Inflammation induced tissue damage

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Recent publications

    • Jörs S., Jeliazkova P., Ringelhan M., Thalhammer J., Dürl S., Ferrer J., Sander M., Heikenwälder M., Schmid RM., Siveke JT., Geisler F., Lineage fate of ductular reactions in liver injury and carcinogenesis. J Clin Invest. 27, doi: 10.1172/JCI78585 (2015)

    • Goldmann T., Zeller N., Raasch J., Kierdorf K., Frenzel K., Ketscher L., Basters A., Staszewski O., Brendecke SM., Spiess A., Tay TL., Kreutz C., Timmer J., Mancini GM., BlankT., Fritz G., Biber K., Lang R., Malo D., Merkler D., Heikenwälder M., Knobeloch KP., Prinz M., USP18 lack in microglia causes destructive interferonopathy of the mouse brain. EMBO J. 20, pii: e201490791 (2015)

    • O Connor T., Borsig L., Heikenwälder M., CCL2-CCR2 signaling in disease pathogenesis. Endocr Metab Immune Disord Drug Targets. 16 (2015)

    • Liver cancer: future scientific and clinical challenges and forthcoming problems in Europe. Mathias Heikenwälder; Adjacent Digital Politics Limited (2015)

    • Boettcher, S., Gerosa, R., Radpour, R., Bauer, J., Ampenberger, F., Heikenwälder, M., Kopf, M., Manz, M.G. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood 124, 1393-1403 (2014)

    • Eisele, Y.S., Fritschi, S.K., Hamaguchi, T., Obermüller, U., Füger, P., Skodras, A., Schäfer, C., Odenthal, J., Heikenwälder, M., Staufenbiel, M., Jucker, M. Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis. J. Neurosci. 34, 10264-10273 (2014)

    • Friemel, J., Rechsteiner, M.P., Frick, L., Boehm, F., Struckmann, K., Sigg, M., Moch, H., Heikenwälder, M., Weber, A. Intratumor heterogeneity in hepatocellular carcinoma. Clin. Cancer Res., DOI: 10.1158/1078-0432.CCR-14-0122 (2014)

    • Gautheron, J., Vucur, M., Reisinger, F., Cardenas, D.V., Roderburg, C., Koppe, C., Kreggenwinkel, K., Schneider, A.T., Bartneck, M., Neumann, U.P., Canbay, A., Reeves, H.L., Luedde, M., Tacke, F., Trautwein, C., Heikenwälder, M., Luedde, T. A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol. Med. 6, 1062-1074 (2014)

    • Gewies, A., Gorka, O., Bergmann, H., Pechloff, K., Petermann, F., Jeltsch, K.M., Rudelius, M., Kriegsmann, M., Weichert, W., Horsch, M., Beckers, J., Wurst, W., Heikenwälder, M., Korn, T., Heissmeyer, V., Ruland, J. Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Reports 9, 1292-1305 (2014)

    • Heikenwälder, M., Protzer, U. LINE(1)s of evidence in HBV-driven liver cancer. Cell Host Microbe 15, 249-250 (2014)

    • Hösel, M., Lucifora, J., Michler, T., Holz, G., Gruffaz, M., Stahnke, S., Zoulim, F., Durantel, D., Heikenwälder, M., Nierhoff, D., Millet, R., Salvetti, A., Protzer, U., Buning, H. Hepatitis B virus infection enhances susceptibility towards adeno-associated viral vector transduction in vitro and in vivo. Hepatology 59, 2110-2120 (2014)

    • Lucifora, J., Xia, Y., Reisinger, F., Stadler, D., Heikenwälder, M., Protzer, U. Dégradation spécifique de l´ADN nucléaire responsable de la persistance du virus de l´hépatite B. Med. Sci. (Paris) 30, 724-726 (2014)

    • Ringelhan, M., Protzer, U., O'Connor, T., Heikenwälder, M. The direct and indirect role of HBV in liver cancer: Prospective markers for HCC-screening and potential therapeutic targets. J. Pathol. 235, 355-367 (2015) [published online 2014]

    • Rothhammer, V., Muschaweckh, A., Gasteiger, G., Petermann, F., Heink, S., Busch, D., Heikenwälder, M., Hemmer, B., Drexler, I., Korn, T. α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets. Acta Neuropathol. Commun. 2:27 (2014)

    • Schölzel, K., Schildberg, F.A., Welz, M., Borner, C., Geiger, S., Kurts, C., Heikenwälder, M., Knolle, P.A., Wohlleber, D. Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J. Hepatol. 61, 600-608 (2014)
    • Seleznik, G.M., Zöller, J., O'Connor, T., Graf, R., Heikenwälder, M. The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies. Cytokine Growth Factor Rev. 25, 125-137 (2014)

