nilsson, C. ; Sutter, G. ; Jallow-Walther, L. ; Ten Haaft, P. ; Akerblom, L. ; Heeney, J. ; Erfle, V. ; Böttiger, P. ; Biberfeld, G. ; Thorstensson, R.

Immunization with recombinant modified vaccinia virus Ankara can modify mucosal simian immunodeficiency virus infection and delay disease progression in macaques.

J. Gen. Virol. 83, 807-818 (2002)

Verrier, B. ; Le Grand, R. ; Ataman-Önal, Y. ; Terrat, C. ; Guillon, C. ; Durand, P.-Y. ; Hurtrel, B. ; Aubertin, A.-M. ; Sutter, G. ; Erfle, V. ; Girard, M.

Evaluation in Rhesus Macaques of Tat and Rev-Target Immunization as a Preventive Vaccine against Mucosal Challenge with SHIV-BX08.

DNA 21, 653-658 (2002)

Vogel, T.U. ; Horton, H. ; Fuller, D.H. ; Carter, D.K. ; Vielhuber, K. ; O'Connor, D. ; Shipley, T. ; Fuller, J. ; Sutter, G. ; Erfle, V. ; Wilson, N. ; Picker, L.J. ; Watkins, D.I.

Differences Between T Cell Epitopes Recognized After Immunization and After Infection.

J. Immunol. 169, 4511-4521 (2002)

Guérin, J.-L. ; Gelfi, J. ; Boullier, S. ; Delverdier, M. ; Bellanger, F.-A. ; Bertagnoli, S. ; Drexler, I. ; Sutter, G. ; Messud-Petit, F.

Myxoma Virus Leukemia-Associated Protein is Responsible for Major Histocompatibility Complex Class I and Fas-CD95 Down-Regulation and Defines Scrapins, a New Group of Surface Cellular Receptor Abductor Proteins.

J. Virol. 76, 2912-2923 (2002)

Horton, H. ; Vogel, T.U. ; Carter, D.K. ; Vielhuber, K. ; Fuller, D.H. ; Shipley, T. ; Fuller, J.T. ; Kunstmann, K.J. ; Sutter, G. ; Montefiori, D.C. ; Erfle, V. ; Desrosiers, R.C. ; Wilson, N.

Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239.

J. Virol. 76, 7187-7202 (2002)

Hariton-Gazal, E. ; Feder, R. ; Graessmann, A. ; Brack-Werner, R. ; Jans, D. ; Gilon, C. ; Loyter, A.

Targeting of Nonkaryophilic Cell-Permeable Peptides into the Nuclei of Intact Cells by Covalently Attached Nuclear Localization Signals.

Biochemistry 41, 9208-9214 (2002)

Schön, U. ; Erfle, V. ; Leib-Mösch, C.

Impact of human endogenous retroviral long terminal repeats on cellular genes.

In: Recent research developments in virology. 2002. 77-86 ( ; 4)

Stittelaar, K.J. ; Gruters, R.A. ; Schutten, M. ; van Baalen, C.A. ; van Amerongen, G. ; Cranage, M. ; Liljeström, P. ; Sutter, G. ; Osterhaus, A.D.M.E.

Comparison of the efficacy of early versus late viral proteins in vaccination against SIV.

Vaccine 20, 2921-2927 (2002)

Boulanger, D. ; Baier, R. ; Erfle, V. ; Sutter, G.

Generation of recombinant fowlpox virus using the non-essential F11L orthologue as insertion site and a rapid transient selection strategy.

J. Virol. Methods 106, 141-151 (2002)

Britten, C.M. ; Meyer, R.G. ; Kreer, T. ; Drexler, I. ; Wölfel, Th. ; Herr, W.

The use of HLA-A* 0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-y ELISPOT assays.

J. Immunol. Methods 259, 95-110 (2002)

Allen, T.M. ; Mortara, L. ; Mothe, B.R. ; Liebl, M. ; Jing, P. ; Calore, B. ; Piekarczyk, M. ; Rudersdorf, R. ; O'Connor, D.H. ; Wang, X. ; Wang, C. ; Allison, D.B. ; Altman, J.D. ; Sette, A. ; Desrosiers, R.C. ; Sutter, G. ; Watkins, D.I.

Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication.

J. Virol. 76, 4108-4112 (2002)

Töpolt, K. ; Guenzi, E. ; Lubeseder-Martellato, C. ; Jörg, A. ; Naschberger, E. ; Stürzl, M.

Structure-Function Analysis of the Anti-proliferative Effect of the Human Guanylate Binding Protein-1 (GBP-1) in Endothelial Cells.

In: Tooke, J.* ; Shore, A.* ; Whatmore, J.* [Eds.]: Proceedings (22. Meeting of the European Society for Microcirculation : The Microcirculation and Vascular Biology, Exeter, UK, 28.08. - 30.0). Bologna: Monduzzi Editore, 2002. 215-219

Lubeseder-Martellato, C. ; Guenzi, E. ; Jörg, A. ; Töpolt, K. ; Naschberger, E. ; Kremmer, E. ; Zietz, C. ; Tschachler, E. ; Hutzler, P. ; Schwemmle, M. ; Matzen, K. ; Grimm, Th. ; Ensoli, B.

Guanylate-Binding Protein-1 Expression is Selectively Induced by Inflammatory Cytokines and is an Activation Marker of Endothelial Cells during Inflammatory Diseases.

Am. J. Pathol. 161, 1749-1759 (2002)

Kohleisen, B. ; Hutzler, P. ; Shumay, E. ; Ovod, V. ; Erfle, V.

HIV-1 Nef co-localizes with the astrocyte-specific cytoskeleton protein GFAP in persistently nef- expressing human astrocytes.

J. Neurovirol. 7, 52-55 (2001)

Nilsson, C. ; Mäkitalo, B. ; Berglund, P. ; Bex, F. ; Liljeström, P. ; Sutter, G. ; Erfle, V. ; Ten Haaft, P. ; Heeney, J. ; Biberfeld, G. ; Thorstensson, R.

Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara.

Vaccine 19, 3526-3536 (2001)

Schön, U. ; Seifarth, W. ; Baust, C. ; Hohenadl, C. ; Erfle, V. ; Leib-Mösch, C.

Cell Type-Specific Expression and Promoter Activity of Human Endogenous Retroviral Long Terminal Repeats.

Virology 279, 280-291 (2001)

Scherf, M. ; Klingenhoff, A. ; Frech, K. ; Quandt, K. ; Schneider, R. ; Grote, K. ; Frisch, M. ; Gailus-Durner, V. ; Seidel, A. ; Brack-Werner, R. ; Werner, T.

First pass annotation of promoters on human chromosome 22.

Genome Res. 11, 333-340 (2001)

Ensoli, B. ; Sgadari, C. ; Barillari, G. ; Sirianni, M.C. ; Stürzl, M. ; Monini, P.

Biology of Kaposi's sarcoma.

Eur. J. Cancer 37, 1251-1269 (2001)

Ascherl, G. ; Sgadari, C. ; Bugarini, R. ; Bogner, J. ; Schatz, O. ; Ensoli, B. ; Stürzl, M.

Serum concentrations of fibroblast growth factor 2 are increased in HIV type 1-infected patients related to survival probability.

Aids Res. Hum. Retrovir. 17, 1035-1039 (2001)

Grimm, Th. ; Stürzl, M. ; Jennen, L.

HIV-1 und HHV-8 : eine tumorigene Allianz in der Pathogenese des Kaposi-Sarkoms.

BIOforum 5, 328-331 (2001)

Stürzl, M. ; Zietz, Ch. ; Monini, P. ; Ensoli, B.

Human Herpesvirus-8 and Kaposi's Sarcoma : Relationship with the Multistep Concept of Tumorgenesis.

Adv. Cancer Res., 125-159 (2001)

Rimessi, P. ; Bonaccorsi, A. ; Stürzl, M. ; Fabris, M. ; Brocca-Cofano, E. ; Caputo, A. ; Melucci-Vigo, G. ; Falchi, M. ; Cafaro, A. ; Cassai, E. ; Ensoli, B. ; Monini, P.

