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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the nstitute for Pancreatic Islet Researcht (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
Recent Publications
TRThe Expression of Aldolase B in Islets is Negatively Associated with Insulin Secretion in Humans. Gerst F et al. J Clin Endocrinol Metab. 2018 Sep 7. doi: 10.1210/jc.2018-00791.
Myocardial metabolism in heart failure: Purinergic signalling and other metabolic concepts Birkenfeld AL et al. Pharmacol Ther. 2018 Aug 25. pii: S0163-7258(18)30153-0. doi: 10.1016/j.pharmthera.2018.08.015. Review.
Innate immune cells in the adipose tissue. Chung KJ et al. Rev Endocr Metab Disord. 2018 Jun 19. doi: 10.1007/s11154-018-9451-6. Review.
Simultaneous lineage tracing and cell type identification using CRISPR/Cas9 induced genetic scars. Spanjaard B et al. Nature Biotechnology 2018, doi: 10.1038/nbt.4124
Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. Janjuha S et al. Elife. 2018 Apr 6;7. pii: e32965. doi: 10.7554/eLife.32965.
Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor. Gutmann T, Kim KH, et al. J Cell Biol. 2018 Feb 16. doi: 10.1083/jcb.201711047.
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Solimena et al., Diabetologia, 2017 Nov 28, doi: 10.1007/s00125-017-4500-3.
Monitoring Membrane Lipidome Turnover by Metabolic 15N Labeling and Shotgun Ultra-High-Resolution Orbitrap Fourier Transform Mass Spectrometry, Schuhmann et al., Anal. Chem.,2017, DOI: 10.1021/acs.analchem.7b03437
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes., Ludwig et al., PNAS, Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1708420114
Is mIndy a mediator of energy metabolism reprogramming in hepatocellular carcinoma induced by IL-6/STAT3 signaling? von Loeffelholz C, Birkenfeld AL. Hepatology. 2017 Oct 12. doi: 10.1002/hep.29591.