    • Seubert, B., Cui, H., Simonavicius, N., Honert, K., Schafer, S., Reuning, U., Heikenwälder, M., Mari, B., Krüger, A. Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization. Int. J. Cancer 136, 2304-2315 (2015) [published online 2014]

    • Seubert, B., Grünwald, B., Kobuch, J., Cui, H., Schelter, F., Schaten, S., Siveke, J.T., Lim, N.H., Nagase, H., Simonavicius, N., Heikenwälder, M., Reinheckel, T., Sleeman, J.P., Janssen, K.P., Knolle, P.A., Krüger, A. TIMP-1 creates a pre-metastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology 61, 238-248 (2015) [published online 2014]

    • Sprinzl, M.F., Puschnik, A., Schlitter, A.M., Schad, A., Ackermann, K., Esposito, I., Lang, H., Galle, P.R., Weinmann, A., Heikenwälder, M., Protzer, U. Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. J. Hepatol., DOI: 10.1016/j.jhep.2014.11.011 (2014)

    • Unger, K., Heikenwälder, M. Analysis of chromosomal aberrations in murine HCC. Methods Mol. Biol. 1193, 213-226 (2014)

    • Waldschmitt, N., Berger, E., Rath, E., Sartor, R.B., Weigmann, B., Heikenwälder, M., Gerhard, M., Janssen, K.P., Haller, D. C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation. Mucosal Immunol. 7, 1452-1466 (2014)

    • Wolf, M.J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., Lorentzen, A.R., Einer, C., Schulz, S., Clavel, T., Protzer, U., Thiele, C., Zischka, H., Moch, H., Tschöp, M.H., Tumanov, A.V., Haller, D., Unger, K., Karin, M., Kopf, M., Knolle, P., Weber, A., Heikenwälder, M. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26, 549-564 (2014)

    • Xia, Y.Effector pathway of the antiviral effect of interferons in Hepatitis B Virus infection. München, Technische Universität, Fakultät für Medizin, Diss., 2013, 151 S.

    • Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C.J., Damgaard, R.B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, M., Jost, P.J. XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation. Cell Reports 7, 1796-1808 (2014)
    • Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation. Nature Immunology 2014 Nov;15(11):1079-89.
    • Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Ollinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A. A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nature Genetics. 2014 Dec 8. doi: 10.1038/ng.3164. [Epub ahead of print]

    • Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M, Protzer U.  Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. J Hepatol. 2014 Nov 22. pii: S0168-8278(14)00855-1.

    • Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J. Uncoupling malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep. 2014 Nov 20;9(4):1292-305.

    • Ringelhan M, Reisinger F, Yuan D, Weber A, Heikenwalder M. Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation. Curr Protoc Pharmacol. 2014 Dec 1;67:14.31.1-14.31.17..

    • Rothhammer V, Muschaweckh A, Gasteiger G, Petermann F, Heink S, Busch DH, Heikenwälder M, Hemmer B, Drexler I, Korn T Beta4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets. Acta Neuropathol Commun. 2014;2: 27
    • Boettcher S, Gerosa RC, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz MG Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood. 2014;124(9): 1393-403

    • Wyler L, Napoli CU, Ingold B, Sulser T, Heikenwälder M, Schraml P, Moch H Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression. Br J Cancer. 2014;110(3): 686-94

    • Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes. Cancer Cell. 2014;26(4): 549-64

    • Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Cardiovasc Res. 2014;103(2): 206-16

    • Heikenwalder M, Protzer U LINE(1)s of Evidence in HBV-Driven Liver Cancer. Cell Host Microbe. 2014;15(3): 249-50

    • Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation. Cell Rep. 2014;7(6): 1796-808

    • Seleznik GM, Zoller J, O'Connor T, Graf R, Heikenwalder M The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies. Cytokine Growth Factor Rev. 2014;25(2): 125-37
    • Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol Med. 2014;6(8): 1062-74

    • Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwalder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Krüger A Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology. 2014; Aug 18. doi: 10.1002/hep.27378.

    • Hösel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, Büning H Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo. Hepatology. 2014;59(6): 2110-20

    • Seubert B, Cui H, Simonavicius N, Honert K, Schäfer S, Reuning U, Heikenwalder M, Mari B, Krüger A Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization. Int J Cancer. 2014; Oct 29. doi: 10.1002/ijc.29296.

    • Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M, Protzer U Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. J Hepatol. 2014; Nov 22. pii: S0168-8278(14)00855-1.

