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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the nstitute for Pancreatic Islet Researcht (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
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Recent Publications
Here you can find the 10 latest publications of our institute. If you are looking for older publications, please follow the link below to our publications.
- Kahl S, Gancheva S, Straßburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M.
Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial.
Diabetes Care. 2020 Feb;43(2):298-305. doi: 10.2337/dc19-0641. Epub 2019 Sep 20. PubMed PMID: 31540903. - Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A.
Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes.
FASEB J. 2020 Jan 9. doi: 10.1096/fj.201900125RR. [Epub ahead of print] PubMed PMID: 31916652. - Gutmann T, Schäfer IB, Poojari C, Brankatschk B, Vattulainen I, Strauss M, Coskun Ü.
Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain.
J Cell Biol. 2020 Jan 6;219(1). pii: e201907210. doi:10.1083/jcb.201907210. PubMed PMID: 31727777. - Knoop J, Eugster A, Gavrisan A, Lickert R, Sedlmeier EM, Dietz S, Lindner A, Warncke K, Hummel N, Ziegler AG, Bonifacio E.
Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4(+) T Cells in Offspring.
Diabetes. 2020 Jan 2. pii:db190751. doi: 10.2337/db19-0751. [Epub ahead of print] PubMed PMID: 31896551. - Mziaut H, Henniger G, Ganss K, Hempel S, Wolk S, McChord J, Chowdhury K, Ravassard P, Knoch KP, Krautz C, Weitz J, Grützmann R, Pilarsky C, Solimena M, Kersting S.
MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling.
Mol Metab. 2020 Jan;31:150-162. doi:10.1016/j.molmet.2019.11.012. Epub 2019 Nov 22. PubMed PMID: 31918917; PubMed Central PMCID: PMC6928290. - Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL.
Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.
Pharmacol Rev. 2020 Jan;72(1):343-379. doi:10.1124/pr.118.015735. Review. PubMed PMID: 31882442. - Bonifacio E, Achenbach P.
Birth and coming of age of islet autoantibodies.
Clin Exp Immunol. 2019 Dec;198(3):294-305. doi: 10.1111/cei.13360. Epub 2019 Sep 12. Review. PubMed PMID: 31397889; PubMed Central PMCID: PMC6857083. - Goldman O, Puchinsky D, Durlacher K, Sancho R, Ludwig B, Kugelmeier P, Heller C, Kunicher N, Bornstein SR, Treves AJ.
Lung Based Engineered Micro-Pancreas Sustains Human Beta Cell Survival and Functionality.
Horm Metab Res. 2019 Dec;51(12):805-811. doi: 10.1055/a-1041-3305. Epub 2019 Dec 11. PubMed PMID: 31826275. - Angelini G, Gissey LC, Del Corpo G, Giordano C, Cerbelli B, Severino A, Manco M, Basso N, Birkenfeld AL, Bornstein SR, Genco A, Mingrone G, Casella G.
New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
Sci Rep. 2019 Nov 21;9(1):17315. doi: 10.1038/s41598-019-53702-4. PubMed PMID: 31754142; PubMed Central PMCID: PMC6872729. - Fuchs YF, Sharma V, Eugster A, Kraus G, Morgenstern R, Dahl A, Reinhardt S, Petzold A, Lindner A, Löbel D, Bonifacio E.
Gene Expression-Based Identification of Antigen-Responsive CD8(+) T Cells on a Single-Cell Level.
Front Immunol. 2019 Nov 6;10:2568. doi: 10.3389/fimmu.2019.02568. eCollection 2019. PubMed PMID: 31781096; PubMed Central PMCID: PMC6851025.
- Kahl S, Gancheva S, Straßburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M.
