HIV immune activation and morphogenesis

2015

Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. (2015) HIV-1 Nef and Vpu interfere with L-selection (CD62L) cell surface expression to inhibit adhesion and signalling in infected CD4+ T lymphocytes. J. Virol. Accepted manuscript posted online 11 March 2015 , doi:10.1128/JVI.00611-15.


Lambelé M, Koppensteiner H, Symeonides M, Roy NH, Chan J, Schindler M, Thali M. (2015) Vpu Is the Main Determinant for Tetraspanin Downregulation in HIV-1-Infected Cells. J Virol. 2015 Mar 15;89(6):3247-55.

2014

Nehls J, Koppensteiner H, Brack-Werner R, Floss T, Schindler M. (2014) HIV-1 Replication in Human Immune Cells Is Independent of TAR DNA Binding Protein 43 (TDP-43) Expression. PLoS One. 2014 Aug 15;9(8):e105478

Bolduan S, Reif T, Schindler M*, Schubert U*. (2014) HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain. Virology. 2014 Sep;464-465C:375-384. *Equal last authors

Hagen N, Bayer K, Rösch K, Schindler M. (2014) The intraviral protein interaction network of hepatitis C virus. Mol Cell Proteomics. 2014 Jul;13(7):1676-89.

Gnirß K, Fiedler M, Krämer-Kühl A, Bolduan S, Mittler E, Becker S, Schindler M, Pöhlmann S. (2014) Analysis of determinants in filovirus glycoproteins required for tetherin antagonism. Viruses. 2014 Apr 9;6(4):1654-71.

Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. (2014) Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014 Mar 14;343(6176):1221-8.

Helfer M, Koppensteiner H, Schneider M, Rebensburg S, Forcisi S, Müller C, Schmitt-Kopplin P, Schindler M, Brack-Werner R. (2014) The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor. PLoS One. 2014 Jan 29;9(1):e87487.

Koppensteiner H, Höhne K, Gondim MV, Gobert FX, Widder M, Gundlach S, Heigele A, Kirchhoff F, Winkler M, Benaroch P, Schindler M. (2014) Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis. Retrovirology. 2014 Jan 2;11:1.

 

2013

Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, Kirchhoff F (2013) Verhasselt B. Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms. Retrovirology. 2013 Nov 15;10:137.

Gaudin R, Berre S, Cunha de Alencar B, Decalf J, Schindler M, Gobert FX, Jouve M, Benaroch P. (2013) Dynamics of HIV-Containing Compartments in Macrophages Reveal Sequestration of Virions and Transient Surface Connections. PLoS One. 2013 Jul 29;8(7):e69450. doi: 10.1371/journal.pone.0069450.

Bolduan S, Hubel P, Reif T, Hoehne K, Fritz J, Sauter D, Kirchhoff F, Fackler OT, Schindler M, Schubert U. (2013) HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A. Virology, 2013 Jun 5;440(2):190-203. doi: 10.1016/j.virol.2013.02.021. Epub 2013 Mar 22.

2012

  • Koppensteiner H, Banning C, Schneider C, Hohenberg H, Schindler M. (2012) Macrophage Internal HIV-1 Is Protected from Neutralizing Antibodies. J Virol. 2012 Mar;86(5):2826-36. Epub 2011 Dec 28
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  • Gaudin R, Cunha de Alencar B, Jouve M, Bèrre S, Le Bouder E, Schindler M, Varthaman A, Gobert FX, Benaroch P. (2012) Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages. J Cell Biol. 2012 Oct 22. [Epub ahead of print]
  • Koppensteiner H, Brack-Werner R, Schindler M. (2012) Macrophages and their Relevance in Human Immunodeficiency Virus Type I Infection. Retrovirology, 2012, 9:82
  • Hoffmann D, Schwarck D, Banning C, Brenner M, Mariyanna L, Krepstakies M, Schindler M, Millar DP, Hauber J. (2012) Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains. PLoS One. 2012;7(6):e38305.