    • Lucifora J, Xia Y, Reisinger F, Stadler D, Heikenwälder M, Protzer U [Specific degradation of nuclear hepatitis B virus covalently closed circular DNA]. Med Sci (Paris). 2014;30(8-9): 724-6

    • Protzer U, Böhm F, Longerich T, Seebach J, Heidary Navid M, Friemel J, Marques-Maggio E, Bawohl M, Heikenwalder M, Schirmacher P, Dutkowski P, Clavien PA, Schemmer P, Schnitzler P, Gotthardt D, Müllhaupt B, Weber A Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation. Mod Pathol. 2014;

    • Borsig L, Wolf MJ, Roblek M, Lorentzen A, Heikenwalder M Inflammatory chemokines and metastasis--tracing the accessory.Oncogene. 2014;33(25): 3217-24
    • Franceschi V, Stellari FF, Mangia C, Jacca S, Lavrentiadou S, Cavirani S, Heikenwalder M, Donofrio G. In vivo image analysis of BoHV-4-based vector in mice. PLoS ONE. 2014;9(4): e95779

    • Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U.Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014;343(6176): 1221-8

    • Xia Y, Lucifora J, Reisinger F, Heikenwalder M, Protzer U Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA". Science. 2014;344(6189): 1237

    • Wyler L, Napoli CU, Ingold B, Sulser T, Heikenwälder M, Schraml P, Moch H.
      Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.
      Br J Cancer. 2013 Dec 10. doi: 10.1038/bjc.2013.755. [Epub ahead of print]

    • Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA.
      Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis.
      Science. 2013 Dec 6;342(6163):1243-6. doi: 10.1126/science.1243364.

    • Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszewski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M
      Novel microglia gene targeting reveals a pivotal role of tak1 for autoimmune inflammation of the central nervous system
      Nat Neurosci. 2013 Nov;16(11):1618-26. doi: 10.1038/nn.3531. Epub 2013 Sep 29

    • Felmy B, Songhet P, Slack EM, Müller AJ, Kremer M, Van Maele L, Cayet D, Heikenwalder M, Sirard JC, Hardt WD.
      NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium
      PLoS One. 2013 Oct 15;8(10):e77204. doi: 10.1371/journal.pone.0077204.
      IF: 3,7

    • Ringelhan M, Heikenwalder M, Protzer U.
      Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development.
      Dig Dis. 2013;31(1):138-51. doi: 10.1159/000347209. Epub 2013 Jun 17. #

    • Understanding liver cancer development in Europe: Novel mouse models for pre-clinical trials.  Mathias Heikenwälder; Adjacent Digital Politics Limited (2013) 

    • Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U. T cells expressing a chimeric antigen receptor that binds hepatitis b virus envelope proteins control virus replication in mice

    • Gastroenterology. 2013 Aug;145(2):456-65. doi: 10.1053/j.gastro.2013.04.047. Epub 2013 Apr 30.

    •  Articles in Pan European Networks:

      • A burgeoning problem
        Mathias Heikenwälder
        Pan European Networks Science&Technology (2013)

      • Liver Cancer – A Future Challenge
        Mathias Heikenwälder
        Journal Pan European Networks Government (2013)
    • RIP3 Inhibits Inflammatory Hepatocarcinogenensis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation
      Mihael Vucur, Florian Reisinger, Jérémie Gautheron, Joern Janssen, Christoph Roderburg, David Vergas Cardenas, Karina Kreggenwinkel, Christiane Koppe, Linda Hammerich, Razq Hakern, Kristian Unger, Achim Weber, Nikolaus Gassler, Mark Luedde, Norbert Frey, Ulf Peter Neumann, Frank Tacke, Christian Trautwein, Mathias Heikenwälder and Tom Luedde
      Cell Rep. 2013 Aug. 29; 4(4): 776-90

    • Inflammatory chemokines and metastasis – tracing the accessory
      Lubor Borsig, Monika J. Wolf, Marko Roblek, Anna Lorentzen, Mathias Heikenwalder.
      Oncogene, 2013 Jul 15. DOI: 10.1038/one. 2013.272.

    • Intrahepatic myeloid cell-aggregates enable local CD8+ T cell expansion and successful immunotherapy against chronic viral liver infection
      Huang, L.R., Wohlleber, D., P., Reisinger, F., Kurts, C., Protzer, U., Heikenwalder, M., Knolle, P.A.
      Nature Immunology, 2013 Jun; 14(6):574-83.

    • Pathways of metastasizing intestinal cancer cells revealed: How will fighting metastases at the site of cancer cell arrest affect drug development?
      Mathias Heikenwalder and Lubor Borsig.
      Future Oncology, 2013 Jun; 9(1):1-4.