Transcription Pattern of Human Herpesvirus 8 Open Reading Frame K3 in Primary Effusion Lymphoma and KaposiS Sarcoma.

J. Virol. 75, 7161-7174 (2001)

Sutter, G. ; Haas, J.

Novel vaccine delivery systems : Solutions to HIV vaccine dilemmas ?.

Aids 15, 5, 139-145 (2001)

Kramer-Hämmerle, S. ; Kohleisen, B. ; Hohenadl, Ch. ; Shumay, E. ; Becker, I. ; Erfle, V. ; Schmidt, J.

HIV Type 1 Nef Promotes Neoplastic Transformation of Immortalized Neural Cells.

Aids Res. Hum. Retrovir. 17, 597-602 (2001)

Neumann, M. ; Afonina, E. ; Ceccherini-Silberstein, F. ; Schlicht, S. ; Erfle, V. ; Pavlakis, G.N. ; Brack-Werner, R.

Nucleocytoplasmic transport in human astrocytes: Decreased nuclear uptake of the HIV Rev shuttle protein.

J. Cell Sci. 114, 1717-1729 (2001)

Seifarth, W. ; Baust, C. ; Schön, U. ; Reichert, A. ; Hehlmann, R. ; Leib-Mösch, C.

HERV-IP-T47D: a Novel Type C-Related Human Endogenous Retroviral Sequence Derived from T47D Particles.

Aids Res. Hum. Retrovir. 16, 471-480 (2000)

Seifarth, W. ; Krause, U. ; Hohenadl, C. ; Baust, C. ; Hehlmann, R. ; Leib-Mösch, C.

Rapid identification of all known retroviral reverse transcriptase sequences with a novel versatile detection assay.

Aids Res. Hum. Retrovir. 16, 721-729 (2000)

Cota, M. ; Kleinschmidt, A. ; Ceccherini-Silberstein, F. ; Aloisi, F. ; Mengozzi, M. ; Mantovani, A. ; Brack-Werner, R. ; Poli, G.

Upregulated expression of interleukin-8, RANTES and chemokine receptors in human astrocytic cells infected with HIV-1.

J. Neurovirol. 6, 75-83 (2000)

Collings, A. ; Pitkänen, J. ; Strengell, M. ; Tähtinen, M. ; Lagerstedt, A. ; Hakkarainen, K. ; Ovod, V. ; Sutter, G. ; Ustav, M. ; Ustav, E. ; Männik, A.

Humoral and cellular immune responses to HIV-1 Nev in mice DNA-immunised with non- replicating or self-replicating expression vectors.

Vaccine 18, 460-467 (2000)

Baust, C. ; Seifarth, W. ; Germaier, H. ; Hehlmann, R. ; Leib-Mösch, C.

Genomics 66, 98-103 (2000)

Graham, V.V. ; Sutter, G. ; Jose, M.V. ; Garcia-Carranca, A. ; Erfle, V. ; Mendoza, N.M. ; Merchant, H. ; Rosales, R.

Human Tumor Growth is Inhibited by a Vaccinia Virus Carrying the E2 Gene of Bovine Papillomavirus.

Cancer 88, 1650-1662 (2000)

Sgadari, C. ; Toschi, E. ; Palladino, C. ; Barillari, G. ; Carlei, D. ; Cereseto, A. ; Ciccolella, C. ; Yarchoan, R. ; Monini, P. ; Stürzl, M. ; Ensoli, B.

Mechanism of Paclitaxel Activity in Kaposi's Sarcoma.

J. Immunol. 165, 509-517 (2000)

Kramer, S.

Biologische Effekte von konstitutiv HIV-1 Nef in Zellen des Zentralen Nervensystems der Maus.

2000, 138 S. (Zugl. Tierärztliche Fakultät, LMU München, Diss., 2000)

Ensoli, B. ; Stürzl, M. ; Monini, P.

Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effuaion lymphoma.

Semin. Cancer Biol. 10, 367-381 (2000)

Staib, C. ; Drexler, I. ; Ohlmann, M. ; Wintersperger, S. ; Erfle, V. ; Sutter, G.

