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Invisible and Ultrafine – How Do Air Pollutants Impact Health?

Air pollutants can not only influence the development and progression of lung diseases but also trigger inflammation throughout the body. Researchers at Helmholtz Munich are investigating the connections between invisible harmful particles in the air and cardiovascular diseases, diabetes, lung diseases, and allergies to understand disease mechanisms, provide expert guidance in setting preventive limits, and develop innovative therapies.

Air pollutants can not only influence the development and progression of lung diseases but also trigger inflammation throughout the body. Researchers at Helmholtz Munich are investigating the connections between invisible harmful particles in the air and cardiovascular diseases, diabetes, lung diseases, and allergies to understand disease mechanisms, provide expert guidance in setting preventive limits, and develop innovative therapies.

The Environment Influences Our Health

A common question asked by journalists and politicians when defining new limits is, "How are diseases and air pollutants related?" Prof. Claudia Traidl-Hoffmann answers with a clear message: "Only on a healthy Earth are there healthy people."

Air pollutants are an important piece of the mosaic in the complex interplay between climate and health.
Prof. Claudia Traidl-Hoffmann

The environmental physician and Director of the Institute of Environmental Medicine at Helmholtz Munich stresses the importance of understanding the impact of environmental factors on health. Initially specializing in dermatology and studying allergy development, she realized the need to incorporate environmental factors after closely examining her patients. It is now clear that pollutants can pave the way for allergies. As a chief physician at the University Hospital in Augsburg, she notices the effects of climate change on people, even under the moderate conditions of Central Europe. Patients suffering from hay fever in January and tick bites, or an increase in psychiatric symptoms and strokes during certain weather conditions, all point to the significant role of air pollutants. Traidl-Hoffmann states, "Air pollutants are an essential part in this large puzzle. The combustion processes responsible for air pollutants also fuel climate change. Air pollutants and climate change, in turn, significantly threaten our health."

 If someone is continuously exposed to pollutants as a child of five and then develops diabetes much later at the age of 50, the question is: How are these two things related, what has happened in the body over all those years?
Prof. Claudia Traidl-Hoffmann

"In recent years, we have gained a better understanding of the effects of air pollutants on human health," says environmental physician Claudia Traidl-Hoffmann of Helmholtz Munich. However, new questions continue to arise for her and her colleagues. Traidl-Hoffmann views the interplay of space and time with air pollutants as the holy grail of research. She questions, "If a five-year-old child is continuously exposed to pollutants and develops diabetes at the age of 50, the question is, how are these two things connected, and what has happened in the body over all those years?"

Air Pollutants Make People Sick

Many high-caliber researchers at Helmholtz Munich focus on air quality. In recent years, the importance of the topic has become increasingly clear. The "Lancet Countdown on Health and Climate Change," an annual publication of the medical journal of the same name that assesses the effects of climate change, has definitively shown that air pollutants make people sick. It also demonstrates that reducing pollutants can have a positive impact.

Clean Air Is a Human Right

Ella's case made headlines worldwide. The nine-year-old girl from London died of asthma in 2013. She was healthy for the first seven years of her life but developed asthma, and shortly after her ninth birthday, died of a sudden asthma attack. She became the first person in the world for whom air pollution was recorded as the cause of death. The World Health Organization has since classified clean air as a human right.

Long-Term Studies as a Treasure Trove for Health Research

Prof. Annette Peters, who heads the Institute of Epidemiology at Helmholtz Munich is a leading expert on air pollutants and specializes in large, long-term population studies. In the NAKO Health Study, for example, where more than 200,000 participants are followed over many years, Peters played a pivotal role during the COVID-19 pandemic. One of the questions in such studies is, of course, "Who gets sick due to air pollutants?" Participants are interviewed and examined, and their place of residence is considered to  analyze the level of air pollutant exposure. This allows the study of their influence on human health over many years.

Fine Particles Trigger Inflammation

The evidence is clear: Fine dust, for example, penetrates deep into the lungs and triggers inflammation reactions there. The consequences extend beyond the lungs, affecting the cardiovascular system, potentially causing heart attacks, favoring dementia, and even affecting the unborn life of pregnant women. "Emissions from combustion processes, whether from vehicle engines, power plants, or heating, are particularly harmful," says Peters. The fine dust emitted contains numerous particles with hazardous properties, such as soot. Epidemiological studies have conclusively shown that fine dust composed of particles with diameters less than 2.5 µm harms health. Smaller particles in the air, known as ultrafine particles (UFP), contribute to health effects, but the evidence for regulatory action remains uncertain.

 

Expert Knowledge: Ultrafine Particles

Ultrafine Particles (UFP) are very small particles with a diameter smaller than 0.1 µm or 100 nm in the air. 