    • Microglia emerge from erythro-myeloid precursors via PU.1 and IRF-8 dependent pathways
      Katrin Kierdorf, Daniel Erny, Tobias Goldmann, Victor Sander, Christian Schulz, Elisa Gomez Perdiguero, Peter Wieghofer, Annette Heinrich, Pia Riemke, Christoph Hölscher, Dominik N. Müller, Bruno Luckow, Thomas Brocker, Katharina Debowski, Günter Fritz, Ghislain Opdenakker, Andreas Diefenbach, Knut Biber, Mathias Heikenwalder, Frederic Geissmann, Frank Rosenbauer and Marco Prinz.
      Nature Neuroscience, 2013 Mar; 16(3): 273-80

    • Combined loss of Rc3h1 and Rc3h2 derepresses Icos and Ox40 target mRNAs and imposes TFH differentiation on CD4 (+) T cells
      Katharina U. Vogel, Stephanie L. Edelmann, Katharina Jeltsch, Arianna Bertossi, Klaus Heger, Gitta A. Heinz, Jessica Zöller, Sebastian Warth, Kai P. Hoefig, Claudia Lohs, Frauke Neff, Elisabeth Kremmer, Joel Schick, Dirk Repsilber, Arie Geerlof, Helmut Blum, Wolfgang Wurst, Mathias Heikenwalder, Marc Schmidt-Supprian and Vigo Heissmeyer.
      Immunity, 2013 Apr 18; 38(4): 655-68

    • TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation
      Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA.
      Cell Rep. 2012 Sep 27; 1(3): 478-487

    • Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes
      O'Connor T, Frei N, Sponarova J, Schwarz P, Heikenwalder M, Aguzzi A.
      PLoS Pathog. 2012 Aug;8(8):e1002867. Epub 2012 Aug 9

    • Lymphotoxin ß Receptor Signaling Promotes Development of Autoimmune Pancreatitis
      Gitta M. Seleznik, Theresia Reding, Franziska Romrig, Yasuyuki Saito, Alexander Mildner, Stephan Segerer, Li-Kang Sun, Stephan Regenass, Maciej Lech, Hans- Joachim Anders, Donal McHugh, Teru Kumagi,Yoichi Hiasa,Carolin Lackner, Johannes Haybaeck, Eliane Angst, Aurel Perren, Maria Luisa Balmer, Emma Slack, Andrew MacPherson, Markus Manz, Achim Weber, Jeffrey L. Browning, Melek Canan Arkan, Thomas Rülicke, Adriano Aguzzi, Marco Prinz, Rolf Graf and Mathias Heikenwalder
      Gastroenterology  2012 Nov;143(5):1361-74

    • TLR3-expressing Tumor Parenchyma and Infiltrating NK Cells Promote Tumor Control in Hepatocellular Carcinoma Patients by Valerie Chew, Charlene Tow, Caleb Huang, Emilie Bard-Chapeau, Neal Copeland, Nancy Jenkins, Achim Weber, Kiat Hon Lim, Han Chong Toh, Mathias Heikenwalder, Irene Ng, Alessandra Nardin, and Jean-Pierre Abastado,
      The Journal of the National Cancer Institute

    • Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
      Monika Julia Wolf, Alexandra Hoos, Judith Bauer, Steffen Boettcher, Markus Knust, Achim Weber, Nicole Simonavicius, Christoph Schneider, Matthias Lang, Michael Stürzl, Roland S. Croner, Andreas Konrad, Markus Manz, Holger Moch, Adriano Aguzzi, Geert van Loo, Manolis Pasparakis, Marco Prinz, Lubor Borsig and Mathias Heikenwalder.
      Cancer Cell 2012 Jul 10;22(1):91-105

    • Follicular dendritic cells emerge from ubiquitous perivascular precursors
      Nike Julia Krautler, Veronika Kana, Jan Kranich, Yinghua Tian, Dushan Perera, Doreen Lemm, Petra Schwarz, Annika Armulik, Jeffrey L. Browning, Michelle Tallquist, Thorsten Buch, José B. Oliveira-Martins, Caihong Zhu, Mario Hermann, Ulrich Wagner, Robert Brink, Mathias Heikenwalder, Adriano Aguzzi.
      Cell 2012 Jul 6; 150(1):194-206

    • Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells.
      Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG.
      J Immunol. 2012 Jun 15;188(12):5824-8

    • Salmonella transiently reside in luminal neutrophils in the inflamed gut.
      Loetscher Y, Wieser A, Lengefeld J, Kaiser P, Schubert S, Heikenwalder M, Hardt WD, Stecher B.
      PLoS One. 2012;7(4):e34812. Epub 2012 Apr 6.

    • Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.
      Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T.
      Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6259-64. Epub 2012 Apr 2.

    • Transfer of HBV Genomes Using Low Doses of Adenovirus Vectors Leads to Persistent Infection in Immune Competent Mice.
      Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U.
      Gastroenterology. 2012 Jun; 142(7):1447-50.

    • „Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.“
      Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L.
      Nature. 2011 Nov 9. doi: 10.1038/nature10599. [Epub ahead of print]

    • Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by
      producing nitric oxide

      Stefanie Sieger, Hsin-Ying Huang, Chen-Ying Yang, Leonardo Scarpellino, Lucie Carrie, Sarah Essex, Peter J. Nelson, Mathias Heikenwalder, Hans Acha-Orbea, Christopher D.Buckley, Benjamin J. Marsland, Dietmar Zehn, Sanjiv A. Luther
      PLoS One, 11, 2011 Nov 9; 479(7374):547-51

    • The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis.
      Johannes Haybaeck, Nicolas Zeller and Mathias Heikenwalder.
      SMW  2011 Oct. 24; 141:w 13287

    • Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.
      Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP.
      Gut. 2011 Sep 19. [Epub ahead of print]

    • Chronic liver inflammation and hepatocellular carcinoma: persistence matters.
      Weber A, Boege YT, Reisinger F, Heikenwalder M.
      Swiss Med Wkly. 2011 May 10;141:w13197. doi: 10.4414/smw.2011.13197.

    • Secretagogin expression in the hippocampus and granule cell layer of dentate gyrus is reduced P301L tau mice. Johannes Attems, Kurt Jellinger, Roger Nitsch, Magdalena Maj, Ludwig Wagner and Mathias Heikenwalder.
      Journal of Neuronal Transmission, 2011 May;118(5):737-45.

    • COX-2 is not required for the development of murine chronic pancreatitis. Silva AB, Weber A, Bain M , Reding TV, Heikenwalder M, Sonda S, Graf R.
      Am J Physiol Gastrointest Liver Physiol. 2011 Mar 3. [Epub ahead of print]

    • Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture.
      Peters R, Wolf MJ, van den Broek M, Nuvolone M, Dannenmann S, Stieger B, Rapold R, Konrad D, Rubin A, Bertino JR, Aguzzi A, Heikenwalder M, Knuth AK.
      PLoS One. 2010 Dec 30;5(12):e15689.PMID: 21209896

    • Aerosols transmit prions to immunocompetent and immunodeficient mice            
      Mathias Heikenwalder *, Johannes Haybaeck *, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J. Fuchs, Lothar Stitz and Adriano Aguzzi.
      PLOS Pathog., 7(1): e1001257. doi:10.1371/journal.ppat.1001257

    • Peripherally Applied Ab-Containing Inoculates Induce Cerebral b-Amyloidosis.
      Eisele, Y., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S., Wolburg, H., Walker L., Staufenbiel, M., Heikenwalder, M., Jucker, M
      Science. 2010 Oct 21. [Epub ahead of print]

    • Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma?
      Vucur, M., Roderburg, C., Bettermann, K., Tacke, F., Heikenwalder, M., Trautwein, C. and Luedde, T.
      Oncotarget. 2010 Sep; 1(5):373-8.

    • The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea
      Endt K, Stecher B, Chaffron S, Slack E, Tchitchek N, Benecke A, Van Maele L, Sirard JC, Mueller AJ, Heikenwalder M, Macpherson AJ, Strugnell R, von Mering C, Hardt WD.
      PLoS Pathog. 2010 Sep 9;6(9). pii: e1001097.

    • Lymphotoxin’s link to carcinogenesis: Friend or Foe? From Lymphoid Neogenesis to Hepatocellular Carcinoma and Prostate Cancer.
      Wolf MJ, Seleznik GM and Heikenwalder M.
      Adv Exp Med Biol.
      2011;691:231-49.

    • The unexpected role of lymphotoxin signaling in carcinogenesis: From lymphoid neogenesis to liver and prostate cancer development
      Wolf M, Seleznik G, Zeller N and Heikenwalder M.
      Oncogene. 2010, 2010 Jul 5 [Epub ahead of print]

    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
      Hapfelmeier S, Lawson MA, Slack E, Kirundi JK, Stoel M, Heikenwalder M, Cahenzli J, Velykoredko Y, Balmer ML, Endt K, Geuking MB, Curtiss R 3rd, McCoy KD, Macpherson AJ.
      Science. 2010 Jun 25;328(5986):1705-9