Transient Host Range Selection for Genetic Engineering of Modified Vaccinia Virus Ankara.

BioTechniques 28, 1137-1148 (2000)

Saura, M. ; Zaragoza, C. ; McMillan, A. ; Quick, R.A. ; Hohenadl, C. ; Lowenstein, J.M.

An antiviral mechanism of nitric oxide : Inhibition of a viral protease.

Immunity 10, 21-28 (1999)

Brack-Werner, R. ; Bell, J.E.

Replication of HIV-1 in Human Astrocytes.

NeuroAids 2, 1-7 (1999)

Goebel, F.-D. ; Mannhalter, J.W. ; Belshe, R.B. ; Eibl, M.M. ; de Gruttola, V. ; Griffiths, P.D. ; Erfle, V. ; Kunschak, M. ; Engl, W.

Recombinant gp160 as a therapeutic vaccine for HIV-infection: results of a large randomized, controlled trial.

Aids 13, 1461-1468 (1999)

Rosenwirth, B. ; Bogers, W.M.J.M. ; Nieuwenhuis, I.G. ; Ten Haaft, P. ; Niphuis, H. ; Kuhn, E.M. ; Bischofberger, N. ; Erfle, V. ; Sutter, G. ; Berglund, P.

An anti-HIV strategy combining chemotherapy and therapeutic vaccination.

J. Med. Primatol. 28, 195-205 (1999)

Osterhaus, A.D. ; van Baalen, C.A. ; Gruters, R.A. ; Schutten, M. ; Siebelink, C.H.J. ; Hulskotte, E.G.J. ; Tijhaar, E.J. ; Randall, R.E.R. ; van Amerongen, G. ; Fleuchaus, A.G. ; Erfle, V. ; Sutter, G.

Vaccination with Rev and Tat against AIDS.

Vaccine 17, 2713-2714 (1999)

Stürzl, M. ; Hohenadl, C. ; Zietz, C. ; Castanos-Velez, E. ; Wunderlich, A. ; Ascherl, G. ; Biberfeld, P. ; Monini, P. ; Browning, P.J. ; Ensoli, B.

Expression of K13/v-FLIP Gene of Human Herpesvirus 8 and Apoptosis in Kaposi's Sarcoma Spindle Cells.

J. Natl. Cancer Inst. 91, 1725-1733 (1999)

Ascherl, G. ; Hohenadl, C. ; Monini, P. ; Zietz, C. ; Browning, P.J. ; Ensoli, B. ; Stürzl, M.

Expression of human herpesvirus-8 (HHV-8) encoded pathogenic genes in kaposi's sarcoma ( KS) primary lesions.

Adv. Enzyme Regul. 39, 331-339 (1999)

Ascherl, G. ; Hohenadl, C. ; Schatz, O. ; Shumay, E. ; Bogner, J. ; Eckhart, L. ; Tschachler, E. ; Monini, P. ; Ensoli, B. ; Stürzl, M.

Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T-cells: Implications for acquired immunodeficiency syndrome-associated vasculopathy.

Blood 93, 4232-4241 (1999)

Stürzl, M. ; Wunderlich, A. ; Ascherl, G. ; Hohenadl, C. ; Monini, P. ; Zietz, C. ; Browning, P.J. ; Neipel, F. ; Biberfeld, P. ; Ensoli, B.

Human herpesvirus-8 (HHV-8) gene expression in Kaposi's sarcoma (KS) primary lesions: an in situ hybridization study.

Leukemia 13 (Suppl.1), 110-112 (1999)

Stürzl, M. ; Ensoli, B.

Big but weak: How many pathogenic genes does human herpesvirus-8 need to cause Kaposi's sarcoma ? (Review).

Int. J. Oncol. 14, 287-289 (1999)

Hohenadl, C. ; Germaier, H. ; Walchner, M. ; Hagenhofer, M. ; Hermann, M. ; Stürzl, M. ; Kind, P. ; Hehlmann, R. ; Erfle, V. ; Leib-Mösch, C.

