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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the nstitute for Pancreatic Islet Researcht (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
News
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29.05.2019 16 runners of the Paul Langerhans Institut Dresden joined 25,000 other runners on the 5km course...
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28.03.2019 Trend-setting for future therapy of T2D: International consortium with Dresdner participation...
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11.03.2019 New shotgun lipidomics method for molecular profiling of adipose tissue
Recent Publications
Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes. Eugster A, Kraus G, Lidzba V, Müller D, Jolink M, Ziegler AG, Bonifacio E. Diabetologia. 2019 Feb 21. doi: 10.1007/s00125-019-4832-2. [Epub ahead of print]
Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics. Grzybek M, Palladini A, Alexaki VI, Surma MA, Simons K, Chavakis T, Klose C, Coskun Ü. Mol Metab. 2019 Jan 30. pii: S2212-8778(18)31114-1. doi: 10.1016/j.molmet.2019.01.009. [Epub ahead of print]
Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, Bickle M, Gavalas A. Stem Cells. 2019 Jan 25. doi: 10.1002/stem.2979. [Epub ahead of print]
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families. Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group. Diabetes. 2019 Jan 17. pii: db180882. doi: 10.2337/db18-0882. [Epub ahead of print]
DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. Nat Immunol. 2018 Nov 19. doi: 10.1038/s41590-018-0249-1. [Epub ahead of print]
Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity? Penkov S, Mitroulis I, Hajishengallis G, Chavakis T. Trends Immunol. 2019 Jan;40(1):1-11. doi: 10.1016/j.it.2018.11.002. Epub 2018 Nov 29. Review.
- Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Delgadillo-Silva LF, Tsakmaki A, Akhtar N, Franklin ZJ, Konantz J, Bewick GA, Ninov N. Dis Model Mech. 2019 Jan 23;12(1). pii: dmm036004. doi: 10.1242/dmm.036004.
- Reprint of: Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H. J Am Coll Cardiol. 2018 Dec 11;72(23 Pt B):3071-3086. doi: 10.1016/j.jacc.2018.10.026. Review.