    • TAK1 suppresses a NEMO-dependent, but NF-kB independent pathway to liver cancer
      Bettermann K, Vucur M, Koppe C, Heymann F, Haybaeck J, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, Akira S, Tacke F, Heikenwalder M, Trautwein C, and Luedde T.
      Cancer CELL. May 2010, 2010 May 18;17(5):481-96

    • Hepatocyte-specific deletion of Mcl-1 triggers proliferation and hepatocarcinogenesis in mice
      Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer P, Opferman J, Galle P, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H.
      Hepatology. 2009 Nov 30; DOI: 10.1002/hep.23479

    • A lymphotoxin-driven pathway to chronic hepatitis induced liver cancer
      Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Rolf Graf, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL,  Aguzzi A and Heikenwalder M.
      Cancer CELL. 2009 Oct 6;16(4):295-308

    • The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation
      Müller AJ, Hoffmann C, Galle M, Van Den Broeke A, Heikenwalder M, Falter L, Misselwitz B, Kremer M, Beyaert R, Hardt WD.
      CELL Host Microbe. 2009 Aug 20;6(2):125-36.PMID: 19683679

    • Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas
      Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A.
      Immunity. 2008 Dec 19;29(6):998-1008

    • Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology
      Heikenwalder M,* Baenziger S,* Johansen P, Schlaepfer E, Hofer U, Miller RC, Diemand S, Honda K, Kundig TM, Aguzzi A, Speck RF.
      Blood. 2009 Jan 8;113(2):377-88

    • Overexpression of lymphotoxin in T cells induces fulminant thymic involution
      Heikenwalder M,* Prinz M,* Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rülicke T, Macpherson AJ, Holländer GA, Nedospasov SA, Aguzzi A.
      American Journal of  Pathology. 2008 Jun; 172(6):1555-70

    • Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis
      Hapfelmeier S, Müller AJ, Stecher B, Kaiser P, Barthel M, Endt K, Eberhard M, Robbiani R, Jacobi CA, Heikenwalder M, Kirschning C, Jung S, Stallmach T, Kremer M, Hardt WD.
      Journal of  Experimental Medicine. 2008 Feb 18; 205(2):437-50. Epub 2008 Feb 11

    • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
      Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, Brück W, Priller J, Prinz M.
      Nature Neuroscience. 2007 Dec;10(12):1544-53

    • Germinal center B cells are dispensable in prion transport and neuroinvasion
      Heikenwalder M, Federau C, Boehmer L, Schwarz P, Wagner M, Zeller N, Haybaeck J, Prinz M, Becher B, Aguzzi A.
      J Neuroimmunol. 2007 Dec;192(1-2):113-23. Epub 2007 Oct 26

    • Early and rapid engraftment of bone marrow-derived microglia in scrapie
      Heikenwalder M, Priller J, Prinz M, Zeller N, Schwarz P, Heppner FL, Aguzzi A.
      J Neurosci. 2006 Nov 8;26(45):11753-62

    • Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-γC-/- mice
      Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF
      PNAS. 2006 Oct 24;103(43):15951-6. Epub 2006 Oct 12

    • Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
      Lang KS, Georgiev P, Recher M, Navarini AA, Bergthaler A, Heikenwalder M, Harris NL, Junt T, Odermatt B, Clavien PA, Pircher H, Akira S, Hengartner H, Zinkernagel RM.
      J Clin Invest. 2006 Sep;116(9):2456-63

      * contributed equally

    Selected publications

    • Willimsky G, Protzer U, Knolle P, Heikenwalder M.
      Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?
      Oncotarget. 2013 Jul 15. [Epub ahead of print] No abstract available