Transcriptional Activation of Endogenous Retroviral Sequences in Human Epidermal Keratinocytes by UVB Irradiation.

J. Invest. Dermatol. 113, 587-594 (1999)

Ludwig, E. ; Silberstein, F.C. ; van Empel, J. ; Erfle, V. ; Neumann, M. ; Brack-Werner, R.

Diminished rev-mediated stimulation of human immunodeficiency virus type 1 protein synthesis is a hallmark of human astrocytes.

J. Virol. 73, 8279-8289 (1999)

Ambrosini, E. ; Ceccherini-Silberstein, F. ; Erfle, V. ; Aloisi, F. ; Levi, G.

Gene transfer in astrocytes: Comparison between different delivering methods and expression of the HIV-1 protein Nef.

J. Neurosci. Res. 55, 569-577 (1999)

Ascherl, G.

Molekularbiologische und zellbiologische Untersuchungen zur Rolle angiogener Wachstumsfaktoren und des HIV-1-Tat-Proteins in der AIDS-assoziierten Vaskulopathie.

München, Technische Universität, Fakultät für Chemie, Diss., 1999, 155 S.

Sutter, G.

Untersuchung von rekombinantem modifiziertem Vacciniavirus Ankara zur Entwicklung von Impfstoffen gegen Lentivirus-Infektionen.

1998, 1-155, Diss., 1998)

Forster, R. ; Kremmer, E. ; Schubel, A. ; Breitfeld, D. ; Kleinschmidt, A. ; Nerl, C. ; Bernhardt, G. ; Lipp, M.

Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusion on various leukocyte subset: Rapid internalization and recycling upon activation.

J. Immunol. 160, 152-1531 (1998)

Fleuchaus, A.G.

Rekombinante Modifizierte Vaccinia Ankara Viren zur Expression von SIV-Antigenen.

München, Ludwig-Maximilians-Universität, Fakultät für Biologie, Diss., 1998, 177 S.

Ludwig, E.

Modulation der Eigenschaften des HIV-1 Transaktivierungsfaktors Rev in menschlichen Astrozyten.

1998, 183 S. (Zugl. Fakultät f. Biologie, LMU-München, Diss., 1998)

Wachinger, M. ; Kleinschmidt, A. ; Winder, D. ; von Pechmann, N. ; Ludvigsen, A. ; Neumann, M. ; Holle, R. ; Salmons, B. ; Erfle, V. ; Brack-Werner, R.

Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression.

J. Gen. Virol. 79, 731-740 (1998)

Herrmann, G. ; Schön, A. ; Brack-Werner, R. ; Werner, T.

CONRAD: A method for identification of variable and conserved regions within proteins by scale-space filtering.

Bioinformatics 12, 197-203 (1996)

Mitreiter, K. ; Schmidt, J. ; Luz, A. ; Atkinson, M.J. ; Höfler, H.H. ; Erfle, V.F. ; Strauß, P.G.

Disruption of the murine p53 gene by insertion of an endogenous retrovirus-like element (ETn) in a cell line from radiation-induced osteosarcoma.

Virology 200, 837-841 (1994)

Kleinschmidt, A.M. ; Neumann, M.C. ; Möller, C. ; Erfle, V.F. ; Brack-Werner, R.

Restricted expression of HIV1 in human astrocytes: Molecular basis for viral persistence in the CNS.

Res. virol. 145, 147-153 (1994)

Salmons, B. ; Günzburg, W.H.

Targeting of Retroviral Vectors for Gene Therapy.

Hum. Gene Ther. 4, 129-141 (1993)

Strauss, P.G. ; Mitreiter, K. ; Zitzelsberger, H. ; Luz, A. ; Schmidt, J. ; Höfler, H. ; Erfle, V.

Inverse Correlation of p53 and Osteocalcin RNA Expression in Murine Osteosarcomas.

In: Novak, J.F.* ; McMaster, J.H.* [Eds.]: Frontiers of Osteosarcoma research. Seattle (u.a.) : Hogrefe & Huber Publishers, 1993. 289-292

Strauss, P.G. ; Schmidt, J. ; Luz, A. ; Erfle, V.