2011

  • Kühl A, Banning C, Marzi A, Votteler J, Steffen I, Bertram S, Glowacka I, Konrad A, Stürzl M, Guo JT, Schubert U, Feldmann H, Behrens G, Schindler M, Pöhlmann S. (2011) The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin. J Infect Dis. 2011 Nov;204 Suppl 3:S850-60
  • Stieler K, Schindler S, Schlomm T, Hohn O, Bannert N, Simon R, Minner S, Schindler M, Fischer N (2011) No Detection of XMRV in Blood Samples and Tissue Sections from Prostate Cancer Patients in Northern Europe. PLoS One. 2011;6(10):e25592. Epub 2011 Oct 12
  • Bolduan S, Votteler J, Lodermeyer V, Greiner T, Koppensteiner H, Schindler M, Thiel G, Schubert U. (2011) Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317. Virology. 2011 Jul 20;416(1-2):75-85. Epub 2011 May 23
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  • Koppensteiner H, Banning C, Schneider C, Hohenberg H, Schindler M. (2012) Macrophage Internal HIV-1 Is Protected from Neutralizing Antibodies. J Virol. 2012 Mar;86(5):2826-36. Epub 2011 Dec 28
  • Ghiglione Y, Rodríguez AM, De Candia C, Carobene M, Benaroch P, Schindler M, Salomón H, Turk G (2011) HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects. Virus Res. 2011 Sep 16.
  • Stieler K, Schindler S, Schlomm T, Hohn O, Bannert N, Simon R, Minner S, Schindler M, Fischer N (2011) No Detection of XMRV in Blood Samples and Tissue Sections from Prostate Cancer Patients in Northern Europe. PLoS One. 2011;6(10):e25592. Epub 2011 Oct 12.
  • Heigele A, Schindler M, Gnanadurai CW, Leonard JA, Collins KL, Kirchhoff (2011) F.Down-modulation of CD8{alpha}ss is a fundamental activity of primate lentiviral Nef proteins. J Virol. 2011 Oct 19. [Epub ahead of print]
  • Tschulena U, Sanzenbacher R, Mühlebach MD, Berger A, Münch J, Schindler M, Kirchhoff F, Plesker R, Coulibaly C, Panitz S, Prüfer S, Muckenfuss H, Hamdorf M, Schweizer M, Cichutek K, Flory E. (2011) Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease. Retrovirology. 2011 Mar 2;8:14.
  • Schmökel J, Sauter D, Schindler M, Leendertz FH, Bailes E, Dazza MC, Saragosti S, Bibollet-Ruche F, Peeters M, Hahn BH, Kirchhoff F. (2011) The presence of a vpu gene and lack of Nef-mediated down-modulation of TCR-CD3 are not always linked in primate lentiviruses. J Virol. 2011 Jan;85(2):742-52. Epub 2010 Nov 10.

2010

  • Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, Kirchhoff F, Schubert U, Hauber J, Schindler M. (2010) A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells. PLoS ONE 5(2): e9344. doi:10.1371/journal.pone.0009344
  • Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T and Kirchhoff F. (2010) Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. Retrovirology 2010, 7:1doi:10.1186/1742-4690-7-1
  • Benaroch P, Billard E, Gaudin R, Schindler M, Jouve M. (2010) HIV-1 assembly in macrophages. Retrovirology, 2010 Apr 7;7:29.

2009

  • Sauter D,* Schindler M,* Specht A,* Landford W, Munch J, Kim KA, Votteler J, Schubert U, Bibollet-Ruche F, Keele BF, Takehisa J, Ogando Y, Ochsenbauer C, Kappes JC, Ayouba A, Peeters M, Learn GH, Shaw G, Sharp PM, Bieniasz P, Hahn BH, Hatziioannou T, Kirchhoff F. (2009) Tetherin-Driven Adaptation of Vpu and Nef Function during the Evolution of Pandemic and Nonpandemic HIV-1 strain. Cell Host&Microbe 2009, Nov 19;6(5):409-21. *Equal contribution
  • Rudolph JM, Eickel N, Haller C, Schindler M, Fackler OT. (2009) Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins. J Virol. 2009 Nov;83(22):11528-39
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  • Schmokel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, Kirchhoff F. Conservation of Nef function across highly diverse lineages of SIVsmm. Retrovirology. 2009 Apr 9;6(1):36.
  • Turk G, Gundlach S, Carobene M, Schindler M, Salomon H, Benaroch P. Single Nef proteins from HIV type 1 subtypes C and F fail to upregulate invariant chain cell surface expression but are active for other functions. AIDS Res Hum Retroviruses. 2009 Mar;25(3):285-96.