    • Huang, L.R., Wohlleber, D., P., Reisinger, F., Kurts, C., Protzer, U., Heikenwalder, M.°, Knolle, P.A.°Intrahepatic myeloid cell-aggregates enable local CD8+ T cell expansion and successful immunotherapy against chronic viral liver infection. Nature Immunology, in press (2013).
    • Microglia emerge from erythro-myeloid precursors via PU.1 and IRF-8 dependent pathways
      Katrin Kierdorf, Daniel Erny, Tobias Goldmann, Victor Sander, Christian Schulz, Elisa Gomez Perdiguero, Peter Wieghofer, Annette Heinrich, Pia Riemke, Christoph Hölscher, Dominik N. Müller, Bruno Luckow, Thomas Brocker, Katharina Debowski, Günter Fritz, Ghislain Opdenakker, Andreas Diefenbach, Knut Biber, Mathias Heikenwalder, Frederic Geissmann, Frank Rosenbauer and Marco Prinz. Nature Neuroscience, 2013 Mar; 16(3): 273-80
    • Combined loss of Rc3h1 and Rc3h2 derepresses Icos and Ox40 target mRNAs and imposes TFH differentiation on CD4 (+) T cells
      Katharina U. Vogel, Stephanie L. Edelmann, Katharina Jeltsch, Arianna Bertossi, Klaus Heger, Gitta A. Heinz, Jessica Zöller, Sebastian Warth, Kai P. Hoefig, Claudia Lohs, Frauke Neff, Elisabeth Kremmer, Joel Schick, Dirk Repsilber, Arie Geerlof, Helmut Blum, Wolfgang Wurst, Mathias Heikenwalder, Marc Schmidt-Supprian and Vigo Heissmeyer.
      Immunity, Jan. 2013 Apr 18; 38(4): 655-68
    • Lymphotoxin ß Receptor Signaling Promotes Development of Autoimmune Pancreatitis
      Gitta M. Seleznik, Theresia Reding, Franziska Romrig, Yasuyuki Saito, Alexander Mildner, Stephan Segerer, Li-Kang Sun, Stephan Regenass, Maciej Lech, Hans- Joachim Anders, Donal McHugh, Teru Kumagi,Yoichi Hiasa,Carolin Lackner, Johannes Haybaeck, Eliane Angst, Aurel Perren, Maria Luisa Balmer, Emma Slack, Andrew MacPherson, Markus Manz, Achim Weber, Jeffrey L. Browning, Melek Canan Arkan, Thomas Rülicke, Adriano Aguzzi, Marco Prinz, Rolf Graf and Mathias Heikenwalder
      Gastroenterology  2012 Nov;143(5):1361-74

    • TLR3-expressing Tumor Parenchyma and Infiltrating NK Cells Promote Tumor Control in Hepatocellular Carcinoma Patients by Valerie Chew, Charlene Tow, Caleb Huang, Emilie Bard-Chapeau, Neal Copeland, Nancy Jenkins, Achim Weber, Kiat Hon Lim, Han Chong Toh, Mathias Heikenwalder, Irene Ng, Alessandra Nardin, and Jean-Pierre Abastado,
      The Journal of the National Cancer Institute

    • Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
      Monika Julia Wolf, Alexandra Hoos, Judith Bauer, Steffen Boettcher, Markus Knust, Achim Weber, Nicole Simonavicius, Christoph Schneider, Matthias Lang, Michael Stürzl, Roland S. Croner, Andreas Konrad, Markus Manz, Holger Moch, Adriano Aguzzi, Geert van Loo, Manolis Pasparakis, Marco Prinz, Lubor Borsig and Mathias Heikenwalder.
      Cancer Cell 2012, Jul 10;22(1):91-105

    • Follicular dendritic cells emerge from ubiquitous perivascular precursors
      Nike Julia Krautler, Veronika Kana, Jan Kranich, Yinghua Tian, Dushan Perera, Doreen Lemm, Petra Schwarz, Annika Armulik, Jeffrey L. Browning, Michelle Tallquist, Thorsten Buch, José B. Oliveira-Martins, Caihong Zhu, Mario Hermann, Ulrich Wagner, Robert Brink, Mathias Heikenwalder, Adriano Aguzzi.
      Cell 2012, Jul 6; 150(1):194-206

    • „Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.“
      Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L.
      Nature. 2011 Nov 9. doi: 10.1038/nature10599. [Epub ahead of print]

    • Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by
      producing nitric oxide

      Stefanie Sieger, Hsin-Ying Huang, Chen-Ying Yang, Leonardo Scarpellino, Lucie Carrie, Sarah Essex, Peter J. Nelson, Mathias Heikenwalder, Hans Acha-Orbea, Christopher D.Buckley, Benjamin J. Marsland, Dietmar Zehn, Sanjiv A. Luther
      PLoS One, 11, 2011 Nov 9; 479(7374):547-51

    • Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.
      Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP.
      Gut. 2011 Sep 19. [Epub ahead of print]

    • Aerosols transmit prions to immunocompetent and immunodeficient mice            
      Mathias Heikenwalder *, Johannes Haybaeck *, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J. Fuchs, Lothar Stitz and Adriano Aguzzi.
      PLOS Pathog. 7(1): e1001257. doi:10.1371/journal.ppat.1001257

    • Peripherally Applied Ab-Containing Inoculates Induce Cerebral b-Amyloidosis.
      Eisele, Y., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S., Wolburg, H., Walker L., Staufenbiel, M., Heikenwalder, M., Jucker, M
      Science. 2010 Oct 21. [Epub ahead of print]

    • Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma?
      Vucur, M., Roderburg, C., Bettermann, K., Tacke, F., Heikenwalder, M., Trautwein, C. and Luedde, T.
      Oncotarget. 2010 Sep; 1(5):373-8. .

