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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the nstitute for Pancreatic Islet Researcht (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
Recent Publications
Simultaneous lineage tracing and cell type identification using CRISPR/Cas9 induced genetic scars. Spanjaard B et al. Nature Biotechnology 2018, doi: 10.1038/nbt.4124
Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. Janjuha S et al. Elife. 2018 Apr 6;7. pii: e32965. doi: 10.7554/eLife.32965.
Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor. Gutmann T, Kim KH, et al. J Cell Biol. 2018 Feb 16. doi: 10.1083/jcb.201711047.
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Solimena et al., Diabetologia, 2017 Nov 28, doi: 10.1007/s00125-017-4500-3.
Monitoring Membrane Lipidome Turnover by Metabolic 15N Labeling and Shotgun Ultra-High-Resolution Orbitrap Fourier Transform Mass Spectrometry, Schuhmann et al., Anal. Chem.,2017, DOI: 10.1021/acs.analchem.7b03437
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes., Ludwig et al., PNAS, Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1708420114
Is mIndy a mediator of energy metabolism reprogramming in hepatocellular carcinoma induced by IL-6/STAT3 signaling? von Loeffelholz C, Birkenfeld AL. Hepatology. 2017 Oct 12. doi: 10.1002/hep.29591.
Intra-individual variability and circadian rhythm of vascular endothelial growth factors in subjects with normal glucose tolerance and type 2 diabetes. Hanefeld et al., PLoS One. 2017 Oct 9;12(10):e0184234. doi: 10.1371/journal.pone.0184234. eCollection 2017.
The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target. Willmes et al., Pharmacol Ther. 2017 Oct 4. pii: S0163-7258(17)30240-1. doi: 10.1016/j.pharmthera.2017.10.<wbr />003.
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Singh et al., Nat Commun. 2017 Sep 22;8(1):664. doi: 10.1038/s41467-017-00461-3.
A 4D view on insulin secretory granule turnover in the β-cell. Müller et al., Diabetes Obes Metab. 2017 Sep;19 Suppl 1:107-114. doi: 10.1111/dom.13015.
Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Chen et al.., Mol Metab. 2017 Jul 8;6(9):943-957. doi: 10.1016/j.molmet.2017.06.019.
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. Serafimidis et al., PLoS Biol. 2017 Mar 1;15(3):e2000949. doi: 10.1371/journal.pbio.2000949. eCollection 2017.
Calcium directly regulates phosphatidylinositol 4,5-bisphosphate headgroup conformation and recognition. Bilkova et al., J Am Chem Soc. 2017 Feb 8. doi: 10.1021/jacs.6b11760. [Epub ahead of print]
The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. von Loeffelholz et al., Hepatology. 2017 Jan 30. doi: 10.1002/hep.29089. [Epub ahead of print]
Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation Cohrs et al., Endocrinology (2017) en.2016-1184. DOI: doi.org/10.1210/en.2016-1184 Published: 27 January 2017
A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags. Müller et al., Sci Rep. 2017 Dec;7(1):23. doi: 10.1038/s41598-017-00033-x. Epub 2017 Feb 2.
