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Impairment and/or loss of pancreatic islet beta cells are at the origin of all forms of diabetes, leading to increased blood glucose levels. Scientists of the nstitute for Pancreatic Islet Researcht (IPI/PLID) are working to decipher the causal mechanisms for these deficiencies with the aim of developing new approaches to protect or restore beta cell function and viability.
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Recent Publications
Here you can find the 10 latest publications of our institute. If you are looking for older publications, please follow the link below to our publications.
- Kahl S, Gancheva S, Straßburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M. Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial. Diabetes Care. 2019 Sep 20. pii: dc190641. doi: 10.2337/dc19-0641. [Epub ahead of print] PubMed PMID: 31540903.
- Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov D, Willmes DM, Wurmsee S, Geisberger S, Dechend R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena M, Muller DN, Birkenfeld AL. Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells. Proc Natl Acad Sci U S A. 2019 Sep 16. pii: 201903678. doi: 10.1073/pnas.1903678116. [Epub ahead of print] PubMed PMID: 31527264.
- Barovic M, Distler M, Schöniger E, Radisch N, Aust D, Weitz J, Ibberson M, Schulte AM, Solimena M. Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes. Mol Metab. 2019 Sep;27S:S1-S6. doi: 10.1016/j.molmet.2019.06.006. Review. PubMed PMID: 31500820.
- Timpel P, Harst L, Reifegerste D, Weihrauch-Blüher S, Schwarz PEH. What should governments be doing to prevent diabetes throughout the life course? Diabetologia. 2019 Oct;62(10):1842-1853. doi: 10.1007/s00125-019-4941-y. Epub
2019 Aug 27. Review. PubMed PMID: 31451873. - El-Agroudy NN, Kurzbach A, Rodionov RN, O'Sullivan J, Roden M, Birkenfeld AL, Pesta DH. Are Lifestyle Therapies Effective for NAFLD Treatment? Trends Endocrinol Metab. 2019 Aug 15. pii: S1043-2760(19)30136-5. doi:
10.1016/j.tem.2019.07.013. [Epub ahead of print] Review. PubMed PMID: 31422872. - Straube R, Voit-Bak K, Gor A, Steinmeier T, Chrousos GP, Boehm BO, Birkenfeld AL, Barbir M, Balanzew W, Bornstein SR. Correction: Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis? Horm Metab Res. 2019 Aug;51(8):554. doi: 10.1055/a-0976-7010. Epub 2019 Aug 13. PubMed PMID: 31408899.
- Bonifacio E, Achenbach P. Birth and coming of age of islet autoantibodies. Clin Exp Immunol. 2019 Aug 9. doi: 10.1111/cei.13360. [Epub ahead of print] Review. PubMed PMID: 31397889.
- Hoffmann VS, Weiß A, Winkler C, Knopff A, Jolink M, Bonifacio E, Ziegler AG. Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence. BMC Med. 2019 Jul 9;17(1):125. doi: 10.1186/s12916-019-1360-3. PubMed PMID: 31286933; PubMed Central PMCID: PMC6615150.
- Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E.
Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus. Mol Metab. 2019 Aug;26:30-44. doi: 10.1016/j.molmet.2019.05.011. Epub 2019 Jun 4. PubMed PMID: 31221621; PubMed Central PMCID: PMC6667734. - Jendle J, Birkenfeld AL, Polonsky WH, Silver R, Uusinarkaus K, Hansen T, Håkan-Bloch J, Tadayon S, Davies MJ. Improved treatment satisfaction in patients with type 2 diabetes treated with once-weekly semaglutide in the SUSTAIN trials. Diabetes Obes Metab. 2019 Oct;21(10):2315-2326. doi: 10.1111/dom.13816. Epub 2019 Jul 12. PubMed PMID: 31215727.