These tiny particles constitute a small portion of fine dust mass but dominate in terms of number and particle surface area, making them significant from a toxicological perspective. Annette Peters and her team therefore examine ultrafine dust in their studies. Their initial findings indicate a significantly increased risk of death due to respiratory diseases five to seven days after exposure to ultrafine particles. Another study revealed more hospital admissions for cardiovascular and respiratory diseases during periods of high fine dust concentrations from 2017 to 2020.

It became clear that the mixture of particles and gases in the air is complex, and the effects of particles of different sizes need to be differentiated in future risk assessments.
Prof. Annette Peters

 

Targeting the Smallest Particles

"The studies confirm the impact of air pollutants on health, and it became clear that the mixture of particles and gases in the air is complex, and the effects of particles of different sizes need to be differentiated in future risk assessments. Therefore, in 2021, the World Health Organization called for not only reducing limits for known air pollutants but also for obtaining more high-quality data on ultrafine particles or incorporating ultrafine particles into existing routine measurements, forming a crucial basis for the investigation of health effects."

Helmholtz Munich Contributes to Better Health

Annette Peters, who was involved as a consulting expert in the decision-making process in 2021, recalls, "The newer scientific studies were taken very seriously by the WHO during the decision-making process. Very low fine dust concentrations were set. The limit for nitrogen dioxide was significantly reduced from 40 micrograms per cubic meter to only 10 micrograms. Another positive aspect is that peak concentration values were also reduced – previously, the guidelines for peak times were set independently of the annual average values." In plain language, this means that governments should now establish significantly lower limits for air pollutant emissions, and even though WHO guidelines are only recommendations, they emphasize the urgency to lawmakers. "This is particularly true for the European Union's limits. From a scientific perspective, the European Commission's current proposals are not ambitious enough and do not effectively protect public health, especially for children and patients with lung, cardiovascular diseases, or diabetes," says the epidemiologist. 

Fine Particles Know No Borders

Regarding air quality, we must think and collaborate on a global scale.
Prof. Annette Peters

One particularly positive aspect highlighted by experts is that these guidelines apply worldwide. Air pollution can be measured at the source of emissions, but it is not confined to the local environment, as particles can be transported by the wind over thousands of kilometers. "In Europe, we are fortunate to mainly receive air from the west, with the Atlantic Ocean in that direction. However, during east winds, we can see that pollutants from entirely different regions are transported to us," says Annette Peters, pointing out the Sahara dust that reaches Germany on hot summer days. Peters' conclusion is clear: "Regarding air quality, we must think and collaborate on a global scale. Therefore, we need an update of limits in Europe to effectively protect public health and the environment."

One Health – Climate Change and Heat Trigger Common Diseases

In academic circles, an approach known as "One Health" or "Planetary Health" is gaining importance. It recognizes the interdependence of human health, healthy animals, and a healthy planet. Doctors in their clinics frequently observe how closely these interactions are linked: People with asthma, for example, experience breathing difficulties and respiratory problems when exposed to increased nitrogen dioxide levels. Symptoms worsen if patients are simultaneously exposed to allergens, such as pollen in the spring or dust mites in the winter. The effects of heat waves are much more significant when air pollutant levels are high as well. These findings were revealed in large-scale, Europe-wide studies on climate change conducted by Helmholtz Munich.

As a researcher in this field, I feel obligated to present these connections objectively and advise decision-makers to contribute to long-term better health.
Prof. Annette Peters

 "An important question for the future is how climate change and the efforts to become carbon neutral by 2045 will affect the composition of air pollutants and their interactions with weather extremes, such as heatwaves," says Annette Peters. From her perspective, there are important synergies, and the ongoing transformations in society, the economy, and urban planning offer hope that health effects observed today will diminish in relevance over the next few decades. "As a researcher in this field, I feel obligated to present these connections objectively and advise decision-makers to contribute to  preserving health over longer-terms. The interdisciplinary collaboration at Helmholtz Munich, with a wide range of expertise, enables recommendations that consider various factors, including genetics, epigenetics, and diseases such as diabetes, lung diseases, and allergies."

Check out more about research on air pollution and climate change on health at Helmholtz Munich

Find more information about One Health: Climate Change Triggers Common Diseases.

Read the press release on Climate Change and Human Health: Findings from the Lancet Countdown Report 2023.

Check out findings about Air Pollution and Herpes Virus: How Nanoparticles Promote Chronic Lung Diseases like COPD.

Learn what AI and Machine Learning Tell Us About the Link Between Environment and Human Health.

Learn about the NAKO Health Study.

Learn more about the scientists involved in the research field of air pollution and climate change

Prof. Annette Peters, Director of the Institute of Epidemiology at Helmholtz Munich.

Prof. Claudia Traidl-Hoffmann, Director of the Institute of Environmental Medicine at Helmholtz Munich.

Latest update: November 2023.