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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the nstitute for Pancreatic Islet Researcht (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
Recent Publications
Ashton MP, Eugster A, Dietz S, Loebel D, Lindner A, Kuehn D, Taranko AE, Heschel B, Gavrisan A, Ziegler AG, Aringer M, Bonifacio E. Single-cell profiling reveals dendritic cell signatures associated with autoimmune inflammation. Arthritis Rheumatol. 2018 Dec 4. doi: 10.1002/art.40793. [Epub ahead of print]
Weigert M, Schmidt U, Boothe T, Müller A, Dibrov A, Jain A, Wilhelm B, Schmidt D, Broaddus C, Culley S, Rocha-Martins M, Segovia-Miranda F, Norden C, Henriques R, Zerial M, Solimena M, Rink J, Tomancak P, Royer L, Jug F, Myers EW. Content-aware image restoration: pushing the limits of fluorescence microscopy. Nat Methods. 2018 Nov 26. doi: 10.1038/s41592-018-0216-7. [Epub ahead of print]
Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P, Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R. Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain. J Pineal Res. 2018 Nov 26:e12540. doi: 10.1111/jpi.12540. [Epub ahead of print]
Singh SP, Janjuha S, Chaudhuri S, Reinhardt S, Kränkel A, Dietz S, Eugster A, Bilgin H, Korkmaz S, Zararsız G, Ninov N, Reid JE. Machine learning based classification of cells into chronological stages using single-cell transcriptomics. Sci Rep. 2018 Nov 21;8(1):17156. doi: 10.1038/s41598-018-35218-5.
Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 2018 Nov 19. doi: 10.1038/s41590-018-0249-1. [Epub ahead of print]
Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck A. Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency. J Allergy Clin Immunol. 2018 Oct 16. pii: S0091-6749(18)31443-X. doi: 10.1016/j.jaci.2018.08.052. [Epub ahead of print]
- Endesfelder D, Castell WZ, Bonifacio E, Rewers M, Hagopian WA, She JX,Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP,Ziegler AG, Achenbach P; TEDDY Study Group. Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes.2018 Oct 10. pii: db180594. doi: 10.2337/db18-0594. [Epub ahead of print]
- von Loeffelholz C, Thomas-Rüddel D, Bauer M, Birkenfeld A. Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial. J Intensive Care Med. 2018 Oct 7:885066618803866. doi: 10.1177/0885066618803866. [Epub ahead of print]
- Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H. Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. J Am Coll Cardiol. 2018 Oct 9;72(15):1829-1844. doi: 10.1016/j.jacc.2018.07.081. Review.
- Brankatschk M, Gutmann T, Knittelfelder O, Palladini A, Prince E, Grzybek M, Brankatschk B, Shevchenko A, Coskun Ü, Eaton S. A Temperature-Dependent Switch in Feeding Preference Improves Drosophila Development and Survival in the Cold. Dev Cell. 2018 Sep 24;46(6):781-793.e4. doi: 10.1016/j.devcel.2018.05.028.