    • The unexpected role of lymphotoxin signaling in carcinogenesis: From lymphoid neogenesis to liver and prostate cancer development
      Wolf M, Seleznik G, Zeller N and Heikenwalder M.
      Oncogene
      . 2010 Jul 5 [Epub ahead of print]

    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immuneresponses
      Hapfelmeier S, Lawson M, Slack E, Kirundi J, Stoel M, Heikenwalder M, Cahenzli J, Velykoredko Y, Balmer M, Endt K, Geuking M, Curtiss 3rd R, McCoy K, and Macpherson A.
      Science. 2010 Jun 25;328(5986):1705-9

    • TAK1 suppresses a NEMO-dependent, but NF-kB independent pathway to liver cancer.
      Bettermann K, Vucur M, Koppe C, Heymann F, Haybaeck J, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, Akira S, Tacke F, Heikenwalder M, Trautwein C, and Luedde T.
      Cancer CELL. 2010 May 18;17(5):481-96

    • Hepatocyte-specific deletion of Mcl-1 triggers proliferation and hepatocarcinogenesis in mice.
      Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer P, Opferman J, Galle P, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H.
      Hepatology. 2009 Nov 30; DOI: 10.1002/hep.23479.

    • A lymphotoxin-driven pathway to chronic hepatitis induced liver cancer.
      Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Rolf Graf, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A and Heikenwalder M.
      Cancer CELL. 2009 Oct 6;16(4):295-308.

    • Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.
      Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A.
      Immunity. 2008 Dec 19;29(6):998-1008.

    • Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.
      Heikenwalder M,* Baenziger S,* Johansen P, Schlaepfer E, Hofer U, Miller RC, Diemand S, Honda K, Kundig TM, Aguzzi A, Speck RF.
      Blood. 2009 Jan 8;113(2):377-88.

    • Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
      Heikenwalder M,* Prinz M,* Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rülicke T, Macpherson AJ, Holländer GA, Nedospasov SA, Aguzzi A.
      Am J Pathol. 2008 Jun;172(6):1555-70.

    • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.
      Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, Brück W, Priller J, Prinz M.
      Nature Neuroscience 2007 Dec;10(12):1544-53.

    • Insights into prion strains and neurotoxicity.
      Aguzzi A, Heikenwalder M, Polymenidou M.
      Nature Reviews in Molecular and Cellular Biology. 2007 Jul;8(7):552-61.

    • Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-g C-/- mice.
      Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF.
      PNAS. 2006 Oct 24;103(43):15951-6. Epub 2006 Oct 12.

    • Pathogenesis of prion diseases: current status and future outlook.
      Aguzzi A, Heikenwalder M.
      Nature Reviews in Microbiology. 2006 Oct;4(10):765-75.

    • Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
      Lang KS, Georgiev P, Recher M, Navarini AA, Bergthaler A, Heikenwalder M, Harris NL, Junt T, Odermatt B, Clavien PA, Pircher H, Akira S, Hengartner H, Zinkernagel RM.
      J Clin Invest. 2006 Sep;116(9):2456-63.

    • Coincident scrapie infection and nephritis lead to urinary prion excretion.
      Heikenwalder M,* Seeger H,* Zeller N,* Kranich J, Schwarz P, Gaspert A, Seifert B, Miele G, Aguzzi A.
      Science. 2005 Oct 14;310(5746):324-6.

    • Prions, cytokines, and chemokines: a meeting in lymphoid organs.
      Aguzzi A, Heikenwalder M.
      Immunity. 2005 Feb;22(2):145-54.

    • Chronic lymphocytic inflammation specifies the organ tropism of prions.
      Heikenwalder M, Zeller N, Seeger H, Prinz M, Klöhn PC, Schwarz P, Ruddle N, Weissmann C, Aguzzi A.
      Science. 2005 Feb 18;307(5712):1107-10.

    • Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.
      Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A.
      Nature Medicine 2004 Feb;10(2):187-92.

    • Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
      Heikenwalder M,* Prinz M,* Junt T, Schwarz P, Glatzel M, Heppner FL, Fu YX, Lipp M, Aguzzi A.
      Nature. 2003 Oct 30;425(6961):957-62.

    • Prion diseases: Cannibals and garbage piles.
      Aguzzi A, Heikenwalder M.
      Nature. 2003 May 8;423(6936):127-9.

      * contributed equally.

    Patents

    Blockers of Light, LTa1b2 and LTa2b1 or its receptor LTbR for the prevention and treatment of chronic hepatitis and hepatocellular carcinoma". Patent-application Heikenwälder, Aguzzi und Universität Zürich, 10-2008; accepted 04-2010.