2008

  • Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalod M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F. (2008) Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+ T cells in natural SIV infection. PLoS Pathog 4(7): e1000107. doi:10.1371/journal.ppat. 1000107
  • Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J. (2008) Role of Nef in primate lentiviral immunopathogenesis. Cell Mol Life Sci. 2008 Sep;65(17):2621-36. 2008 Apr 26. [Epub ahead of print].
  • Toussaint H, Gobert FX, Schindler M, Banning C, Kozik Patrycja, Jouve M, Kirchhoff F, Benaroch P. (2008) HIV-1 Nef expression prevents AP-2-mediated internalization of the MHC II-associated invariant chain. J Virol. 2008 Sep;82(17):8373-82. Epub 2008 Jul 2.
  • Specht A, Degottardi MQ, Schindler M, Hahn B, Evans DT, Kirchhoff F. (2008) Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses. Virology. 2008 Mar 30;373(1):229-37. Epub 2007 Dec 21.

2007

  • Schindler, M., Wildum, S., Casartelli, N., Doria, M. and Kirchhoff, F. (2007) Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progressors. AIDS. May 31;21(9):1103-7
  • Münch, J., Ständker, L., Adermann, K., Schulz, A., Schindler, M., Chinnadurai, R., Pöhlmann, S., Chaipan, C., Biet, T., Peters, T., Meyer, B., Wilhelm, D., Lu, H., Jing, W., Jiang, S., Forssmann, WG., Kirchhoff, F. (2007) Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell. Apr 20;129(2):263-75
  • Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F. (2007) Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection. Cell. Dec 14;131(6):1059-71.
  • Münch J,* Rajan D,* Schindler M,* Specht A,* Rücker E, Novembre FJ, Nerrienet E, Müller-Trutwin MC, Peeters M, Hahn BH, Kirchhoff F. (2007) Nef-mediated Enhancement of Virion Infectivity and Stimulation of Viral Replication are Fundamental Properties of Primate Lentiviruses. J Virol. 2007 Dec;81(24):13852-64. Epub 2007 Oct 10. *Equal contribution 
  • Schindler M, Rajan D, Specht A, Ritter C, Pulkkinen K, Saksela K, Kirchhoff F. (2007) Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue. J Virol. Dec;81(23):13005-14. Epub 2007 Sep 19.
  • Priceputu, E., Hanna, Z., Simard MC., Vincent, P., Hu, C., Wildum S., Schindler M., Kirchhoff, F., Jolicoeur. P. (2007) Primary HIV-1 Nef Alleles Show Major Differences in Pathogenicity in Transgenic Mice. J Virol. 2007 May;81(9):4677-93. Epub 2007 Feb 21.

2006

  • Schindler, M., Münch, J., Kutsch, O., Li, H., Santiago, M., Bibollet-Ruche, F., Müller-Trutwin, M., Novembre, F., Peeters, M., Courgnaud, V., Bailes, E., Roques, P., Sodora, D., Silvestri, G., Sharp, P., Hahn, B., Kirchhoff, F., (2006) Nef-mediated suppression of T cell activation is a fundamental property of primate lentiviruses. Cell 125: 1055-67
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  • Wildum, S., Schindler, M., Munch, J., Kirchhoff, F. (2006) Contribution of Vpu, Env and Nef to CD4 down-modulation and resistance of HIV-1 infected T-cells to superinfection. J Virol. 80: 8047-59.
  • Brenner, M., Münch, J., Schindler, M., Wildum, S., Stolte, N., Stahl-Hennig, C., Fuchs, D., Mätz-Rensing, K., Franz, M., Heeney, J., Ten Haaft, P., Swigut, T., Hrecka, K., Skowronski, J., Kirchhoff, F. (2006) Importance of the N-distal AP-2 binding element in Nef for Simian Immunodeficiency Virus replication and pathogenicity in rhesus macaques. J Virol. 80: 4469-81.
  • Rajan, D., Wildum, S., Rucker, E., Schindler, M., Kirchhoff, F. (2006) Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo. AIDS 20: 831-6.