Radiation-induced Osteosarcoma: a Model for Evaluation of Molecular Pathways to Transformation.

In: Novak, J.F.* ; McMaster, J.H.* [Eds.]: Frontiers of Osteosarcoma Research. Seattle (u.a.) : Hogrefe & Huber Publishers, 1993. 411-418

von Brunn, A. ; Reichhuber, C. ; Brand, M. ; Bechowsky, B. ; Gürtler, L. ; Eberle, J. ; Kleinschmidt, A. ; Erfle, V. ; Schödel, F.

The Principal Neutralizing Determinant (V3) of HIV-1 Induces HIV-1-neutralizing Antibodies upon Expression on HBcAg Particles.

Vaccine 93 (1993)

von Dalnok, G.K. ; Kleinschmidt, A.M. ; Neumann, M.C. ; Leib-Moesch, C. ; Erfle, V.F. ; Brack-Werner, R.

Productive expression state confers resistance of human immunodeficiency virus (HIV)-2-infected lymphoma cells against superinfection by HIV-1.

Arch. Virol. 131, 419-429 (1993)

Siakkou, H. ; Jahn, S. ; Kienzle, N. ; Ulrich, R.G. ; Grötzinger, C. ; Schneider, T.H. ; Kohleisen, B. ; Pauli, G. ; Spohn, R. ; Jung, G. ; Müller-Lantzsch, N. ; Krüger, D.H.

Fine mapping of HIV-1 Nef-epitopes by monoclonal antibodies.

Arch. Virol. 128, 81-95 (1993)

Wachinger, M. ; Samtleben, R. ; Gerhäuser, C. ; Wagner, H. ; Erfle, V.F.

Bryodin, a single-chain ribosome-inactivating protein, selectively inhibits the growth of HIV-1-infected cells and reduces HIV-1 production.

Res. Exp. Med. 193, 1-12 (1993)

Salmons, B. ; Günzburg, W.H.

Targeting of retroviral vectors for gene therapy.

Hum. Gene Ther. 4, 129-141 (1993)

Kohleisen, B. ; Gaedigk-Nitschko, K. ; Werner, T. ; Görblich, T. ; Herrmann, R. ; Erfle, V.F. ; Brack-Werner, R.

Biological properties of Nef and its pathogenic potential in HIV-1 related central nervous system dysfunction.

AIDS-Forschung 8, 275-281 (1993)

Faff, O. ; Murray, B.A. ; Erfle, V.F. ; Hehlmann., R.

Large scale production and purification of human retrovirus-like particles related to the mouse mammary tumor virus.

FEMS Microbiol. Lett. 109, 289-296 (1993)

Günzburg, W.H. ; Heinemann, F. ; Wintersperger, S. ; Miethke, T. ; Wagner, H.M. ; Erfle, V.F. ; Salmons, B.

Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat.

Nature 364, 154-158 (1993)

Willer, A.M. ; Heinzmann, U. ; Mellert, W. ; Kleinschmidt, A.M. ; Goebel -, F.D. ; Erfle, V.F.

Reduction of HIV-1 antigen production by phosphatidylcholine containing formulations via growth inhibition of HIV-1-infected cells.

Res. Exp. Med. 193, 123-135 (1993)

Leib-Mösch, C. ; Haltmeier, M. ; Werner, T. ; Geigl, E.M. ; Brack-Werner, R. ; Francke., U. ; Erfle, V.F. ; Hehlmann., R.

Genomic distribution and transcription of solitary HERV-K LTRs.

Genomics 18, 261-269 (1993)

Günzburg, W.H. ; Salmons, B.

Factors Controlling the Expression of Mouse Mammary Tumour Virus.

Biochem. J. 283, 625-632 (1992)

Goralczyk, R. ; Luz, A. ; Erfle, V. ; Schmidt, J.

Metastatic Growth of v-fos-induced Osteosarcoma, Following in Vitro Cultivation.

Zbl. Pathol. 138, 97-102 (1992)

Wachinger, G. ; Nitschko, H. ; Wachinger, M. ; von der Helm, K.

