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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the Institute for Pancreatic Islet Research (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
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Recent Publications
Here you can find the 10 latest publications of our institute. If you are looking for older publications, please follow the link below to our publications.
- Schumann et al. Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol. 2021 Jul 1;4(1):826. doi: 10.1038/s42003-021-02279-8.
- Janke et al. Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments. Membranes (Basel). 2021 Jun 30;11(7):499. doi: 10.3390/membranes11070499.
- Wigger et al. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nat Metab. 2021 Jun 28. doi: 10.1038/s42255-021-00420-9.
- Bornstein et al. Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? Mol Psychiatry. 2021 Jun 17:1-4. doi: 10.1038/s41380-021-01148-4.
- Sormendi et al. HIF2α is a direct regulator of neutrophil motility. Blood. 2021 Jun 17;137(24):3416-3427. doi: 10.1182/blood.2020007505.
- Steenblock et al. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021 Jun 10;12(1):3534. doi: 10.1038/s41467-021-23886-3.
- Chen et al., The trans-ancestral genomic architecture of glycemic traits. Nat Genet. 2021 May 31. doi: 10.1038/s41588-021-00852-9.
- Breunig et al., Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells. Cell Stem Cell. 2021 Apr 15:S1934-5909(21)00111-9. doi: 10.1016/j.stem.2021.03.005.
- Lechner et al., Waist-to-height ratio and metabolic phenotype compared to the Matsuda index for the prediction of insulin resistance. Sci Rep. 2021 Apr 15;11(1):8224. doi: 10.1038/s41598-021-87266-z.
- Huber et al., Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices. J Vis Exp. 2021 Apr 12;(170). doi: 10.3791/62207.