2001 - 2005

  • Hrecka, K., Swigut, T., Schindler, M., Kirchhoff, F., Skowronski, J. (2005) Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. J Virol. 79:10650-9.
  • Münch, J.,* Schindler, M.,* Wildum, S., Rucker, E., Bailer, N., Knoop, V., Novembre, F.J., and Kirchhoff, F. (2005). Primary SIVsm and HIV-2 Nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication. J. Virol. 79: 10547-10560. *Equal contribution
  • van 't Wout, A.B., Swain, J.V., Schindler, M., Rao, U., Pathmajeyan, M.S., Mullins, J.I., Kirchhoff, F. (2005). Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. J. Virol. 79: 10053-8.
  • Schindler, M., Münch, J., Kirchhoff, F. (2005). HIV-1 inhibits DNA damage triggered apoptosis by a Nef-independent mechanism. J. Virol. 79: 5489-5498.
  • Schindler, M., Munch, J., Brenner, M., Stahl-Hennig, C., Skowronski, J. & Kirchhoff, F. (2004). Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques. J.Virol. 78: 10588-10597.
  • Kirchhoff, F., Schindler, M., Bailer, N., Renkema, G.H., Saksela, K., Knoop, V., Muller-Trutwin, M.C., Santiago, M.L., Bibollet-Ruche, F., Dittmar, M.T., Heeney, J.L., Hahn, B.H., Münch J. (2004). Nef proteins from SIVcpz-infected Chimpanzees and HIV-1 group N and O -infected Humans Interact with the p21-activated Kinase 2 and Modulate Cell Surface Expression of Various Human Receptors. J. Virol. 78: 6864- 6874.
  • Hiebenthal-Millow, K., Greenough, T.C., Bretttler, D.B., Schindler, M., Wildum, S., Sullivan, J.L., Kirchhoff, F. (2003) Alterations in HIV-1 LTR promoter activity during AIDS progression. Virology 317: 109-18.
  • Schindler, M., Wurfl, S., Benaroch, P., Greenough, T. C., Daniels, R., Easterbrook, P., Brenner, M., Munch, J., Kirchhoff, F. (2003). Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J.Virol. 77: 10548-10556.
  • Arganaraz, E.R., Schindler, M., Kirchhoff, F., Cortes, M.J., Lama, J. (2003) Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem. 278: 33912-9.
  • Pruchner, D., Nassal, B., Schindler, M., Knoop, V. (2001) Mosses share mitochondrial group II introns with flowering plants, not with liverworts. Mol Genet Genomics. 266: 608-13.

Others

  • Schindler M, Banning C (2010), Analyse von Proteininteraktionen durch FRET und FACS. Biospektrum 03/2010
  • Banning, C., Schindler, M. (2010). Mit FRET und FACS auf Partnersuche. Laborjournal 04/2010
  • Schindler M, Banning C, Holstermann B, Hohenberg H. (2009). Virologische Fährtensuche: Kombinierte Mikroskopietechniken zur Abbildung von Virusinfektionen. Bioforum 03/2009 S31-33.
  • Schindler M. (2008) Evolution des lentiviralen Nef Proteins. VDM-Verlag 2008 May, ISBN 978-3-639-01822-6
  • Schindler M, Kirchhoff F (2006) AIDS – Ein Unfall der viralen Evolution? Retrovirus Bulletin 04/2006