The p17 Stretch at the N Terminus of the HIV1-gag Precursor and the Intracellular Part of HIV1- env gp41 have heptad Repeat Regions in their Sequences that Could Bind to Each other in a Coild Coil.

Protein Sequ. Data Anal. 4, 375-376 (1992)

Faff, O. ; Murray, A.B. ; Schmidt, J. ; Leib-Mösch, C. ; Erfle, V. ; Hehlmann, R.

Retrovirus-like Particles from the hum T47D Cell Line are Related to Mouse Mmary Tumour Virus and are of Human Endogenous Origin.

J. Gen. Virol. 73, 1087-1097 (1992)

Erfle, V. ; Kohleisen, B. ; Gaedigk-Nitschko, K. ; Kleinschmidt, A. ; Werner, T. ; Neumann, M. ; Ludvigsen, A. ; Herrmann, R. ; Görblich, T. ; Brack-Werner, R.

Infection of the Central Nervous System by HIV-1: Target Cells and Mechanism of Viral Replication.

In: Weis, S.* ; Hippius, H.* [Eds.]: HIV-1 Infection of the Central Nervous System. Clinical, Pathological, and Molecular Aspects. Seattle : Hogrefe & Huber Publ., 1992. 281-305

Schätzl, H. ; Yakovleva, L. ; Lapin, B. ; Rose, D. ; Inzhiia, L. ; Gaedigk-Nitschko, K. ; Deinhardt, F. ; von der Helm, K.

Detection and Characterization of T-Cell Leukemia Virus-Like Proviral Sequences in PBL and Tissues of Baboons by PCR.

Leukemia 6 (Suppl.3), 158-160 (1992)

Kohleisen, B. ; Neumann, M.C. ; Herrmann, R. ; Brack-Werner, R. ; Krohn, K.J.E. ; Ovod, V.V. ; Ranki, A.M. ; Erfle, V.F.

Cellular localization of Nef expressed in persistently HIV-1-infected low-producer astrocytes.

Aids 6, 1427-1436 (1992)

Wachinger, M. ; Særmark, T. ; Erfle, V.F.

Influence of amphipathic peptides on the HIV-1 production in persistently infected T lymphoma cells.

FEBS Lett. 309, 235-241 (1992)

Strauß, P.G. ; Mitreiter, K. ; Zitzelsberger, H. ; Luz, A. ; Schmidt, J. ; Erfle, V.F. ; Höfler, H.

Elevated p53 RNA expression correlates with incomplete osteogenic differentiation of radiation-induced murine osteosarcomas.

Int. J. Cancer 50, 252-258 (1992)

Brack-Werner, R. ; Kleinschmidt, A.M. ; Ludvigsen, A. ; Mellert, W. ; Neumann, M.C. ; Herrmann, R. ; Khim, M.C.L. ; Burny, A. ; Müller-Lantzsch, N. ; Stavrou, D.K. ; Erfle, V.F.

Infection of human brain cells by HIV-1: Restricted virus production in chronically infected human glial cell lines.

Aids 6, 273-285 (1992)

Leib-Mösch, C. ; Bachmann, M. ; Brack-Werner, R. ; Werner, T. ; Erfle, V.F. ; Hehlmann., R.

Expression and biological significance of human endogenous retroviral sequences.

Leukemia 6, 72S-75S (1992)

Werner, T. ; Ferroni, S. ; Særmark, T. ; Brack-Werner, R. ; Banati, R.B. ; Mager, R. ; Steinaa, L. ; Kreutzberg, G.W. ; Erfle, V.F.

HIV-1 Nef protein exhibits structural and functional similarity to scorpion peptides interacting with K+ channels.

Aids 5, 1301-1308 (1991)

Leib-Mösch, C. ; Brack-Werner, R. ; Werner, T. ; Bachmann, M. ; Faff, O. ; Erfle, V.F. ; Hehlmann., R.

Endogenous retroviral elements in human DNA.

Cancer Res. 50, 17, 5636s-5642s (1990)

Günzburg, W.H. ; Erfle, V.